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Umut Gurkan, PhD

Professor
Department of Mechanical and Aerospace Engineering
Case School of Engineering
Member
Population and Cancer Prevention Program
Case Comprehensive Cancer Center

Improves human health via research in cell mechanics and microtechnology to develop biosensors and point-of-care diagnostic systems.

Biomanufacturing and Microfabrication Lab

Other Affiliations

Professor (Secondary Appointment), Department of Biomedical Engineering, Case Western Reserve University

Chief Scientist in Microfabrication, Hemex Health Inc.

Director of Technology, BioChip Labs Inc.

Co-Director, Translational Fellows Program

Clinical and Translational Science (CTS) Annual Pilot Award Program Lead at Clinical and Translational Science Collaborative of Northern Ohio

Selected Awards

Professor Gurkan’s national and international honors include the National Science Foundation CAREER Award, the American Society for Engineering Education Curtis W. McGraw Research Award Finalist, Translational Research Featured New Investigator Award, the Biomedical Engineering Society Rising Star Award, MIT Technology Review Innovator under 35 Award, the Doris Duke Innovations in Clinical Research Award, NHLBI feature in Today’s Faces of Sickle Cell Disease, NHLBI Hope for Sickle Cell Disease Challenge Award, NIH Technology Accelerator Challenge Award, the Wiederhielm Award from the Microcirculatory Society, National Academies US-Africa Frontiers Symposium invited attendee, National Academies Arab-American Frontiers Symposium co-chair, USPTO Patents for Humanity recognition, and USFDA Breakthrough Device Designation. Professor Gurkan’s institutional honors at Case Western Reserve University include the Faculty Distinguished Research Award, Research Innovator of the Year Award, Faculty Innovator Award, Excellence in Device Innovation Award, Ingenuity Award, International Activity Award, Case School of Engineering Research Award, and Belcher-Weir Family Pediatric Innovation Award.

Teaching Information

Teaching Interests

EMAE 370 Design of Mechanical Elements

EMAE 456 / EBME 456 Biomanufacturing and Micro-Electro-Mechanical System (BioMEMS)

Research Information

Research Interests

Umut A. Gurkan is leading the CASE Biomanufacturing and Microfabrication Laboratory (CASE-BML).  Dr. Gurkan’s research is focused on microcirculation, vascular biology, red blood cells, hemoglobin, cell/gene therapies, and the design, development, and translation of microfluidic systems, point-of-care diagnostics for blood disorders, infectious diseases, and cancer. His research program aims to achieve global equitable access to diagnostics and personalized medicine for all.

Dr. Gurkan’s research and inventions have led to founding of new biotechnology companies with products in global markets. Dr. Gurkan has industry roles in start-up companies as the Director of Technology at BioChip Labs Inc. and Senior Scientist at Hemex Health Inc. BioChip Labs Inc. offers commercial clinical microfluidic biomarker assays for blood disorders and cell/gene therapies. Hemex Health Inc. offers affordable point-of-care diagnostics for hemoglobin disorders, anemia, and infectious diseases. Professor Gurkan has led international clinical studies on technology translation in the United States, Africa, Southeast Asia, Middle East, and India. His group invented the Gazelle Hb Variant technology, an affordable point-of-care screening test for sickle cell anemia, thalassemia, and other common hemoglobin disorders.

Patents Pending

2015, "Microfluidic Biochip Electrophoresis To Monitor and Diagnose Sickle Cell Disease" PCT/US2015/042907, Umut Gurkan, Yunus Alapan, Jane Little, & Connie Piccone.
2015, "Sensor apparatus, systems and methods of making same" 14/728,642, Umut Gurkan, Pedram Mohseni, Michael Suster, & M Bakshiani.
2013, "Portal and method for management of dialysis therapy" 2013/3/24, Umut Gurkan, Utkan Demirci, & Derya Yellin.

Awards and Honors

Wiederhielm Award for the Top Cited Original Research Article in Microcirculation Journal
2023
Microcirculatory Society
Faculty Distinguished Research Award
2023
Case Western Reserve University
Research Innovator of the Year
2023
Case Western Reserve University
U.S.-Africa Frontiers of Science, Engineering, and Medicine Symposium Invitation
2022
National Academies of Sciences Engineering and Medicine (NASEM)
Elected Fellow
2022
American Institute for Medical and Biological Engineering (AIMBE)
Excellence in Device Innovation Award
2022
Case Western Reserve University
Faculty Innovator Award
2022
Case Western Reserve University
Ingenuity Award
2022
Case Western Reserve University
Elected Member of the New Voices in Sciences, Engineering, and Medicine
2021
National Academies of Sciences Engineering and Medicine (NASEM)
Today’s Faces of Sickle Cell Disease
2021
featured by the National Heart Lung and Blood Institute
Hope for Sickle Cell Disease Challenge Winner
2021
National Heart Lung and Blood Institute
Curtis W. McGraw Research Award Finalist
2021
American Society for Engineering Education (ASEE)

Professional Memberships

American Society of Mechanical Engineers (ASME), Member
IEEE Engineering in Medicine and Biology Society (EMBS), Member
Biomedical Engineering Society (BMES), Member
American Society of Hematology (ASH), Member
American Electrophoresis Society (AES), Member
National Academy of Inventors (NAI), Senior Member
American Institute for Medical and Biological Engineering (AIMBE), Fellow

Publications

Google Scholar

Publications

Freeman, B., Maji, D., Nrasimhan, S., Ahuja, S., Little, J., Suster, M., Mohseni, P., & Gurkan, U. (2021). Microfluidic electrical impedance assessment of red blood cell-mediated microvascular occlusion.. Lab on a chip.
Gurkan, U. (2021). Biophysical and rheological biomarkers of red blood cell physiology and pathophysiology.. Current opinion in hematology.
Freeman, B., Kucukal, E., Nrasimhan, S., Bode, A., Little, J., & Gurkan, U. (2021). Standardized microfluidic assessment of red blood cell-mediated microcapillary occlusion: Association with clinical phenotype and hydroxyurea responsiveness in sickle cell disease.. Microcirculation (New York, N.Y. : 1994), 28 (2), e12662.
Kucukal, E., Man, Y., Hill, A., Liu, S., Bode, A., Bakhshiani, M., Kadambi, J., Little, J., & Gurkan, U. (2020). Whole blood viscosity and red blood cell adhesion: Potential biomarkers for targeted and curative therapies in sickle cell disease. American Journal of Hematology, 95 (11), 1246-1256.
ElKabbash, M., Sreekanth, K., Fraiwan, A., Cole, J., Alapan, Y., Letsou, T., Hoffman, N., Guo, C., Sankaran, R., Gurkan, U., Hinczewski, M., & Strangi, G. (2020). Ultrathin-film optical coating for angle-independent remote hydrogen sensing. Measurement Science and Technology, 31 (11).
ElKabbash, M., Sreekanth, K., Fraiwan, A., Cole, J., Alapan, Y., Letsou, T., Hoffman, N., Guo, C., Sankaran, R., Gurkan, U., Hinczewski, M., & Strangi, G. (2020). Ultrathin-film optical coating for angle-independent remote hydrogen sensing. Measurement Science and Technology, 31 (11).
Man, Y., Kucukal, E., Bakhshiani, M., Bode, A., Little, J., & Gurkan, U. (2020). Standardized microfluidic assessment of red blood cell mediated microcapillary occlusion: association with clinical phenotype and hydroxyurea responsiveness in sickle cell disease. Microcirculation.
Kucukal, E., Man, Y., Quinn, E., Tewari, N., Bakhshiani, M., Ilich, A., Key, N., Little, J., & Gurkan, U. (2020). Red blood cell adhesion to ICAM-1 is mediated by fibrinogen and is associated with right-to-left shunts in sickle cell disease. Blood Advances, 4 (15), 3688-3698.
Noomuna, P., Risinger, M., Zhou, S., Seu, K., Man, Y., Bakhshiani, M., Sheik, D., Wan, J., Little, J., Gurkan, U., Turrini, F., Kalfa, T., & Low, P. (2020). Inhibition of Band 3 tyrosine phosphorylation: a new mechanism for treatment of sickle cell disease. British Journal of Haematology, 190 (4), 599-609.
Man, Y., Goreke, U., Kucukal, E., Hill, A., Bakhshiani, M., Liu, S., Bode, A., Solis-Fuentes, A., Nayak, L., Little, J., & Gurkan, U. (2020). Leukocyte adhesion to P-selectin and the inhibitory role of Crizanlizumab in sickle cell disease: A standardized microfluidic assessment. Blood Cells, Molecules, and Diseases, 83
Hasan, M., Fraiwan, A., Nrasimhan, S., Alapan, Y., Adelung, R., Akkus, A., Xu, J., Rezac, A., Kocmich, N., Creary, M., Oginni, T., Olanipekun, G., Hassan-Hanga, F., Jibir, B., Gambo, S., Verma, A., Bharti, P., Riolueang, S., Ngimhung, T., Suksangpleng, T., Thota, P., Werner, G., Shanmugam, R., Adas, S., Viprakasit, V., Piccone, C., Little, J., Obaro, S., & Gurkan, U. (2020). Paper-based microchip electrophoresis for point-of-care hemoglobin testing.. The Analyst, 145 (7), 2525-2542.
Man, Y., Kucukal, E., Bakhshiani, M., Watson, Q., Bosch, J., Zimmerman, P., Little, J., & Gurkan, U. (2020). Microfluidic assessment of red blood cell mediated microvascular occlusion. Lab on a Chip, 20 (12), 2086-2099.
Hasan, M., Fraiwan, A., Bakhshiani, M., Alapan, Y., Ung, R., Akkus, A., Xu, J., Rezac, A., Kocmich, N., Creary, M., Oginni, T., Olanipekun, G., Hassan-Hanga, F., Jibir, B., Gambo, S., Verma, A., Bharti, P., Riolueang, S., Ngimhung, T., Suksangpleng, T., Thota, P., Werner, G., Shanmugam, R., Das, A., Viprakasit, V., Piccone, C., Little, J., Obaro, S., & Gurkan, U. (2020). Paper-based microchip electrophoresis for point-of-care hemoglobin testing. The Analyst, 145 (7), 2525-2542.
Chatterjee, S., Shkondin, E., Takayama, O., Fisher, A., Fraiwan, A., Gurkan, U., Lavrinenko, A., & Strangi, G. (2020). Hydrogen gas sensing using aluminum doped ZnO metasurfaces. Nanoscale Advances, 2 (8), 3452-3459.
Yuan, C., Quinn, E., Kucukal, E., Kapoor, S., Gurkan, U., & Little, J. (2019). Priapism, hemoglobin desaturation, and red blood cell adhesion in men with sickle cell anemia. Blood Cells, Molecules, and Diseases, 79
ElKabbash, M., Sreekanth, K., Alapan, Y., Kim, M., Cole, J., Fraiwan, A., Letsou, T., Li, Y., Guo, C., Sankaran, R., Gurkan, U., Hinczewski, M., & Strangi, G. (2019). Hydrogen Sensing Using Thin-Film Perfect Light Absorber. ACS Photonics, 6 (8), 1889-1894.
ElKabbash, M., Sreekanth, K., Alapan, Y., Kim, M., Cole, J., Fraiwan, A., Letsou, T., Li, Y., Guo, C., Sankaran, R., Gurkan, U., Hinczewski, M., & Strangi, G. (2019). Hydrogen Sensing Using Thin-Film Perfect Light Absorber. ACS Photonics, 6 (8), 1889-1894.
Akkaya, B., Kucukal, E., Little, J., & Gurkan, U. (2019). Mercury leads to abnormal red blood cell adhesion to laminin mediated by membrane sulfatides. Biochimica et Biophysica Acta - Biomembranes, 1861 (6), 1162-1171.
Hasan, M., Radwan, A., Kim, M., Kucukal, E., Maji, D., Pashaei, V., Chung, C., Kakkar, A., & Gurkan, U. (2019). Emerging micro and nanotechnologies in neuroscience: Devices, fabrication methods, and implementation in monitoring of neural activity and drug delivery. TECHNOLOGY, 07 (03n04), 57-83.
Benson, B., Li, L., Myers, J., Dorand, R., Gurkan, U., Huang, A., & Ransohoff, R. (2018). Biomimetic post-capillary venule expansions for leukocyte adhesion studies. Scientific Reports, 8 (1).
Maji, D., De La Fuente, M., Kucukal, E., Sekhon, U., Schmaier, A., Sen Gupta, A., Gurkan, U., Nieman, M., Stavrou, E., Mohseni, P., & Suster, M. (2018). Assessment of Whole Blood Coagulation with a Microfluidic Dielectric Sensor. Journal of Thrombosis and Haemostasis, 16 (10), 2050-2056.
Kucukal, E., Ilich, A., Key, N., Little, J., & Gurkan, U. (2018). Red Blood Cell Adhesion to Heme-Activated Endothelial Cells Reflects Clinical Phenotype in Sickle Cell Disease. American Journal of Hematology, 93 (8), 1050-1060.
Stavrou, E., Fang, C., Bane, K., Long, A., Naudin, C., Kucukal, E., Gandhi, A., Brett-Morris, A., Mumaw, M., Izadmehr, S., Merkulova, A., Reynolds, C., Alhalabi, O., Nayak, L., Yu, W., Qu, C., Meyerson, H., Dubyak, G., Gurkan, U., Nieman, M., Sen Gupta, A., Renn�, T., & Schmaier, A. (2018). Factor XII and uPAR upregulate neutrophil functions to influence wound healing. Journal of Clinical Investigation, 128 (3), 944-959.
Kucukal, E., Little, J., & Gurkan, U. (2018). Shear dependent red blood cell adhesion in microscale flow. Integrative Biology, 10 (4), 194-206.
Fan, J., Liao, H., Ke, R., Kucukal, E., Gurkan, U., Shen, X., Lu, J., & Li, B. (2018). A monolithic Lagrangian meshfree scheme for Fluid-Structure Interaction problems within the OTM framework. COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING, 337 , 198-219.
Webster-Wood, V., Akkus, O., Gurkan, U., Chiel, H., & Quinn, R. D. (2017). Organismal engineering: Toward a robotic taxonomic key for devices using organic materials. Science Robotics, 2 (12).
Sreekanth, K., ElKabbash, M., Alapan, Y., Ilker, E., Hinczewski, M., Gurkan, U., & Strangi, G. (2017). Hyperbolic metamaterials-based plasmonic biosensor for fluid biopsy with single molecule sensitivity. EPJ Applied Metamaterials, 4
Maji, D., Suster, M., Kucukal, E., Sekhon, U., Gupta, A., Gurkan, U., Stavrou, E., & Mohseni, P. (2017). ClotChip: A Microfluidic Dielectric Sensor for Point-of-Care Assessment of Hemostasis. IEEE Transactions on Biomedical Circuits and Systems.
Kim, M., Alapan, Y., Adhikari, A., Little, J., & Gurkan, U. (2017). Hypoxia enhanced adhesion of red blood cells in microscale flow. Microcirculation.
Valiyaveedu Sreekanth, K., ElKabbash, M., Alapan, Y., Ilker, E., Hinczewski, M., Gurkan, U., & Strangi, G. (2017). Erratum to: Hyperbolic metamaterials-based plasmonic biosensor for fluid biopsy with single molecule sensitivity. EPJ Applied Metamaterials, 4
Krebs, J., Alapan, Y., Dennstedt, B., Wera, G., & Gurkan, U. (2017). Microfluidic processing of synovial fluid for cytological analysis. BIOMEDICAL MICRODEVICES, 19 (2).
Alapan, Y., Kim, C., Adhikari, A., Gray, K., Gurkan Cavusoglu, E., Little, J., & Gurkan, U. (2016). Sickle Cell Disease Biochip: a functional red blood cell adhesion assay for monitoring sickle cell disease. Transl Res, 173 , 74 - 91.
Sreekanth, K., ElKabbash, M., Alapan, Y., Rashed, A., Gurkan, U., & Strangi, G. (2016). A multiband perfect absorber based on hyperbolic metamaterials. Scientific Reports [20452322], 6
Sreekanth, K., Alapan, Y., ElKabbash, M., Wen, A., Ilker, E., Hinczewski, M., Gurkan, U., Steinmetz, N., & Strangi, G. (2016). Enhancing the Angular Sensitivity of Plasmonic Sensors Using Hyperbolic Metamaterials. Advanced Optical Materials [21951071], 4 (11), 1767-1772.
Alapan, Y., Matsuyama, Y., Little, J., & Gurkan, U. (2016). Dynamic deformability of sickle red blood cells in microphysiological flow. Technology [23395478], 4 (2), 71-79.
Sreekanth, K., Alapan, Y., ElKabbash, M., Ilker, E., Hinczewski, M., Gurkan, U., De Luca, A., & Strangi, G. (2016). Extreme sensitivity biosensing platform based on hyperbolic metamaterials. Nature Materials [14761122], 15 (6), 621-627.
Alapan, Y., Younesi, M., Akkus, O., & Gurkan, U. (2016). Anisotropically Stiff 3D Micropillar Niche Induces Extraordinary Cell Alignment and Elongation. Advanced Healthcare Materials [21922640], 5 (15), 1884-1892.
Alapan, Y., Fraiwan, A., Kucukal, E., Hasan, M., Ung, R., Kim, M., Odame, I., Little, J., & Gurkan, U. (2016). Emerging Point-of-Care Technologies for Sickle Cell Disease Screening and Monitoring. Expert Review of Medical Devices [17434440], 13 (12), 1073-1093.
Alapan, Y., Kim, C., Adhikari, A., Gray, K., Gurkan-Cavusoglu, E., Little, J., & Gurkan, U. (2016). Sickle cell disease biochip: a functional red blood cell adhesion assay for monitoring sickle cell disease. Translational Research [19315244], 173 , 74-91.e8.
Alapan, Y., Younesi, M., Akkus, O., & Gurkan, U. (2016). Cell-Aligning Substrates: Anisotropically Stiff 3D Micropillar Niche Induces Extraordinary Cell Alignment and Elongation (Adv. Healthcare Mater. 15/2016). Advanced Healthcare Materials [21922640], 5 (15), 1833-1833.
Alapan, Y., Icoz, K., & Gurkan, U. (2015). Micro- and nanodevices integrated with biomolecular probes.. Biotechnology advances, 33 (8), 1727-43.
Maji, D., Suster, M., Stavrou, E., Gurkan, U., & Mohseni, P. (2015). Monitoring time course of human whole blood coagulation using a microfluidic dielectric sensor with a 3D capacitive structure.. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2015 , 5904-7.
Shafiee, H., Asghar, W., Inci, F., Yuksekkaya, M., Jahangir, M., Zhang, M., Durmus, N., Gurkan, U., Kuritzkes, D., & Demirci, U. (2015). Paper and flexible substrates as materials for biosensing platforms to detect multiple biotargets.. Scientific reports, 5 , 8719.
Guven, S., Lindsey, J., Poudel, I., Chinthala, S., Nickerson, M., Gerami-Naini, B., Gurkan, U., Kanchanaharuthai, A., & Demirci, U. (2015). Functional maintenance of differentiated embryoid bodies in microfluidic systems: a platform for personalized medicine.. Stem cells translational medicine, 4 (3), 261-8.
Alapan, Y., Hasan, M., Shen, R., & Gurkan, U. (2015). Three-Dimensional Printing Based Hybrid Manufacturing of Microfluidic Devices. Journal of Nanotechnology in Engineering and Medicine, 6 (2), 021007.
Alapan, Y., Little, J., & Gurkan, U. (2014). Heterogeneous red blood cell adhesion and deformability in sickle cell disease.. Scientific reports, 4 , 7173.
Unal, M., Alapan, Y., Jia, H., Varga, A., Angelino, K., Aslan, M., Sayin, I., Han, C., Jiang, Y., Zhang, Z., & Gurkan, U. (2014). Micro and Nano-scale Technologies for Cell Mechanics. Nanobiomedicine, 1 (4), 7173.
El Assal, R., Guven, S., Gurkan, U., Gozen, I., Shafiee, H., Dalbeyler, S., Abdalla, N., Thomas, D., Fuld, W., Illigens, B., Estanislau, J., Khoory, J., Kaufman, R., Zylberberg, C., Lindeman, N., Wen, Q., Ghiran, I., & Demirci, U. (2014). Bio-inspired cryo-ink preserves red blood cell phenotype and function during nanoliter vitrification.. Advanced materials, 26 (33), 5815-22.
Kilinc, S., Gurkan, U., Guven, S., Koyuncu, G., Tang, C., Karaca, C., Ozdogan, O., Dogan, M., Tugmen, C., Palaganas, N., Bayol, U., Baran, M., Kurtulmus, Y., Pirim, I., Kebapci, E., & Demirci, U. (2014). Evaluation of epithelial chimerism after bone marrow mesenchymal stromal cell infusion in intestinal transplant patients.. Transplantation proceedings, 46 (6), 2125-32.
Wang, S., Tasoglu, S., Chen, P., Chen, M., Akbas, R., Wach, S., Ozdemir, C., Gurkan, U., Giguel, F., Kuritzkes, D., & Others, D. (2014). Micro-a-fluidics ELISA for Rapid CD4 Cell Count at the Point-of-Care. Scientific reports, 4
Akkaynak, D., Treibitz, T., Xiao, B., Gurkan, U., Allen, J., Demirci, U., & Hanlon, R. (2014). Use of commercial off-the-shelf digital cameras for scientific data acquisition and scene-specific color calibration.. Journal of the Optical Society of America. A, Optics, image science, and vision, 31 (2), 312-21.
Gurkan, U., El Assal, R., Yildiz, S., Sung, Y., Trachtenberg, A., Kuo, W., & Demirci, U. (2014). Engineering anisotropic biomimetic fibrocartilage microenvironment by bioprinting mesenchymal stem cells in nanoliter gel droplets. Molecular pharmaceutics.
Tasoglu, S., Gurkan, U., Wang, S., & Demirci, U. (2013). Manipulating biological agents and cells in micro-scale volumes for applications in medicine. Chemical Society Reviews, 42 (13), 5788–5808.
Tasoglu, S., Kavaz, D., Gurkan, U., Guven, S., Chen, P., Zheng, R., & Demirci, U. (2013). Paramagnetic Levitational Assembly of Hydrogels. Advanced Materials, 25 (8), 1081–1081.
Tasoglu, S., Safaee, H., Zhang, X., Kingsley, J., Catalano, P., Gurkan, U., Nureddin, A., Kayaalp, E., Anchan, R., Maas, R., & Others, R. (2013). Exhaustion of Racing Sperm in Nature-Mimicking Microfluidic Channels During Sorting. Small, 9 (20), 3374–3384.
Tasoglu, S., Safaee, H., Zhang, X., Kingsley, J., Catalano, P., Gurkan, U., Nureddin, A., Kayaalp, E., Anchan, R., Maas, R., & Others, R. (2013). Microfluidic Sorting: Exhaustion of Racing Sperm in Nature-Mimicking Microfluidic Channels During Sorting (Small 20/2013). Small, 9 (20), 3366–3366.
Gurkan, U., Fan, Y., Xu, F., Erkmen, B., Urkac, E., Parlakgul, G., Bernstein, J., Xing, W., Boyden, E., & Demirci, U. (2013). Simple precision creation of digitally specified, spatially heterogeneous, engineered tissue architectures. Advanced Materials, 25 (8), 1192–1198.
Rizvi, I., Gurkan, U., Tasoglu, S., Alagic, N., Celli, J., Mensah, L., Mai, Z., Demirci, U., & Hasan, T. (2013). Flow induces epithelial-mesenchymal transition, cellular heterogeneity and biomarker modulation in 3D ovarian cancer nodules. Proceedings of the National Academy of Sciences, 110 (22), E1974–E1983.
Inci, F., Tokel, O., Wang, S., Gurkan, U., Tasoglu, S., Kuritzkes, D., & Demirci, U. (2013). Nanoplasmonic Quantitative Detection of Intact Viruses from Unprocessed Whole Blood. ACS nano, 7 (6), 4733–4745.
Gurkan, U., Tasoglu, S., Kavaz, D., Demirel, M., & Demirci, U. (2012). Emerging technologies for assembly of microscale hydrogels. Advanced healthcare materials, 1 (2), 149–158.
Xu, F., Inci, F., Mullick, O., Gurkan, U., Sung, Y., Kavaz, D., Li, B., Denkbas, E., & Demirci, U. (2012). Release of magnetic nanoparticles from cell-encapsulating biodegradable nanobiomaterials. ACS nano, 6 (8), 6640–6649.
Wang, S., Inci, F., Chaunzwa, T., Ramanujam, A., Vasudevan, A., Subramanian, S., Ip, A., Sridharan, B., Gurkan, U., & Demirci, U. (2012). Portable microfluidic chip for detection of Escherichia coli in produce and blood. International journal of nanomedicine, 7 , 2591–2600.
Gurkan, U., Tasoglu, S., Akkaynak, D., Avci, O., Unluisler, S., Canikyan, S., MacCallum, N., & Demirci, U. (2012). Smart Interface Materials Integrated with Microfluidics for On-Demand Local Capture and Release of Cells. Advanced healthcare materials, 1 (5), 661–668.
Wang, S., Esfahani, M., Gurkan, U., Inci, F., Kuritzkes, D., & Demirci, U. (2012). Efficient on-chip isolation of HIV subtypes. Lab on a Chip, 12 (8), 1508–1515.
Ceyhan, E., Xu, F., Gurkan, U., Emre, A., Turali, E., El Assal, R., Acikgenc, A., Wu, C., & Demirci, U. (2012). Prediction and control of number of cells in microdroplets by stochastic modeling. Lab on a Chip, 12 (22), 4884–4893.
Gurkan, U., Golden, R., Kishore, V., Riley, C., Adamec, J., & Akkus, O. (2012). Immune and Inflammatory Pathways are Involved in Inherent Bone Marrow Ossification. Clinical Orthopaedics and Related Research®.
Gurkan, U., Anand, T., Tas, H., Elkan, D., Akay, A., Keles, H., & Demirci, U. (2011). Controlled viable release of selectively captured label-free cells in microchannels. Lab on a Chip, 11 (23), 3979–3989.
Gurkan, U., Kishore, V., Condon, K., Bellido, T., & Akkus, O. (2011). A scaffold-free multicellular three-dimensional in vitro model of osteogenesis. Calcified tissue international, 88 (5), 388–401.
Zhang, X., Catalano, P., Gurkan, U., Khimji, I., & Demirci, U. (2011). Emerging technologies in medical applications of minimum volume vitrification. Nanomedicine, 6 (6), 1115–1129.
Zhang, X., Khimji, I., Gurkan, U., Safaee, H., Catalano, P., Keles, H., Kayaalp, E., & Demirci, U. (2011). Lensless imaging for simultaneous microfluidic sperm monitoring and sorting. Lab on a Chip, 11 (15), 2535–2540.
Gurkan, U., Moon, S., Geckil, H., Xu, F., Wang, S., Lu, T., & Demirci, U. (2011). Miniaturized lensless imaging systems for cell and microorganism visualization in point-of-care testing. Biotechnology journal, 6 (2), 138–149.
Xu, F., Finley, T., Turkaydin, M., Sung, Y., Gurkan, U., Yavuz, A., Guldiken, R., & Demirci, U. (2011). The assembly of cell-encapsulating microscale hydrogels using acoustic waves. Biomaterials.
Gurkan, U., & Xu, F. (2011). Editorial: Scaffold-free cell-based approaches in biomedicine and biotechnology. Biotechnology journal, 6 (12), 1426–1427.
Gurkan, U., Krueger, A., & Akkus, O. (2011). Ossifying bone marrow explant culture as a three-dimensional mechanoresponsive in vitro model of osteogenesis. Tissue Engineering Part A, 17 (3-4), 417–428.
Moon, S., Gurkan, U., Blander, J., Fawzi, W., Aboud, S., Mugusi, F., Kuritzkes, D., & Demirci, U. (2011). Enumeration of CD4+ T-cells using a portable microchip count platform in Tanzanian HIV-infected patients. PLoS One, 6 (7), e21409.
Xu, F., Sridharan, B., Durmus, N., Wang, S., Yavuz, A., Gurkan, U., & Demirci, U. (2011). Living bacterial sacrificial porogens to engineer decellularized porous scaffolds. PloS one, 6 (4), e19344.
Zhang, X., Khimji, I., Shao, L., Safaee, H., Desai, K., Keles, H., Gurkan, U., Kayaalp, E., Nureddin, A., Anchan, R., & Others, R. (2011). Nanoliter droplet vitrification for oocyte cryopreservation. Nanomedicine, 7 (4), 553–564.
Xu, F., Wu, C., Rengarajan, V., Finley, T., Keles, H., Sung, Y., Li, B., Gurkan, U., & Demirci, U. (2011). Three-Dimensional Magnetic Assembly of Microscale Hydrogels. Advanced Materials.
Xu, F., Beyazoglu, T., Hefner, E., Gurkan, U., & Demirci, U. (2011). Automated and adaptable quantification of cellular alignment from microscopic images for tissue engineering applications. Tissue Engineering Part C: Methods, 17 (6), 641–649.
Xu, F., Sridharan, B., Wang, S., Gurkan, U., Syverud, B., & Demirci, U. (2011). Embryonic stem cell bioprinting for uniform and controlled size embryoid body formation. Biomicrofluidics, 5 (2), 022207.
Gurkan, U., Tas, H., Anand, T., & Demirci, U. (2011). Label-free and Viable Stem Cell Isolation from Peripheral Blood with a Disposable Microfluidic Chip. .
Xu, F., Wu, J., Wang, S., Durmus, N., Gurkan, U., & Demirci, U. (2011). Microengineering methods for cell-based microarrays and high-throughput drug-screening applications. Biofabrication, 3 (3), 034101.
Moon, S., Ceyhan, E., Gurkan, U., & Demirci, U. (2011). Statistical modeling of single target cell encapsulation. PloS one, 6 (7), e21580.
Sekeroglu, K., Gurkan, U., Demirci, U., & Demirel, M. (2011). Transport of a soft cargo on a nanoscale ratchet. Applied Physics Letters, 99 , 063703.
Gurkan, U., Gargac, J., & Akkus, O. (2010). The sequential production profiles of growth factors and their relations to bone volume in ossifying bone marrow explants. Tissue Engineering Part A, 16 (7), 2295–2306.
Gurkan, U., Cheng, X., Kishore, V., Uquillas, J., & Akkus, O. (2010). Comparison of morphology, orientation, and migration of tendon derived fibroblasts and bone marrow stromal cells on electrochemically aligned collagen constructs. Journal of Biomedical Materials Research Part A, 94 (4), 1070–1079.
Meldrum, R., Gurkan, U., Kattaya, S., & Akkus, O. (2009). Osteogenic Effects of Preparations of Rat Pulmonary Alveolar Macrophages Challenged with Staphylococcus Aureus. Indiana Orthopaedic Journal, 3 , 28.
Gurkan, U., & Akkus, O. (2008). The mechanical environment of bone marrow: a review. Annals of biomedical engineering, 36 (12), 1978–1991.
Cheng, X., Gurkan, U., Dehen, C., Tate, M., Hillhouse, H., Simpson, G., & Akkus, O. (2008). An electrochemical fabrication process for the assembly of anisotropically oriented collagen bundles. Biomaterials, 29 (22), 3278–3288.