Chih-Chia (Jack) Su, PhD

Assistant Professor
Department of Pharmacology
School of Medicine

Dr. Su received his Ph.D. in the Department of Biochemistry, Biophysics, and Molecular Biology at Iowa State University, where he performed structural and functional studies of multidrug efflux systems in bacteria. As a postdoctoral researcher, he extended his research on bacterial multidrug resistance, quickly being promoted to assistant then associate scientist. This research work resulted in several publications in high impact journals such as Nature, Nature Communications, and PNAS.  He joined Case Western Reserve University as an Instructor and is currently an Assistant Professor in the Department of Pharmacology. His independent research focuses on structural and functional insights into outer membrane asymmetry in Gram-negative bacteria and host-pathogen interactions. As a trained structural biologist, he utilizes single particle cryo-electron microscopy (cryo-EM) and has recently developed the "Build and Retrieve" (BaR) methodology to simultaneously characterize multiple macromolecular complex structures directly from cells, tissue, and organs


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Selected Publications
1. High-resolution structural-omics of human liver enzymes. Su CC, Lyu M, Zhang Z, Miyagi M, Huang W, Taylor DJ, Yu EW. Cell Rep. 2023 Jun 27;42(6):112609. doi: 10.1016/j.celrep.2023.112609. Epub 2023 Jun 7. PMID: 37289586. PMCID: PMC10592444.

2. Structures of the mycobacterial membrane protein MmpL3 reveal its mechanism of lipid transport. Su CC, Klenotic PA, Cui M, Lyu M, Morgan CE, Yu EW. PLoS Biol. 2021 Aug 12;19(8):e3001370. doi: 10.1371/journal.pbio.3001370. eCollection 2021 Aug. PMID: 34383749. PMCID: PMC8384468.

3. Structural basis of transport and inhibition of the Plasmodium falciparum transporter PfFNT. Lyu M, Su CC, Kazura JW, Yu EW. EMBO Rep. 2021 Aug 4;22(8):e53447. doi: 10.15252/embr.202153447. PMID: 34350707. PMCID: PMC8339692.

4. A 'Build and Retrieve' methodology to simultaneously solve cryo-EM structures of membrane proteins. Su CC, Lyu M, Morgan CE, Bolla JR, Robinson CV, Yu EW. Nat Methods. 2021 Jan;18(1):69-75. doi: 10.1038/s41592-020-01021-2. Epub 2021 Jan 6. PMID: 33408407. PMCID: PMC7808410.

5. MmpL3 is a lipid transporter that binds trehalose monomycolate and phosphatidylethanolamine. Su CC, Klenotic PA, Bolla JR, Purdy GE, Robinson CV, Yu EW. Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11241-11246. doi: 10.1073/pnas.1901346116. Epub 2019 May 21. PMID: 31113875. PMCID: PMC6561238.