Research in our lab centers on the chemistry and biology of lipids. Our central interests revolve around the identification of novel small molecules, and careful investigations into the chemistry and physiology of known molecules. From a training point of view, our work spans from pure synthetic organic chemistry to animal biology in disease models, and students in the laboratory have projects involving: target oriented synthesis, diversity oriented synthesis, protein biochemistry, metabolomics, and cell signaling. Our laboratory specializes in organic synthesis and protein biochemistry and we have developed strong collaborative relationships with other research groups at CWRU School of Medicine, and the Cleveland Clinic.
We are generally interested in two physiologic processes that are primarily driven by an exquisite network of small molecules:
- The Linkage Between Oxidative Stress Pathways and Lipid Peroxidation
- The Role of the Fatty Acid Binding Protein Family in Lipid Signaling
- Barker EC, Gatbonton-Schwager TN, Han Y, Clay, JE, Letterio JJ, Tochtrop GP*. Bryonolic Acid: A Large-Scale Isolation and Evaluation of Heme Oxygenase 1 Expression in Activated Macrophages. J. Nat. Prod. 2010, 73, 1064-1068.
- Sadhukhan S, Han Y, Zhang G, Brunengraber H, Tochtrop GP*. Using Isotopic Tools to Dissect and Quantitate Parallel Metabolic Pathways. J. Am. Chem. Soc. 2010, 132, 6309-6311.
- Zhang G, Kombu RS, Kasumov T, Han Y, Sadhukhan S, Zhang J, Sayre L, Ray D, Gibson KM, Anderson VA, Tochtrop GP, Brunengraber H. Catabolism of 4-Hydroxyacids and 4-Hydroxynonenal via 4-Hydroxy-4-phosphoacyl-CoAs. J. Biol. Chem. 2009; 284, 33521. Highlighted as paper of the week for Nov 27th 2009.