Mead Lab Publications

Read publications out of the Mead Lab at Case Western Reserve University.

Aggrecan Accumulates At Sites Of Increased Pulmonary Arterial Pressure In Idiopathic Pulmonary Arterial Hypertension

Oscar van der Have, Timothy J Mead, Christian Westöö, Niccolò Peruzzi, Ayse C Mutgan, Christian Norvik, Martin Bech, André Struglics, Konrad Hoetzenecker, Hans Brunnström, Gunilla Westergren-Thorsson, Grazyna Kwapiszewska, Suneel S Apte, Karin Tran-Lundmark | pmid:36824691

Pulmonary circulation | February 24, 2023

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Adamts6: Emerging Roles In Cardiovascular, Musculoskeletal And Cancer Biology

Timothy J Mead | pmid:36339722

Frontiers in molecular biosciences | November 7, 2022

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Proteolysis: A Key Post-Translational Modification Regulating Proteoglycans

Timothy J Mead, Sumit Bhutada, Daniel R Martin, Suneel S Apte | pmid:35785985

American journal of physiology. Cell physiology | July 5, 2022

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Proteolysis Of Fibrillin-2 Microfibrils Is Essential For Normal Skeletal Development

Timothy J Mead, Daniel R Martin, Lauren W Wang, Stuart A Cain, Cagri Gulec, Elisabeth Cahill, Joseph Mauch, Dieter Reinhardt, Cecilia Lo, Clair Baldock, Suneel S Apte | pmid:35503090

eLife | May 3, 2022

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Adamtsl5 Is An Epigenetically Activated Gene Underlying Tumorigenesis And Drug Resistance In Hepatocellular Carcinoma

Maria Arechederra, Sehrish K Bazai, Ahmed Abdouni, Celia Sequera, Timothy J Mead, Sylvie Richelme, Fabrice Daian, Stéphane Audebert, Rosanna Dono, Anthony Lozano, Damien Gregoire, Urszula Hibner, Daniela S Allende, Suneel S Apte, Flavio Maina | pmid:33197513

Journal of hepatology | November 16, 2020

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The Secreted Protease Adamts18 Links Hormone Action To Activation Of The Mammary Stem Cell Niche

Dalya Ataca, Patrick Aouad, Céline Constantin, Csaba Laszlo, Manfred Beleut, Marie Shamseddin, Renuga Devi Rajaram, Rachel Jeitziner, Timothy J Mead, Marian Caikovski, Philipp Bucher, Giovanna Ambrosini, Suneel S Apte, Cathrin Brisken | pmid:32218432

Nature communications | March 29, 2020

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Visualization and Quantification of Pericellular Matrix

Timothy J Mead, Suneel S Apte | pmid:31463918

Methods in molecular biology (Clifton, N.J.) | August 30, 2019

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Alizarin Red and Alcian Blue Preparations to Visualize the Skeleton

Timothy J Mead | pmid:31463914

Methods in molecular biology (Clifton, N.J.) | August 30, 2019

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Expression Analysis by RNAscope™ in Situ Hybridization

Timothy J Mead, Suneel S Apte | pmid:31463911

Methods in molecular biology (Clifton, N.J.) | August 30, 2019

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Adamts10 Inactivation in Mice Leads to Persistence of Ocular Microfibrils Subsequent to Reduced Fibrillin-2 Cleavage

Lauren W Wang, Wendy E Kutz, Timothy J Mead, Lauren C Beene, Shweta Singh, Michael W Jenkins, Dieter P Reinhardt, Suneel S Apte | pmid:30201140

Matrix biology : journal of the International Society for Matrix Biology | September 12, 2018

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Exome-Chip Meta-analysis Identifies Novel Loci Associated with Cardiac Conduction, Including ADAMTS6

Bram P Prins, Timothy J Mead, Jennifer A Brody, Gardar Sveinbjornsson, Ioanna Ntalla, Nathan A Bihlmeyer, Marten van den Berg, Jette Bork-Jensen, Stefania Cappellani, Stefan Van Duijvenboden, Nikolai T Klena, George C Gabriel, Xiaoqin Liu, Cagri Gulec, Niels Grarup, Jeffrey Haessler, Leanne M Hall, Annamaria Iorio, Aaron Isaacs, Ruifang Li-Gao, Honghuang Lin, Ching-Ti Liu, Leo-Pekka Lyytikäinen, Jonathan Marten, Hao Mei, Martina Müller-Nurasyid, Michele Orini, Sandosh Padmanabhan, Farid Radmanesh, Julia Ramirez, Antonietta Robino, Molly Schwartz, Jessica van Setten, Albert V Smith, Niek Verweij, Helen R Warren, Stefan Weiss, Alvaro Alonso, David O Arnar, Michiel L Bots, Rudolf A de Boer, Anna F Dominiczak, Mark Eijgelsheim, Patrick T Ellinor, Xiuqing Guo, Stephan B Felix, Tamara B Harris, Caroline Hayward, Susan R Heckbert, Paul L Huang, J W Jukema, Mika Kähönen, Jan A Kors, Pier D Lambiase, Lenore J Launer, Man Li, Allan Linneberg, Christopher P Nelson, Oluf Pedersen, Marco Perez, Annette Peters, Ozren Polasek, Bruce M Psaty, Olli T Raitakari, Kenneth M Rice, Jerome I Rotter, Moritz F Sinner, Elsayed Z Soliman, Tim D Spector, Konstantin Strauch, Unnur Thorsteinsdottir, Andrew Tinker, Stella Trompet, André Uitterlinden, Ilonca Vaartjes, Peter van der Meer, Uwe Völker, Henry Völzke, Melanie Waldenberger, James G Wilson, Zhijun Xie, Folkert W Asselbergs, Marcus Dörr, Cornelia M van Duijn, Paolo Gasparini, Daniel F Gudbjartsson, Vilmundur Gudnason, Torben Hansen, Stefan Kääb, Jørgen K Kanters, Charles Kooperberg, Terho Lehtimäki, Henry J Lin, Steven A Lubitz, Dennis O Mook-Kanamori, Francesco J Conti, Christopher H Newton-Cheh, Jonathan Rosand, Igor Rudan, Nilesh J Samani, Gianfranco Sinagra, Blair H Smith, Hilma Holm, Bruno H Stricker, Sheila Ulivi, Nona Sotoodehnia, Suneel S Apte, Pim van der Harst, Kari Stefansson, Patricia B Munroe, Dan E Arking, Cecilia W Lo, Yalda Jamshidi | pmid:30012220

Genome biology | July 18, 2018

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ADAMTS Proteins in Human Disorders

Timothy J Mead, Suneel S Apte | pmid:29885460

Matrix biology : journal of the International Society for Matrix Biology | June 10, 2018

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ADAMTS9-Regulated Pericellular Matrix Dynamics Governs Focal Adhesion-Dependent Smooth Muscle Differentiation

Timothy J Mead, Yaoyao Du, Courtney M Nelson, Ndeye-Aicha Gueye, Judith Drazba, Carolyn M Dancevic, Mireille Vankemmelbeke, David J Buttle, Suneel S Apte | pmid:29642006

Cell reports | April 12, 2018

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The Metalloproteinase-Proteoglycans ADAMTS7 and ADAMTS12 Provide an Innate, Tendon-Specific Protective Mechanism Against Heterotopic Ossification

Timothy J Mead, Daniel R McCulloch, Jason C Ho, Yaoyao Du, Sheila M Adams, David E Birk, Suneel S Apte | pmid:29618652

JCI insight | April 6, 2018

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Massive Aggrecan and Versican Accumulation in Thoracic Aortic Aneurysm and Dissection

Frank S Cikach, Christopher D Koch, Timothy J Mead, Josephine Galatioto, Belinda B Willard, Kelly B Emerton, Matthew J Eagleton, Eugene H Blackstone, Francesco Ramirez, Eric E Roselli, Suneel S Apte | pmid:29515038

JCI insight | March 9, 2018

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