Dr. Chance is an internationally recognized expert in proteomics and structural biology who has built multiple internationally recognized science and training programs over a 30-year career in academia. He has published over 300 papers with over 18,000 citations with an H-index of 72 (Google scholar). He is currently Vice Dean for Research and holds the title of Distinguished University Professor and Professor appointments in the Departments of Nutrition, Genetics & Genome Sciences, and General Medical Sciences at the School of Medicine of Case Western Reserve University (CWRU). At CWRU, he directs the Center for Proteomics and Bioinformatics, the Center for Synchrotron Biosciences, and the Systems Biology Graduate Program. He is also holder of the Charles W. and Iona A. Mathias Chair in Cancer Research. Dr. Chance has led dozens of Federally funded research projects over his career is a member of many national and international advisory panels in a wide range of research and training areas. He has multiple patents and patent filings and has launched a successful startup company, NeoProteomics, Inc.
My research is in proteomics and systems biology in cancer and Alzheimer's Disease. I also study proten-protein and protein-small molecule interactions and sensing via integrative biophysics, as well as structural mass spectrometry and protein crystallography.
Teaching Information
Teaching Interests
- Systems biology
- Proteomics
Courses Taught
Office Hours
MW 9-3
Research Information
Research Projects
- Co-phosphorylation as a predictor of biological functions
- Biosensor Development for stress sensing
- Multiplex chemistry labeling to extend protein footprinting
Recent Funding
Title: Clinical and Translational Science Collaborative
Project Number: UL1- TR-002548
Name of PD/PI: Michael Konstan
Source of Support: NCATS/NIH
Role on Project: PI of Translational Endeavors Core and Associate PI of grant
Project/Proposal Start and End Date: 09/2007 – 05/2023
Title: Case Comprehensive Cancer Center
Project Number: P30-CA-043703
Name of PD/PI: Stan Gerson
Source of Support: NCI/NIH
Role on Project: PI of Proteomics Core Project/Proposal
Start and End Date: 07/2007 – 06/2023
Title: Construction, Analysis, and Utilization of Co-Phosphorylation Networks to Characterize Cellular Signaling
Project Number: R01-LM-012980 and R01-LM-012980-S1
Name of PD/PI: Mehmet Koyuturk
Source of Support: NLM/NIH
Role on Project: Co-I
Project/Proposal Start and End Date: 07/2019 – 03/2023
Title: Case Center for Biomolecular Structure and Integration for Sensors
Project Number: NB18-20-24
Name of PD/PI: Mark Chance
Source of Support: Nano-Bio Materials Consortium/ Air Force
Project/Proposal Start and End Date: 07/2020 – 06/2024
Title: Multiplex Labeling Chemistry Methods for Protein Footprinting
Project Number: R01-GM-141078
Name of PD/PI: Janna Kiselar
*Source of Support: NIGMS/NIH Role on Project: Co-I
Project/Proposal Start and End Date: 05/2021 – 03/2025