Postdoctoral Scholars

 

Vidya Gopakumar, Ph.D.

Von Lintig Lab

vxg255@case.edu


Sora Jin, Ph.D. 

Zhang lab

sxj572@case.edu

 

Sapanlika Swarnamali Baththana Madiyanselage, Ph.D. 

Von Lintig lab

sxb1081@case.edu 


Rakesh Maharjan, Ph.D.

Yu lab

rxm785@case.edu


Suraj Kumar Mandal, Ph. D. 

Yu Lab

skm138@case.edu


Mitchell Moseng, Ph.D. 

Yu lab 

mam535@case.edu 

 


Wilnelly M. Hernandez-Sanchez headshot
Wilnelly Hernandez-Sanchez, Ph.D. 

Taylor lab

wmh31@case.edu


Nicole Wagner, Ph.D.

Stewart Lab

nxw243@case.edu


Anna Walczak-Szeffer, Ph.D. 

Golczak Lab

adw116@case.edu


Fangfang Wang, Ph.D.

Zhang Lab

fxw188@case.edu


Zhemin
Zhemin Zhang, Ph.D. 

Yu lab 

zxz964@case.edu

Research Summary: 

Acinetobacter baumannii is a Gram-negative, nonfermentative bacillus, which is considered as an important nosocomial pathogen causing pneumonia, urinary tract infections, bacteremia, septicemia, and meningitis. Infected by A. baumannii is extremely difficult to cure. One major mechanism that A. baumannii uses to mediate antibiotic resistance is the expression of multidrug efflux pumps, especially those belonging to the resistance-nodulation-cell division (RND) superfamily. The most clinically relevant RND-type multidrug efflux in A. baumannii is the AdeJ membrane protein, which extrudes multiple classes of antibiotics, such as tetracyclines, aminoglycosides, β-lactams, and fluoroquinolones. However, the substrate recognition mechanism of AdeJ is still unknown. Thus, an atomic level structure of A. baumannii AdeJ multidrug efflux pump bound with substrate complex will be the key point to reveal a mechanism on how AdeJ recognize and extrude the antibiotics. These data in the project will provide an essential structural foundation for future anti-bacterial drug discovery.