Publications
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/?term=Remy+KE&cauthor_id=32687484
News
Dr. Kenneth Remy Elected as the Chair of the Research Section for the Society of Critical Care Medicine
Kenneth E. Remy, MD, MHSc, MSCI, FCCM, The Ellery Sedgwick, Jr. Chair and Distinguished Scientist in Cardiovascular Research, Inaugural director of the Blood, Heart, Lung, and Immunology Research Center at Case Western Reserve University and University Hospitals of Cleveland, and faculty in the Departments of Internal Medicine and Pediatrics has been elected as the chair of the Research Section for the Society of Critical Care Medicine (SCCM).
The Society of Critical Care Medicine (SCCM) is the largest non-profit medical organization in the practice of critical care. SCCM was established in 1970 and is an independently incorporated international, educational, and scientific society based in the United States. Its members are multi-professional health professionals providing care to critically ill and injured patients, and SCCM is the only organization representing all critical care team's professional components. The Society supports research and education and advocates on issues related to critical care. The Society has over 35,000 members worldwide, and the research section has over 4,000 section members. A central component of the Society's mission is the support of quality-based improvement initiatives and the support of multi-professional research at all levels. The Research Section supports research development among Society members and promotes communication about opportunities and networks.
Dr. Remy also serves as UH Rainbow Babies & Children's first international expert for the Surviving Sepsis Campaign (SSC) of the International Surviving Sepsis Campaign. This campaign is a joint initiative of the SCCM and the European Society of Intensive Care Medicine (ESICM). The SSC is a team of multidisciplinary, international experts committed to improving the time to recognize and treat sepsis and septic shock.
Dr. Remy is an international expert in adult and pediatric sepsis, COVID-19 disease, and global health. As an adult and pediatric critical care physician, his research focuses on heme-based trafficking and signaling in immune dysregulation in the context of diseases of intravascular hemolysis (COVID, sepsis, malaria, sickle cell disease, thalassemia) and after red blood cell transfusion, and real-time immunophenotyping of pro and hypoinflammatory states to identify timing for immunoadjuvant therapies. In this new role as Chair, Dr. Remy endeavors to grow multidisciplinary research across methodologies (implementation science, data science, basic and translational science, bereavement and palliative care, simulation, and education research, global health research, and mixed methods work) to further expand the ability to learn new associations and develop causal pathways in critical illness.
International Critical Care Expert Selected for Prestigious Campaign to Lessen Impact of Sepsis Worldwide
Kenneth E. Remy, MD, MHSc, MSCI, FCCM, The Ellery Sedgwick, Jr. Chair and Distinguished Scientist in Cardiovascular Research, Inaugural director of the Blood, Heart, Lung, and Immunology Research Center at Case Western Reserve University and University Hospitals of Cleveland, and faculty in the Departments of Internal Medicine and Pediatrics was selected to serve as an international expert for the Surviving Sepsis Campaign (SSC). Sepsis and septic shock are leading causes of death worldwide, accounting for over 11 million lives lost.
The International Surviving Sepsis Campaign is a joint initiative of the Society of Critical Care Medicine (SCCM) and the European Society of Intensive Care Medicine (ESICM). These societies are committed to reducing mortality and morbidity from sepsis and septic shock worldwide. The multidisciplinary, international experts who lead the SCC are committed to improving the time to recognize and treat sepsis and septic shock. The campaign selects less than 60 world experts in sepsis, and thus the selection of Dr. Remy for this campaign is an institution’s first.
Collaborating with other experts, Dr. Remy will develop the 2024 pediatric sepsis guidelines and then, sequentially, the adult guidelines. The guidelines process will closely follow the first edition of the “Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children,” which provides guidance for the clinician caring for children with a sepsis or septic shock diagnosis in the PICU.
Dr. Remy’s expertise in immunology and research were guiding factors in his selection to lead a special panel for the SSC initiative. The approach of the SSC campaign includes building awareness of sepsis, improving diagnosis, increasing the use of appropriate treatment, educating healthcare professionals, improving post-intensive care unit care, developing guidelines for care, and facilitating data collection for audit and feedback in a reduction in sepsis mortality. The SCC campaign and guidelines are the background for all sepsis management in resource-rich and resource-limited countries.
Dr. Remy is a clinical provider in both the adult and pediatric critical care units at University Hospitals Cleveland Medical Center and UH Rainbow Babies & Children’s Hospital located in Cleveland’s University Circle. In addition to his interest in sepsis, Dr. Remy’s expertise and experience extends to COVID, global health, bioethics, humor therapy and palliative care.
Projects
Heme-Based Trafficking and Signaling
Researching the impact of heme on immune dysregulation in diseases associated with intravascular hemolysis such as COVID-19, sepsis, malaria, sickle cell disease, and thalassemia, as well as following red blood cell transfusions.
Real-Time Immunophenotyping
Developing techniques to identify pro-inflammatory and hypoinflammatory states in real time to optimize the timing for immunoadjuvant therapies.
COVID-19 Disease Progression
Studying the hematologic and immune responses to COVID-19, including the identification of an immunosuppressive phenotype characterized by T cell exhaustion in critically ill patients.
Host Immune Responses
Investigating the immune responses in various diseases including sepsis, acute respiratory distress syndrome (ARDS), sickle cell disease, and malaria.
Heme-Immune Interactions
Exploring the interactions between host immune responses and heme, particularly in the context of disease.
Disease Signaling Pathways
Focusing on the development of new methods to evaluate disease signaling pathways, creating bench-bedside phenotypes, and developing therapeutics.
Precision Medicine Therapies
Transitioning from bench research to bedside clinical applications to tailor precise therapeutic approaches to individual patient needs.
Clinical Research
Engaging in 'dry bench' work involving the analysis of hospital electronic medical records for studies on acute lung injury, pneumonia, sepsis, and other critical illnesses.
Join Us
Please email Dr. Remy at kenneth.remy@uhhospitals.org
Or Daniel Chen at dhc2@case.edu