Mark Chance, PhD

Department of Nutrition
School of Medicine
Center for Proteomics and Bioinformatics
School of Medicine
Charles W. and Iona A. Mathias Professor of Cancer Research
School of Medicine
Department of Genetics and Genome Sciences
School of Medicine
Developmental Therapeutics Program
Case Comprehensive Cancer Center
Cleveland Center for Membrane & Structural Biology

Dr. Chance is an internationally recognized expert in proteomics and structural biology who has built multiple internationally recognized science and training programs over a 30-year career in academia. He has published over 300 papers with over 18,000 citations with an H-index of 72 (Google scholar). He currently holds the title of Distinguished University Professor and Professor appointments in the Departments of Nutrition, Genetics & Genome Sciences, and General Medical Sciences at the School of Medicine of Case Western Reserve University (CWRU). At CWRU, he directs the Center for Proteomics and Bioinformatics, the Center for Synchrotron Biosciences, and the Systems Biology Graduate Program. He is also holder of the Charles W. and Iona A. Mathias Chair in Cancer Research. Dr. Chance has led dozens of Federally funded research projects over his career is a member of many national and international advisory panels in a wide range of research and training areas. He has multiple patents and patent filings and has launched a successful startup company, NeoProteomics, Inc.

View Dr. Chance's Biosketch

Teaching Information

Teaching Interests

  • Systems biology
  • Proteomics

Courses Taught

SYBB 555. Current Proteomics

Office Hours

MW 9-3

Research Information

Research Projects

  • Co-phosphorylation as a predictor of biological functions
  • Biosensor Development for stress sensing
  • Multiplex chemistry labeling to extend protein footprinting

Recent Funding

Title: Clinical and Translational Science Collaborative
Project Number: UL1- TR-002548
Name of PD/PI: Michael Konstan
Source of Support: NCATS/NIH
Role on Project: PI of Translational Endeavors Core and Associate PI of grant
Project/Proposal Start and End Date: 09/2007 – 05/2023

Title: Case Comprehensive Cancer Center
Project Number: P30-CA-043703
Name of PD/PI: Stan Gerson
Source of Support: NCI/NIH
Role on Project: PI of Proteomics Core Project/Proposal
Start and End Date: 07/2007 – 06/2023

Title: Construction, Analysis, and Utilization of Co-Phosphorylation Networks to Characterize Cellular Signaling
Project Number: R01-LM-012980 and R01-LM-012980-S1
Name of PD/PI: Mehmet Koyuturk
Source of Support: NLM/NIH
Role on Project: Co-I
Project/Proposal Start and End Date: 07/2019 – 03/2023

Title: Case Center for Biomolecular Structure and Integration for Sensors
Project Number: NB18-20-24
Name of PD/PI: Mark Chance
Source of Support: Nano-Bio Materials Consortium/ Air Force
Project/Proposal Start and End Date: 07/2020 – 06/2024

Title: Multiplex Labeling Chemistry Methods for Protein Footprinting
Project Number: R01-GM-141078
Name of PD/PI: Janna Kiselar
*Source of Support: NIGMS/NIH Role on Project: Co-I
Project/Proposal Start and End Date: 05/2021 – 03/2025

Awards and Honors

Naomi Kanof Investigator Award Lectureship and Medal for Distinguished Achievement in Clinical Investigation
Society of Investigative Dermatology
Charles W. and Iona A. Mathias Chair in Cancer Research
Case Western Reserve University
Fellow in the Field of Chemistry
American Association for the Advancement of Science
Research Sharing Award (2nd place)
American Association of Medical Colleges
Distinguished University Professor
Case Western Reserve University

External Appointments

Chief Science Officer
Neo Proteomics
Scientific Advisory Board
GenNext Technologies, Inc.
Advisory Committee
National Prion Disease Pathology Surveillance Center, CWRU



Doctor of Philosophy
University of Pennsylvania

Residencies, Internships and Fellowships

Postdoctoral Associate, Department of Electromagnetic Phenomena
AT&T Bell Laboratories