A Home for Collaborative Discovery and Innovation
At Case Western Reserve, we solve pressing problems to improve our world. With the creation of the Interdisciplinary Science and Engineering Building (ISEB), our researchers will be able to take their work even further—collaborating across disciplines to drive change.
The Future of Research, In Numbers
A Historic Investment
This $300 million building represents CWRU’s largest-ever project on Case Quad—and an innovative vision for interdisciplinary research.
Making Headlines
From the day it was announced, the ISEB project has made headlines through donor commitments, inspiring ideas and more.
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October 09, 2026By assembling researchers with complementary expertise under one roof, Case Western Reserve is building the critical mass needed to move drug discoveries from the laboratory to patients -
October 07, 2026How a team of Case Western Reserve researchers is turning a decade of collaboration—and a portfolio of real-world innovations—into the future of precision medicine -
October 05, 2026Case Western Reserve researchers are rethinking the materials behind everyday life—and the new Interdisciplinary Science and Engineering Building is giving them the space to do it together.
A Place for Hands-on Learning
In the ISEB, research teams will develop groundbreaking solutions to challenges facing our climate, medical system, energy network and beyond—all supported by student researchers who will gain valuable hands-on experience.
Bringing a Vision to Life
Take a look at the architectural renderings of how the ISEB will transform Case Quad.
Exterior Quad Elevation
Exterior Quad Oblique
Exterior MLK Elevation
Exterior Gateway
Interior Grand Atrium Toward MLK
Interior Cafe Toward Stair
Interior Collaborative Space Oblique