Risk stratification using coronary artery calcium and potential benefit of semaglutide therapy: A cost-effectiveness modelling study. Ponnana SR, Zhang T, Sirasapalli SK, Chen Z, Dazard JE, Surya N, Elhussain S, Sivanantham K, Okyere R, Neeland IJ, Rajagopalan S, Deo SV. Diabetes Obes Metab. 2026 Feb 2. doi: 10.1111/dom.70515. Epub ahead of print. PMID: 41622983.
Wireless Movement Activity and Cardiometabolic Disease Risk in Historical Redlined Areas. Zhang T, Ponnana SR, Sirasapalli SK, Dazard JE, Sivanantham K, Deo SV, Chen Z, Rajagopalan S. JACC Adv. 2026 Jan 22;5(2):102528. doi: 10.1016/j.jacadv.2025.102528. Epub ahead of print. PMID: 41576599; PMCID: PMC12860994.
Social vulnerability and mortality attributable to non-optimal temperature in the United States: A county-level ecological analysis. Vieira de Oliveira Salerno PR, Estrada-Mendizabal RJ, Chen Z, Dazard JE, Nasir K, Requia W, Brook RD, Rajagopalan S, Al-Kindi S, Deo SV. Curr Probl Cardiol. 2026 Jan 11;51(4):103260. doi: 10.1016/j.cpcardiol.2026.103260. Epub ahead of print. PMID: 41529749.
The double helix meets dirty air: how genes and PM2.5 converge on coronary risk. Rajagopalan S, Chen Z, Dazard JE. Eur J Prev Cardiol. 2025 Dec 23;32(18):1891-1892. doi: 10.1093/eurjpc/zwaf331. PMID: 40570184.
Emerging AI tools for geospatially resolved cardiovascular risk. Chen Z, Dazard JE, Deo S, Al-Kindi S, Rajagopalan S. Nat Rev Cardiol. 2025 Oct;22(10):697-699. doi: 10.1038/s41569-025-01204-4. PMID: 40813468.
Air pollution modulates brown adipose tissue function through epigenetic regulation by HDAC9 and KDM2B. Palanivel R, Dazard JE, Park B, Costantino S, Moorthy ST, Vergara-Martel A, Cara EA, Edwards-Glenn J, Biswal S, Chen LC, Jain MK, Paneni F, Rajagopalan S. JCI Insight. 2025 Sep 23;10(18):e187023. doi: 10.1172/jci.insight.187023. PMID: 40985891; PMCID: PMC12548086.
AI-Enhanced Analysis of Built Environment Imagery and Neighborhood Obesity in US Cities. Chen Z, Zhang T, Dazard JE, Ponnana SR, Dong W, Moorthy S, Sirasapalli SK, Khraishah H, Deo S, Rajagopalan S, Al-Kindi S. JAMA Netw Open. 2025 Sep 2;8(9):e2534612. doi: 10.1001/jamanetworkopen.2025.34612. Erratum in: JAMA Netw Open. 2025 Dec 1;8(12):e2554305. doi: 10.1001/jamanetworkopen.2025.54305. PMID: 41026491; PMCID: PMC12485642.
Clinical benefit and cost effectiveness of adding life-time low-dose colchicine as secondary prevention following coronary artery bypass grafting surgery. Ponnana SR, Mahalwar G, Holtrop J, Hageman SHJ, Zhang T, Sirasapalli SK, Moorthy S, Chen Z, Dazard JE, Al-Kindi S, Elgudin Y, Sattar N, Rajagopalan S, Deo SV. Am Heart J Plus. 2025 Jul 16;57:100580. doi: 10.1016/j.ahjo.2025.100580. PMID: 40727715; PMCID: PMC12303075.
Non-traditional socio-environmental and geospatial determinants of Alzheimer's disease-related dementia mortality. Moorthy S, Dazard JE, Chen Z, Charak R, Palanivel S, Deo S, Al-Kindi SG, Rajagopalan S. Sci Total Environ. 2025 Jul 1;984:179745. doi: 10.1016/j.scitotenv.2025.179745. Epub 2025 May 26. PMID: 40424712.
Climate Vulnerability and Cardiovascular-Kidney-Metabolic Disease in the United States. Vieira de Oliveira Salerno PR, Lewis PGT, Chen Z, Dazard JE, Ganatra S, Ahmed EN, Nasir K, Deo SV, Rajagopalan S, Al-Kindi S. J Am Heart Assoc. 2025 Jun 3;14(11):e038251. doi: 10.1161/JAHA.124.038251. Epub 2025 May 26. PMID: 40417800; PMCID: PMC12229176.
The built environment and adverse cardiovascular events in US veterans with cardiovascular disease. Moorthy S, Chen Z, Zhang T, Ponnana SR, Sirasapalli SK, Shivanantham K, Khraishah H, Dazard JE, Al-Kindi SG, Deo SV, Rajagopalan S. Sci Total Environ. 2025 Jun 10;980:179596. doi: 10.1016/j.scitotenv.2025.179596. Epub 2025 May 3. PMID: 40319806.
Environmental Hypertensionology and the Mosaic Theory of Hypertension. Rajagopalan S, Brook RD, Münzel T. Hypertension. 2025 Apr;82(4):561-572. doi: 10.1161/HYPERTENSIONAHA.124.18733. Epub 2025 Feb 19. PMID: 39968647; PMCID: PMC11975430.
Composite socio-environmental risk score for cardiovascular assessment: An explainable machine learning approach. Chen Z, Dazard JE, Salerno PRVO, Sirasapalli SK, Makhlouf MH, Rajagopalan S, Al-Kindi S. Am J Prev Cardiol. 2025 Mar 17;22:100964. doi: 10.1016/j.ajpc.2025.100964. PMID: 40200918; PMCID: PMC11976227.
Deep Learning Analysis of Google Street View to Assess Residential Built Environment and Cardiovascular Risk in a U.S. Midwestern Retrospective Cohort. Chen Z, Salerno PRVO, Dazard JE, Makhlouf MH, Deo S, Rajagopalan S, Al-Kindi S. Eur J Prev Cardiol. 2025 Feb 4:zwaf038. doi: 10.1093/eurjpc/zwaf038. Epub ahead of print. PMID: 39903569; PMCID: PMC12319116.
AI-Facilitated Assessment of Built Environment Using Neighborhood Satellite Imagery and Cardiovascular Risk. Chen Z, Vieira de Oliveira Salerno PR, Dazard JE, Kumar Sirasapalli S, Makhlouf MHE, Motairek I, Moorthy S, Al-Kindi S, Rajagopalan S. J Am Coll Cardiol. 2024 Oct 29;84(18):1733-1744. doi: 10.1016/j.jacc.2024.08.053. PMID: 39443017; PMCID: PMC12093321.
Thoracic Surgery Deserts in the United States: A Geospatial Analysis. Salerno PRVO, Chen Z, Vieira de Oliveira Salerno J, Motairek I, Dazard JE, Deo S, Rajagopalan S, Al-Kindi S. Chest. 2024 Sep;166(3):649-652. doi: 10.1016/j.chest.2024.01.043. Epub 2024 Jan 30. PMID: 38301743.
Mineralocorticoid Receptor Antagonism Prevents Aortic Plaque Progression and Reduces Left Ventricular Mass and Fibrosis in Patients With Type 2 Diabetes and Chronic Kidney Disease: The MAGMA Trial. Rajagopalan S, Dobre M, Dazard JE, Vergara-Martel A, Connelly K, Farkouh ME, Gaztanaga J, Conger H, Dever A, Razavi-Nematollahi L, Fares A, Pereira G, Edwards-Glenn J, Cameron M, Cameron C, Al-Kindi S, Brook RD, Pitt B, Weir M. Circulation. 2024 Aug 27;150(9):663-676. doi: 10.1161/CIRCULATIONAHA.123.067620. Epub 2024 Aug 12. PMID: 39129649; PMCID: PMC11503525.
Historical neighborhood redlining and bystander CPR disparities in out-of-hospital cardiac arrest. Motairek I, Rvo Salerno P, Chen Z, Deo S, Makhlouf MHE, Al-Araji R, Rajagopalan S, Nasir K, Al-Kindi S; CARES Surveillance Group. Resuscitation. 2024 Aug;201:110264. doi: 10.1016/j.resuscitation.2024.110264. Epub 2024 Jun 6. PMID: 38851447; PMCID: PMC12046434.
Geographic proximity to cardiovascular clinical trial sites: A National analysis in the United States. Salerno PRVO, Bourges-Sevenier B, Chen Z, Pereira GTR, Deo S, Nasir K, Rajagopalan S, Al-Kindi S. Curr Probl Cardiol. 2024 Aug;49(8):102683. doi: 10.1016/j.cpcardiol.2024.102683. Epub 2024 May 23. PMID: 38795807; PMCID: PMC12046433.
Deep Learning-Based Assessment of Built Environment From Satellite Images and Cardiometabolic Disease Prevalence. Chen Z, Dazard JE, Khalifa Y, Motairek I, Kreatsoulas C, Rajagopalan S, Al-Kindi S. JAMA Cardiol. 2024 Jun 1;9(6):556-564. doi: 10.1001/jamacardio.2024.0749. PMID: 38691380; PMCID: PMC11063925.
Artificial intelligence-based assessment of built environment from Google Street View and coronary artery disease prevalence. Chen Z, Dazard JE, Khalifa Y, Motairek I, Al-Kindi S, Rajagopalan S. Eur Heart J. 2024 May 7;45(17):1540-1549. doi: 10.1093/eurheartj/ehae158. PMID: 38544295; PMCID: PMC11075932.
Transportation-Related Carbon Footprint of Coronary Heart Disease Ambulatory Care in the United States. R V O Salerno P, Chen Z, Bourges-Sevenier B, Qian A, Deo S, Nasir K, Rajagopalan S, Al-Kindi S. Circ Res. 2024 Apr 26;134(9):1218-1220. doi: 10.1161/CIRCRESAHA.124.324330. Epub 2024 Apr 25. PMID: 38662867; PMCID: PMC11047758.
Understanding the Cardiovascular and Metabolic Health Effects of Air Pollution in the Context of Cumulative Exposomic Impacts. Khraishah H, Chen Z, Rajagopalan S. Circ Res. 2024 Apr 26;134(9):1083-1097. doi: 10.1161/CIRCRESAHA.124.323673. Epub 2024 Apr 25. PMID: 38662860; PMCID: PMC11253082.
The Urban Environment and Cardiometabolic Health. Rajagopalan S, Vergara-Martel A, Zhong J, Khraishah H, Kosiborod M, Neeland IJ, Dazard JE, Chen Z, Munzel T, Brook RD, Nieuwenhuijsen M, Hovmand P, Al-Kindi S. Circulation. 2024 Apr 16;149(16):1298-1314. doi: 10.1161/CIRCULATIONAHA.123.067461. Epub 2024 Apr 15. PMID: 38620080; PMCID: PMC11093754.
Air pollution exposure and cardiometabolic risk. Rajagopalan S, Brook RD, Salerno PRVO, Bourges-Sevenier B, Landrigan P, Nieuwenhuijsen MJ, Munzel T, Deo SV, Al-Kindi S. Lancet Diabetes Endocrinol. 2024 Mar;12(3):196-208. doi: 10.1016/S2213-8587(23)00361-3. Epub 2024 Feb 1. PMID: 38310921; PMCID: PMC11264310.
Mapping Geographic Proximity to Cardiologists Across the United States. Motairek I, Chen Z, Makhlouf MHE, Deo S, Salerno PRVO, Mentias A, Nasir K, Rajagopalan S, Al-Kindi SG. Circ Cardiovasc Qual Outcomes. 2023 Oct;16(10):e010133. doi: 10.1161/CIRCOUTCOMES.123.010133. Epub 2023 Sep 12. PMID: 37698011; PMCID: PMC10592115.
Geographical Patterns and Risk Factor Association of Cardio-Oncology Mortality in the United States. Motairek I, Dong W, Salerno PR, Janus SE, Ganatra S, Chen Z, Guha A, Makhlouf MH, Hassani NS, Rajagopalan S, Al-Kindi SG. Am J Cardiol. 2023 Aug 15;201:150-157. doi: 10.1016/j.amjcard.2023.06.037. Epub 2023 Jun 27. PMID: 37385168; PMCID: PMC10529631.
Built Environment Features Obtained from Google Street View Are Associated with Coronary Artery Disease Prevalence: A Deep-Learning Framework. Chen Z, Khalifa Y, Dazard JE, Motairek I, Rajagopalan S, Al-Kindi S. medRxiv [Preprint]. 2023 Mar 29:2023.03.28.23287888. doi: 10.1101/2023.03.28.23287888. PMID: 37034698; PMCID: PMC10081432.
Neighborhood Walkability and Cardiovascular Risk in the United States. Makhlouf MHE, Motairek I, Chen Z, Nasir K, Deo SV, Rajagopalan S, Al-Kindi SG. Curr Probl Cardiol. 2023 Mar;48(3):101533. doi: 10.1016/j.cpcardiol.2022.101533. Epub 2022 Dec 5. PMID: 36481391; PMCID: PMC9892210.
Particulate Matter Air Pollution and Long-Term Outcomes in Patients Undergoing Percutaneous Coronary Intervention. Motairek I, Deo SV, Elgudin Y, McAllister DA, Brook RD, Chen Z, Su J, Rao SV, Rajagopalan S, Al-Kindi S. JACC Adv. 2023 Feb 24;2(3):100285. doi: 10.1016/j.jacadv.2023.100285. PMID: 38939589; PMCID: PMC11198626.
Historical Neighborhood Redlining and Contemporary Environmental Racism. Motairek I, Chen Z, Makhlouf MHE, Rajagopalan S, Al-Kindi S. Local Environ. 2023;28(4):518-528. doi: 10.1080/13549839.2022.2155942. Epub 2022 Dec 10. PMID: 37588138; PMCID: PMC10427113.
The NIEHS TaRGET II Consortium and environmental epigenomics. Wang T, Pehrsson EC, Purushotham D, Li D, Zhuo X, Zhang B, Lawson HA, Province MA, Krapp C, Lan Y, Coarfa C, Katz TA, Tang WY, Wang Z, Biswal S, Rajagopalan S, Colacino JA, Tsai ZT, Sartor MA, Neier K, Dolinoy DC, Pinto J, Hamanaka RB, Mutlu GM, Patisaul HB, Aylor DL, Crawford GE, Wiltshire T, Chadwick LH, Duncan CG, Garton AE, McAllister KA; TaRGET II Consortium, Bartolomei MS, Walker CL, Tyson FL. Nat Biotechnol. 2018 Mar 6;36(3):225-227. doi: 10.1038/nbt.4099.
Short-Term Blood Pressure Responses to Ambient Fine Particulate Matter Exposures at the Extremes of Global Air Pollution Concentrations. Huang W, Wang L, Li J, Liu M, Xu H, Liu S, Chen J, Zhang Y, Morishita M, Bard RL, Harkema JR, Rajagopalan S, Brook RD. Am J Hypertens. 2018 Feb 2. doi: 10.1093/ajh/hpx216. [Epub ahead of print] PMID: 29409056
2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults. A report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Brook RD, Rajagopalan S.J Am Soc Hypertens. 2018 Mar;12(3) PMID: 29396104
Exercise-Induced Pulmonary Hypertension: Translating Pathophysiological Concepts Into Clinical Practice. Naeije R, Saggar R, Badesch D, Rajagopalan S, Gargani L, Rischard F, Ferrara F, Marra AM, D' Alto M, Bull TM, Saggar R, Grünig E, Bossone E.Chest. 2018 Jan 31. pii: S0012-3692(18)30161-2. doi: 10.1016/j.chest.2018.01.022. PMID: 29382472
CITED2 restrains pro-inflammatory macrophage activation and response. Kim GD, Das R, Rao X, Zhong J, Deiuliis JA, Ramirez-Bergeron DL, Rajagopalan S, Mahabeleshwar GH. Mol Cell Biol. 2017 Dec 4. pii: MCB.00452-17. doi: 10.1128/MCB.00452-17. PMID: 29203644
Noncoding RNAs in Cardiovascular Disease: Pathological Relevance and Emerging Role as Biomarkers and Therapeutics. Gangwar RS, Rajagopalan S, Natarajan R, Deiuliis JA. Am J Hypertens. 2018 Jan 12;31 PMID: 29186297
Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes. Rajagopalan S, Brook R. N Engl J Med. 2017 Nov 23;377(21):2098-9.No abstract available. PMID: 29182250
Inhalation Exposure to PM2.5 Counteracts Hepatic Steatosis in Mice Fed High-fat Diet by Stimulating Hepatic Autophagy. Qiu Y, Zheng Z, Kim H, Yang Z, Zhang G, Shi X, Sun F, Peng C, Ding Y, Wang A, Chen LC, Rajagopalan S, Sun Q, Zhang K. Sci Rep. 2017 Nov 24;7(1):16286. doi: 10.1038/s41598-017-16490-3. PMID: 29176715 Free PMC Article
Monocyte DPP4 Expression in Human Atherosclerosis Is Associated With Obesity and Dyslipidemia. Rao X, Deiuliis JA, Mihai G, Varghese J, Xia C, Frieman MB, Sztalryd C, Sun XJ, Quon MJ, Taylor SI, Rajagopalan S, Zhong J.Diabetes Care. 2018 Jan;41(1)Epub 2017 Nov 10. PMID: 29127241
Effect of Particulate Matter Air Pollution on Cardiovascular Oxidative Stress Pathways. Rao X, Zhong J, Brook RD, Rajagopalan S. Antioxid Redox Signal. 2018 Mar 20;28(9):797-818. Epub 2017 Dec 12. PMID: 29084451
Extreme levels of ambient air pollution adversely impact cardiac and central aortic hemodynamics: the AIRCMD-China study. Liu S, Brook RD, Huang W, Fan Z, Xu H, Wu R, Sun Z, Zhao X, Ruan Y, Yan J, Sun L, Liang R, Lian H, Gu D, Rajagopalan S. J Am Soc Hypertens. 2017 Nov;11(11):754-761.e3. doi: 10.1016/j.jash.2017.09.009. Epub 2017 Sep 28. PMID: 29031802
The Role of the Mineralocorticoid Receptor in Inflammation: Focus on Kidney and Vasculature. Belden Z, Deiuliis JA, Dobre M, Rajagopalan S. Am J Nephrol. 2017;46(4):298-314. Epub 2017 Oct 10. PMID: 29017166
Personal-level exposure to environmental temperature is a superior predictor of endothelial-dependent vasodilatation than outdoor-ambient level. Ejike C, Wang L, Liu M, Wang W, Morishita M, Bard RL, Huang W, Harkema J, Rajagopalan S, Brook RD. J Am Soc Hypertens. 2017 Nov;11(11):746-753.e1. Epub 2017 Sep 28. PMID: 28989070
Cardiovascular evaluation and management of iron overload cardiomyopathy in sickle cell disease. Ginwalla M, AlMasoud A, Tofovic D, Alin T, Al-Kindi S, Oliveira G, Rajagopalan S, Schilz R, Little J. Am J Hematol. 2018 Jan;93(1)Epub 2017 Oct 23. PMID: 28971490
Design of the exercise MRI evaluation of HIV-pulmonary arterial hypertension longitudinal determinants (EXALTED) trial. Alaiti MA, Goud A, Ramani G, Bagchi S, Al-Kindi S, Sawicki S, Longenecker C, Jenkins T, Pauza D, Park M, McComsey G, Simonetti O, Hoit B, Rajagopalan S. J Cardiovasc Med (Hagerstown). 2017 Nov;18(11):888-896. PMID: 28937582
Stressed About Air Pollution: Time for Personal Action. Brook RD, Rajagopalan S. Circulation. 2017 Aug 15;136(7):628-631. PMID: 28808145
Cancer risks of anti-hyperglycemic drugs for type 2 diabetes treatment - a clinical appraisal. Vora J, Ray K, Kosiborod M, Poulter NR, Rajagopalan S, Leiter LA. J Diabetes Complications. 2017 Sep;31(9):1451-1457. Epub 2017 Jun 15. Review. PMID: 28655490
Air Pollution and Cardiometabolic Disease: An Update and Call for Clinical Trials. Brook RD, Newby DE, Rajagopalan S. Am J Hypertens. 2017 Dec 8;31(1):1-10. doi: 10.1093/ajh/hpx109. PMID: 28655143
The regulatory role of DPP4 in atherosclerotic disease. Duan L, Rao X, Xia C, Rajagopalan S, Zhong J. Cardiovasc Diabetol. 2017 Jun 15;16(1):76. Review. PMID: 28619058 Free PMC Article
Design of the Magnetic Resonance Imaging Evaluation of Mineralocorticoid Receptor Antagonism in Diabetic Atherosclerosis (MAGMA) Trial. Rajagopalan S, Alaiti MA, Broadwater K, Goud A, Gaztanaga J, Connelly K, Fares A, Shirazian S, Kreatsoulas C, Farkouh M, Dobre M, Fink JC, Weir MR. Clin Cardiol. 2017 Sep;40(9) Epub 2017 May 26.