Trainers Directory

My research focuses on molecular mechanisms regulating genome stability and their potential application in cancer therapy.

Youwei Zhang's Biography 

Our laboratory combines molecular, cellular, and electrophysiological approaches with state-of-art Expansion Microscopy and 3D electron microscopy in the cultured neuron and transgenic mouse models to analyze how neurons establish their communications through a specialized unit termed “synapse”. We are particularly interested in an interdisciplinary study about the role of extracellular polysaccharide in regulating the structure and function of synapses. Elucidating these mechanisms is important for understanding how synapses develop in health and how they dysfunction in neurodevelopmental and neurodegenerative disorders.

Peng Zhang's Biography 

We are focusing on seeking in-depth understanding of the mechanisms of hematopoietic stem/progenitor cell (HSPC) self-renewal, the interactions of HSPCs and bone marrow microenvironment, and how these become dysregulated to cause leukemia/lymphoma. Specifically, we are focusing on 1) How HSF1 specifically regulates AML stem cells; and 2) how B-myeloid conversion is regulated in a pathological context.

Chen Zhao's Biography

I research the genes and molecular pathways involved in mouse models of human deafness, including Otitis Media and Usher syndrome.

My labs studies Notch signaling in stress hematopoiesis, hematopoietic stem cell niche, and leukemia microenvironment. Additional projects include pathogenesis of inflammation-associated colorectal cancer mouse models and targeting pancreatic cancer metabolic vulnerability and drug resistance.

Lan Zhou's Biography 

My lab studies pathogenic mechanisms underlying neurodegeneration in age-related neurodegenerative diseases including Alzheimer's disease and Parkinson disease with a focus on mitochondrial dysfunction and oxidative stress. A variety of experimental systems are used, including primary and transformed neuronal cells and multiple mouse models representing these disorders as well as brain tissues from human patients.

Xiongwei Zhu's Biography 

We are interested in developing statistical methods and software in genetic association analysis controlling population stratification and rare variants association analysis using omics data. We are also interested in developing admixture mapping methods and software in disease mapping using recent admixed population data. We also utilize statistical methods and bioinformatic tools to identify genes associated with disease phenotypes, including hypertension, cardiovascular disease, obesity and sleep apnea.

Xiaofeng Zhu's Biography

We are interested in utilizing an advancing imaging technique, cryo-electron tomography, to visualize antimicrobial protein complexes directly in their native cellular context. We also employ cryo-EM single particle analysis and other biophysical techniques to study the structure and mechanism of antimicrobial macromolecular complexes. We aim to provide essential structural information to help develop strategies to combat infectious diseases.

Shiwei Zhu's Biography 

I focus on changes in neuronal gene expression after injury and their relationship to nerve regeneration. I study the role of immune cells in nerve degeneration and regeneration, and compare nerve regeneration in different types of sensory neurons. 

Richard Zigmond's Biography