A
bipolar nerve cuff electrode has two
contacts for current flow. One contact, the 'cathode',
depolarizes
the membrane (towards more positive potentials), where
the Action Potential(AP) is generated. The other, an 'anode'
injects current and hyperpolarizes the axon membrane potential
(towards more negative potentials) and can arrest AP propagation.
Because current flows in all directions, pathways at the
open end of the nerve cuff form 'virtual' contacts that
act on the axons. A 'virtual cathode' outside the 'anodic'
end of the electrode, and a 'virtual anode' outside the
'cathodic' end. APs may be generated at this 'virtual cathode'
when the current flow at this location causes threshold
depolarization.
In a tripolar cuff electrode, a central
'cathode' is flanked by a pair of 'anodes'. The total current
to the 'cathode'
is divided between these two 'anodic' contacts. Since there
is current flowing to both anodes, the potential at each
end is similar and there is a reduced tendency for current
to flow outside the cuff. This ensures that most of the
current is contained within the insulating walls of the
electrode, limiting the formation of 'virtual' cathodes
outside the two 'anodic' ends of the cuff. By distributing
the currents unequally to the two anodes, one of them can
arrest the 'cathode' initiated APs coming to it and the
other can suppress the tendency for a virtual cathode to
develop outside the arresting end yet allow the evoled
AP to 'escape' and propagate at the other end, called the
escape end.