The main interest in my laboratory revolves around the elucidation principles of eye physiology at the molecular level, discerning mechanisms of their regulation, and pathophysiological consequences of their malfunction for ocular health. Based on this knowledge, our goal is to design, test, and validate, new therapeutic strategies against prevalent eye disorders, including age-related retinal degeneration or dry eye syndrome.
Over the last several years, we have performed productive research focused on understanding biochemical principles governing lipid metabolism in the eye. We have contributed substantially to understanding the mechanistic principles of ocular retinoid metabolism, regeneration of the visual chromophore, and the production of unique lipids involved in forming the protective tear film. Based on our education and training, we have successfully combined methods of organic and protein chemistry, structural biology, and modern instrumental analytical techniques with in vivo studies to elucidate fundamental processes responsible for maintaining eye health as well as predicted pathophysiological consequences of their malfunction. Building upon these basic discoveries, we developed and tested novel pharmacological strategies for the treatment of progressive retinal diseases and dry eye syndrome. This experience encouraged us to look for new promising pharmacological targets and spearhead innovative projects that aim at developing methods of preventing and preserving ocular health.