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Aaron Burberry, PhD
Assistant ProfessorDepartment of PathologySchool of MedicineEmail: aaron.burberry@case.edu
Phone: 216.368.1066
Neurodegenerative diseases impart a devastating toll on patients and their caregivers, while costing hundreds of billions in lost wages and healthcare annually. Rare genetic mutations and common genetic polymorphisms interact in surprising ways with the environment to shape each person’s relative risk of developing disease. Our research leverages patient biomaterial, human pluripotent stem cells and animal models to discover disease relevant pathways to ultimately enable innovative therapeutic strategies.
William S. Bush, PhD
Associate Director for Computational GenomicsInstitute for Computational BiologyProfessorDepartment of Population and Quantitative Health SciencesSchool of MedicineAssociate ProfessorDepartment of Genetics and Genome SciencesSchool of MedicineEmail: wsb36@case.edu
Phone: 216.368.0411
I study bioinformatic and genomic analysis of complex diseases, such as late onset Alzheimer's Disease.
Ignazio Cali, PhD
Assistant ProfessorDepartment of PathologySchool of MedicineEmail: Ignazio.cali@case.edu
Phone: 216.368.4874
We are interested in determining the disease phenotypes and molecular features of co-existing protein aggregates in comorbid neurodegenerative disorders, including prion disease, Alzheimer’s disease (AD), and chronic traumatic encephalopathy. A major goal of these studies is to determine whether distinct prion strains modulate Aβ and tau neurodegeneration in cases with prion disease and AD. We are also examining the molecular properties of tau (including seeding properties) in individuals with prion disease and a history of traumatic brain injury. We employ sensitive diagnostic assays for the detection of minute amounts of pathogenic proteins (RT-QuIC) in addition to animal and cell models to understand the role of each pathogenic protein in multiproteinopathies.
Mark Cameron, PhD
Associate ProfessorDepartment of Population and Quantitative Health SciencesSchool of MedicineMemberCenter for RNA Science and TherapeuticsSchool of MedicineMemberImmune Oncology ProgramCase Comprehensive Cancer CenterFacultyCleveland Institute for Computational BiologyEmail: mjc230@case.edu
Phone: 216.368.3196
I investigate the role of interferon signaling genes and the inflammasome in regulating innate and adaptive immune responses in human emerging infectious disease and chronic illness, including COVID-19 research.
Cheryl Cameron, PhD
Assistant ProfessorDepartment of NutritionSchool of MedicineEmail: cheryl.cameron@case.edu
We are interested in using a systems immunology approach to study host response to viral infection (HIV, SARS-CoV, influenza), vaccination (SARS-CoV, influenza, varicella zoster virus), autoimmunity (psoriasis, psoriatic arthritis, POTS, Sjögren's syndrome), cardiovascular disease and cancer (melanoma, colorectal) in order to identify novel therapeutic targets and to inform personalized medicine.
David H. Canaday, MD
ProfessorDivision of Infectious Diseases & HIV MedicineSchool of MedicineEmail: dxc44@case.edu
Phone: 216.368.8901
My research is in the immunology of aging and vaccines with a focus on influenza and shingles vaccination. Specifically, I study COVID-19 in older populations and HIV/TB pathogensis.
Kaixiang Cao, PhD
Assistant ProfessorDepartment of BiochemistrySchool of MedicineMemberCancer Genomics and Epigenomics ProgramCase Comprehensive Cancer CenterAssistant ProfessorDepartment of Genetics and Genome SciencesSchool of MedicineEmail: kxc725@case.edu
Phone: 216.368.1218
Our lab is interested in understanding how epigenetic events, including histone modifications, DNA modifications, and nucleosome positioning, impact cell fate.
Cathleen R. Carlin, PhD
ProfessorDepartment of Molecular Biology and MicrobiologySchool of MedicineProfessorDepartment of Physiology and BiophysicsSchool of MedicineMemberMolecular Oncology ProgramCase Comprehensive Cancer CenterEmail: cxc39@case.edu
Phone: 216.368.8939
I study receptor tyrosine kinase signaling, human adenoviruses, and protein sorting.
Stephen Carpenter, MD, PhD
Assistant ProfessorDivision of Infectious Diseases & HIV MedicineDepartment of MedicineSchool of MedicineAssistant ProfessorDepartment of PathologySchool of MedicineEmail: sxc1507@case.edu
Phone: 216.368.4512
Our lab focuses on understanding protective memory T cell and macrophage responses to Mycobacterium tuberculosis and other chronic infectious diseases (e.g. CMV) using single-cell approaches including high-parameter FACS and scRNAseq.
Sudha Chakrapani, PhD
ChairDepartment of PharmacologyJohn H. Hord Professor and ChairSchool of MedicineDirectorCryo-Electron Microscopy CoreDirectorCleveland Center for Membrane & Structural BiologyEmail: sxc584@case.edu
Phone: 216.368.4631
My focus is in ion channel in fast synaptic neurotransmission, CryoEM methods, EPR spectroscopy, electrophysiology and X-ray crystallography.