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Jeffrey L. Garvin, PhD
Professor, Department of Physiology and BiophysicsEmail: jeffrey.garvin@case.edu
Phone: 216.368.3353
My research areas include regulation of renal ion transport, hemodynamics and cell signaling, and their roles in blood pressure control. In particular we are now investigating how dietary fructose changes kidney metabolism and thuis ion trasport in the proximal nephron and how the mechanical stimulus of urine flow is transduced into chemical signals that ultimately alter Na reabsorption in thick ascending limbs.
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Leah A. Gates, PhD
Assistant Professor, Department of Biochemistry, School of MedicineMember, Cancer Genomics and Epigenomics Program, Case Comprehensive Cancer CenterEmail: leah.gates@case.edu
Phone: 216-368-5572
We study the intersection between metabolism, chromatin, and gene regulation. We aim to discover how metabolite signaling to chromatin impacts cell and tissue function in health and disease, with a particular focus on the intestine. We use biochemical techniques, cell culture and organoid systems, and animal models to carry out our research.
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Thomas A. Gerken , PhD
Professor, Department of Biochemistry, School of MedicineProfessor, Department of Pediatrics, School of MedicineMember, Population and Cancer Prevention Program, Case Comprehensive Cancer CenterEmail: thomas.gerken@case.edu
Phone: 216.368.4556
Mucin type O-glycosylation is an essential post translational protein modification linked to multiple disease states including many cancers and is critical to development. Our lab studies the control of mucin type O-glycosylation at the transferase and peptide acceptor substrate level. We utilize enzyme activity/kinetics and structural biological approaches to deduce how the initiating glycosyltransferases select and recognize specific sites to glycosylate in protein substrates.
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Stanton L. Gerson, MD
Dean, School of MedicineSenior Vice President for Medical AffairsDirector, National Center for Regenerative MedicineProfessor, Department of MedicineProfessor, Department of Environmental Health SciencesMember, Immune Oncology Program, Case Comprehensive Cancer CenterEmail: stanton.gerson@case.edu
Phone: 216.368.2825
We investigate transgenic mice and carcinogenesis, retroviral gene therapy, DNA repair, hematopoietic stem cells, and adipogenesis.
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Mahmoud Ghannoum, PhD
Professor, Department of Dermatology, School of MedicineProfessor, Department of Pathology, School of MedicineMember, Molecular Oncology Program, Case Comprehensive Cancer CenterEmail: mahmoud.ghannoum@case.edu
Phone: 216.844.8580
My lab investigates fungal pathogens including Candida, Aspergillus and Cryptococcus, in addition to fungal virulence factors including phospholipase B, germination, adhesion, and biofilm formation.
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Marcin Golczak, PhD
Associate Professor, Department of Pharmacology, School of MedicineMember, Cleveland Center for Membrane & Structural BiologyEmail: mxg149@case.edu
Phone: 216.368.0302
I research the physiology of vision at the molecular level and lipid metabolism and homeostasis in the eye. I also design therapeutic strategies against age-related retinal degeneration and dry eye syndrome.
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Wendy A. Goodman, PhD
Assistant Professor, Department of Pathology, School of MedicineMember, Immune Oncology Program, Case Comprehensive Cancer CenterEmail: wag@case.edu
Phone: 216.368.3920
We are interested in mechanisms by which endocrine hormones influence the immune response. Receptors for steroid hormones (estrogens, androgens, and progesterone) are broadly expressed and regulate gene transcription in target cells. We study how these pathways operate in immune cells, particularly how they contribute to the balance between immune homeostasis and chronic inflammation & autoimmunity.
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Berkley Gryder, PhD
Assistant Professor, Department of Genetics and Genome Sciences, School of MedicineAssistant Professor, Case Comprehensive Cancer Center, School of MedicineMember, Cancer Genomics and Epigenomics Program, Case Comprehensive Cancer CenterMember, Angie Fowler Adolescent and Young Adult Cancer Research InitiativeEmail: beg33@case.edu
Phone: 216.368.8749
The massively complex human genome is a super-computer that carefully controls its information. It uses chemical-genetic circuits, 3D folding, and signal integration to maintain cell identity and all biological functions. Our lab is excited to unravel the principles of the super-computer we call the epigenome, and do so in the context of cancer.
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Sanjay Gupta, PhD, MS
Carter Kissell Professor and Research Director, Department of Urology, School of MedicineAssociate Professor, Department of Nutrition, School of MedicineMember, Population and Cancer Prevention Program, Case Comprehensive Cancer CenterEmail: sanjay.gupta@case.edu
Phone: 216.368.6162
I research biomarkers for early detection and prognosis of prostate cancer, molecular targets for prevention and treatment of prostate cancer, and epigenetic mechanisms of gene silencing.
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Neetu Gupta, PhD
Associate Professor, Department of Molecular Medicine, School of MedicineMember, Immune Oncology Program, Case Comprehensive Cancer CenterEmail: guptan@ccf.org
Phone: 216.444.7455
I focus on molecular mechanisms regulating antibody-mediated immunity to infections and B cell lymphoma pathogenesis.