Zhemin Zhang, PhD

Assistant Professor
Department of Pharmacology
School of Medicine

Dr. Zhang’s research is dedicated to uncovering the functional mechanisms of key disease-related proteins using structural biology and other biophysical techniques. He aims to leverage this knowledge to develop novel therapeutics for diseases where there are minimal or no effective treatments. His training is extensive and varied, encompassing a wide range of computational and experimental techniques, such as virtual screening, protein-ligand docking, X-ray crystallography and cryo-electron microscopy. He earned his Ph.D. from the School of Life Science at Sun Yat-sen University in China, where he focused on studying the structural basis and function of microbial nucleic acid repair enzymes. Following this, he joined the Department of Pharmacology at Case Western Reserve University as a postdoctoral researcher in 2019. During this time, he aimed to understand the structure/function of proteins associated with drug resistance in pathogenic microorganisms. Currently serving as an assistant professor, his independent research primarily focuses on elucidating the structure of proteins in mammalian tissues through the lens of structural proteomics.


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  1. Zhang Z#, Tringides ML#, Morgan CE, Miyagi M, Mears JA, Hoppel CL, Yu EW. High-Resolution Structural Proteomics of Mitochondria Using the 'Build and Retrieve' Methodology. Mol Cell Proteomics. 2023 Dec;22(12):100666. doi: 10.1016/j.mcpro.2023.100666. Epub 2023 Oct 14. PubMed PMID: 37839702; PubMed Central PMCID: PMC10709515.
  2. Zhang Z, Lizer N, Wu Z, Morgan CE, Yan Y, Zhang Q, Yu EW. Cryo-Electron Microscopy Structures of a Campylobacter Multidrug Efflux Pump Reveal a Novel Mechanism of Drug Recognition and Resistance. Microbiol Spectr. 2023 Aug 17;11(4):e0119723. doi: 10.1128/spectrum.01197-23. Epub 2023 Jun 8. PubMed PMID: 37289051; PubMed Central PMCID: PMC10434076.
  3. Su CC#, Lyu M#, Zhang Z#, Miyagi M, Huang W, Taylor DJ, Yu EW. High-resolution structural-omics of human liver enzymes. Cell Rep. 2023 Jun 27;42(6):112609. doi: 10.1016/j.celrep.2023.112609. Epub 2023 Jun 7. PubMed PMID: 37289586; PubMed Central PMCID: PMC10592444.
  4. Zhang Z, Morgan CE, Cui M, Yu EW. Cryo-EM Structures of AcrD Illuminate a Mechanism for Capturing Aminoglycosides from Its Central Cavity. mBio. 2023 Feb 28;14(1):e0338322. doi: 10.1128/mbio.03383-22. Epub 2023 Jan 10. PubMed PMID: 36625574; PubMed Central PMCID: PMC9973356.
  5. Morgan CE#, Zhang Z#, Miyagi M, Golczak M, Yu EW. Toward structural-omics of the bovine retinal pigment epithelium. Cell Rep. 2022 Dec 27;41(13):111876. doi: 10.1016/j.celrep.2022.111876. PubMed PMID: 36577381; PubMed Central PMCID: PMC9875382.