Dr. Crawford’s laboratory accesses large-scale epidemiologic and clinical data to characterize common and rare genetic variants associated with human diseases. A particular interest is in identifying pleiotropy (when a single gene or variant influences two or more seemingly unrelated traits) and environmental modifiers of genetic associations, including pharmacogenomics (the study of how genetic variants affect a person's response to drugs). She has played leading roles in NIH-funded consortia dedicated to developing the infrastructure for national studies emphasizing diversity and drawing from electronic health records integrated with genomics. Dr. Crawford promotes the cultivation of women and minorities in STEM education and research, recognizing that perspectives and findings from diverse studies can unlock why people with diverse genetic, behavioral, and environmental backgrounds can have varied risks for diseases and outcomes to interventions or treatments.
Contributions to science:
- Generalization of GWAS-identified variants in diverse populations, notably applied to the Epidemiologic Architecture for Genes Linked to Environment (EAGLE) study, a site of the larger NHGRI-funded PAGE I study
- Identification of environmental and genetic modifiers relevant to human complex phenotypes, using traditional and emerging statistical approaches
- Use of biorepositories linked to electronic health records for genomic studies, which involves developing strategies for electronic phenotyping EHR data
- Identification and characterization of pleiotropy amongst nuclear and mitochondrial variants in diverse populations
Dr. Crawford’s laboratory accesses large-scale epidemiologic and clinical data in electronic health records to characterize common and rare genetic variants associated with human diseases. A particular interest is in identifying pleiotropy (when a single gene influences two or more seemingly unrelated physical traits) and environmental modifiers of genetic associations, including pharmacogenomics (the study of how genes affect a person’s response to drugs). She has published more than 160 peer-reviewed manuscripts.
Among her accomplishments was serving as principal investigator of the NIH’s Electronic Medical Records & Genomics (eMERGE) Network Coordinating Center and co-chair of the eMERGE Network’s Genomics Working Group. She also played a leadership role in the NIH’s Population Architecture using Genomics and Epidemiology (PAGE) study. She is currently serving a three-year term as an elected member of the American Society of Human Genetics Board of Directors.
In addition to her primary research, Dr. Crawford promotes the cultivation of women and minorities in STEM education and research by organizing and participating in national and international workshops and educational lectures, that emphasize participation and perspectives or women and minorities. She is an advocate for diversity in research design and cohort recruitment, recognizing that perspectives and findings from diverse studies can unlock why people with diverse genetic, behavioral, and environmental backgrounds can have varied outcomes to interventions or treatments.
Her honors and awards include the Case Western Reserve University School of Medicine Faculty Diversity Award, Society for Advancement of Chicanos and Native Americans in Science Distinguished Research Mentor Award, Kavli Frontiers of Science Fellow, Keystone Symposia on Molecular and Cellular Biology Fellow, NCMHD/NIH Health Disparities Research Scholar, and the ASHG C.W. Cotterman Award.
Before coming to CWRU, Dr. Crawford spent eight years as tenure-track faculty in the Department of Molecular Physiology and Biophysics and Investigator in the Center for Human Genetics Research at Vanderbilt University.
- Pendergrass, SA, Buyske, S, Jeff, JM, Frase, A, Dudek, S, Bradford, Y, Ambite, JL, Avery, CL, Buzkova, P, Deelman, E, Fesinmeyer, MD, Haiman, C, Heiss, G, Hindorff, LA, Hsu, CN, Jackson, RD, Lin, Y, Le Marchand, L, Matise, TC, Monroe, KR, Moreland, L, North, KE, Park, SL, Reiner, A, Wallace, R, Wilkens, LR, Kooperberg, C, Ritchie, MD, Crawford, DC. A phenome-wide association study (PheWAS) in the Population Architecture using Genomics and Epidemiology (PAGE) study reveals potential pleiotropy in African Americans. PLoS ONE 2019; 14 (12): e0226771. PubMed PMID:31891604 PubMed Central PMC6938343.
- Crawford, DC, Lin, J, Cooke Bailey, JN, Kinzy, T, Sedor, JR, O'Toole, JF, Bush, WS. Frequency of ClinVar Pathogenic Variants in Chronic Kidney Disease Patients Surveyed for Return of Research Results at a Cleveland Public Hospital. Pac Symp Biocomput 2020; 25 : 575-586. PubMed PMID:31797629 PubMed Central PMC6931908.
- Bush, WS, Cooke Bailey, JN, Beno, MF, Crawford, DC. Bridging the Gaps in Personalized Medicine Value Assessment: A Review of the Need for Outcome Metrics across Stakeholders and Scientific Disciplines. Public Health Genomics 2019; 22 (1-2): 16-24. PubMed PMID:31454805 PubMed Central PMC6752968.
- Halladay, CW, Hadi, T, Anger, MD, Greenberg, PB, Sullivan, JM, Konicki, PE, Peachey, NS, Igo, RP Jr, Iyengar, SK, Wu, WC, Crawford, DC, VA Million Veteran Program. Genetically-guided algorithm development and sample size optimization for age-related macular degeneration cases and controls in electronic health records from the VA Million Veteran Program. AMIA Jt Summits Transl Sci Proc 2019; 2019 : 153-162. PubMed PMID:31258967 PubMed Central PMC6568141.
- Crawford, DC, Cooke Bailey, JN, Briggs, FBS. Mind the gap: resources required to receive, process and interpret research-returned whole genome data. Hum. Genet. 2019; 138 (7): 691-701. PubMed PMID:31161416 PubMed Central PMC6767905.
- Hollister, BM, Farber-Eger, E, Aldrich, MC, Crawford, DC. A Social Determinant of Health May Modify Genetic Associations for Blood Pressure: Evidence From a SNP by Education Interaction in an African American Population. Front Genet 2019; 10 : 428. PubMed PMID:31134134 PubMed Central PMC6523518.
- Pendergrass, SA, Crawford, DC. Using Electronic Health Records To Generate Phenotypes For Research. Curr Protoc Hum Genet 2019; 100 (1): e80. PubMed PMID:30516347 PubMed Central PMC6318047.
- Restrepo, NA, Laper, SM, Farber-Eger, E, Crawford, DC. Local genetic ancestry in CDKN2B-AS1 is associated with primary open-angle glaucoma in an African American cohort extracted from de-identified electronic health records. BMC Med Genomics 2018; 11 (Suppl 3): 70. PubMed PMID:30255811 PubMed Central PMC6157155.
- Crawford, DC, Restrepo, NA, Diggins, KE, Farber-Eger, E, Wells, QS. Frequency and phenotype consequence of APOC3 rare variants in patients with very low triglyceride levels. BMC Med Genomics 2018; 11 (Suppl 3): 66. PubMed PMID:30255797 PubMed Central PMC6156840.
- El Rouby, N, McDonough, CW, Gong, Y, McClure, LA, Mitchell, BD, Horenstein, RB, Talbert, RL, Crawford, DC, eMERGE network, Gitzendanner, MA, Takahashi, A, Tanaka, T, Kubo, M, Pepine, CJ, Cooper-DeHoff, RM, Benavente, OR, Shuldiner, AR, Johnson, JA. Genome-wide association analysis of common genetic variants of resistant hypertension. Pharmacogenomics J. 2019; 19 (3): 295-304. PubMed PMID:30237584 PubMed Central PMC6426691.
- PLoS One, Academic Editor
- PLoS Genetics, Guest Associate Editor
- Frontiers in Genetics, Specialty Chief Editor, Applied Epidemiology
Student and mentee totals, over Case Western Reserve University and entire career:
- Master’s mentees: 0/6
- Master’s committees: 0/6
- PhD mentees: 0/6
- PhD committees: 4/17