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David Friel, PhD
Associate ProfessorDepartment of NeurosciencesSchool of MedicineEmail: david.friel@case.edu
Phone: 216.368.4930
I primarily focus on calcium homeostasis, electrophysiology, ion channels, modulation, optical methods for measuring Ca2+, and modeling.
Jeffrey L. Garvin, PhD
ProfessorDepartment of Physiology and BiophysicsEmail: jeffrey.garvin@case.edu
Phone: 216.368.3353
My research areas include regulation of renal ion transport, hemodynamics and cell signaling, and their roles in blood pressure control. In particular we are now investigating how dietary fructose changes kidney metabolism and thuis ion trasport in the proximal nephron and how the mechanical stimulus of urine flow is transduced into chemical signals that ultimately alter Na reabsorption in thick ascending limbs.
Leah A. Gates, PhD
Assistant ProfessorDepartment of BiochemistrySchool of MedicineMemberCancer Genomics and Epigenomics ProgramCase Comprehensive Cancer CenterEmail: leah.gates@case.edu
Phone: 216-368-5572
We study the intersection between metabolism, chromatin, and gene regulation. We aim to discover how metabolite signaling to chromatin impacts cell and tissue function in health and disease, with a particular focus on the intestine. We use biochemical techniques, cell culture and organoid systems, and animal models to carry out our research.
Thomas A. Gerken , PhD
ProfessorDepartment of BiochemistrySchool of MedicineProfessorDepartment of PediatricsSchool of MedicineMemberPopulation and Cancer Prevention ProgramCase Comprehensive Cancer CenterEmail: thomas.gerken@case.edu
Phone: 216.368.4556
Mucin type O-glycosylation is an essential post translational protein modification linked to multiple disease states including many cancers and is critical to development. Our lab studies the control of mucin type O-glycosylation at the transferase and peptide acceptor substrate level. We utilize enzyme activity/kinetics and structural biological approaches to deduce how the initiating glycosyltransferases select and recognize specific sites to glycosylate in protein substrates.
Stanton L. Gerson, MD
DeanSchool of MedicineSenior Vice President for Medical AffairsDirectorNational Center for Regenerative MedicineProfessorDepartment of MedicineProfessorDepartment of Environmental Health SciencesMemberImmune Oncology ProgramCase Comprehensive Cancer CenterEmail: stanton.gerson@case.edu
Phone: 216.368.2825
We investigate transgenic mice and carcinogenesis, retroviral gene therapy, DNA repair, hematopoietic stem cells, and adipogenesis.
Mahmoud Ghannoum, PhD
ProfessorDepartment of DermatologySchool of MedicineProfessorDepartment of PathologySchool of MedicineMemberMolecular Oncology ProgramCase Comprehensive Cancer CenterEmail: mahmoud.ghannoum@case.edu
Phone: 216.844.8580
My lab investigates fungal pathogens including Candida, Aspergillus and Cryptococcus, in addition to fungal virulence factors including phospholipase B, germination, adhesion, and biofilm formation.
Marcin Golczak, PhD
Associate ProfessorDepartment of PharmacologySchool of MedicineMemberCleveland Center for Membrane & Structural BiologyEmail: mxg149@case.edu
Phone: 216.368.0302
I research the physiology of vision at the molecular level and lipid metabolism and homeostasis in the eye. I also design therapeutic strategies against age-related retinal degeneration and dry eye syndrome.
Wendy A. Goodman, PhD
Assistant ProfessorDepartment of PathologySchool of MedicineEmail: wag@case.edu
Phone: 216.368.3920
We are interested in mechanisms by which endocrine hormones influence the immune response. Receptors for steroid hormones (estrogens, androgens, and progesterone) are broadly expressed and regulate gene transcription in target cells. We study how these pathways operate in immune cells, particularly how they contribute to the balance between immune homeostasis and chronic inflammation & autoimmunity.
Berkley Gryder, PhD
Assistant ProfessorDepartment of Genetics and Genome SciencesSchool of MedicineAssistant ProfessorCase Comprehensive Cancer CenterSchool of MedicineMemberCancer Genomics and Epigenomics ProgramCase Comprehensive Cancer CenterMemberAngie Fowler Adolescent and Young Adult Cancer Research InitiativeEmail: berkley.gryder@case.edu
Phone: 216.368.8749
The Gryder lab studies how transcription is controlled by the 3D folding of the epigenome, through the lens of 3D chromatin sequencing techniques and biomolecular condensates. We are especially interested in using these approaches to understand the mechanism of action for new anti-cancer therapies that target proteins involved in regulating chromatin (transcription factors, epigenetic machinery). The diseases we work on most include childhood sarcomas and advanced forms of prostate cancer.
Sanjay Gupta, PhD, MS
Carter Kissell Professor and Research DirectorDepartment of UrologySchool of MedicineAssociate ProfessorDepartment of NutritionSchool of MedicineMemberPopulation and Cancer Prevention ProgramCase Comprehensive Cancer CenterEmail: sanjay.gupta@case.edu
Phone: 216.368.6162
I research biomarkers for early detection and prognosis of prostate cancer, molecular targets for prevention and treatment of prostate cancer, and epigenetic mechanisms of gene silencing.