Jacob Witten graduated from Amherst College with degrees in Biophysics and Mathematics and obtained his Ph.D. in Computational & Systems Biology at MIT under advisor Dr. Katharina Ribbeck. He completed his postdoctoral studies with Dr. Daniel Anderson in the Koch Institute for Integrative Cancer Research at MIT. There, he used a combination of deep learning and novel experimental platforms to identify lipid nanoparticles with improved mRNA and DNA delivery throughout the body, notably including state-of-the-art airway delivery. Jacob joined the Genetics department in 2026 and will be continuing to research gene therapy.
Research Information
Research Interests
A vast array of diseases could be cured or prevented by safely getting the right genes into the right cells. Unfortunately, in the vast majority of cases, we lack this capability due to significant biological
Publications
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Selected Publications
Witten, J.*, Manan, R.*, Raji, I.*, Beyer, E., Bartlett, S., Tang, Y., Ebadi, M., Lei, J., Nguyen, D., Oladimeji, F., Jiang, A., MacDonald, E., Hu, Y., Mughal, H., Self, A., Collins, E., Yan, Z., Engelhardt, J.F., Langer, R., Anderson, D.G. (2024). Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy. Nature Biotechnology, doi: https://doi.org/10.1038/
Witten, J.*, Jiang, A*, Raji, I.*, Eweje, F., MacIsaac, C., Oladimeji, F., Langer, R., Anderson, D. (2023). Combinatorial development of nebulized mRNA delivery formulations for the lungs. Nature Nanotechnology, 1-12.
*Co-first authors