The Genomics Core has the privilege of working with many outstanding investigators that cross a wide range of research topics. Listed here are just a few of the projects that the Genomics Core has recently contributed to.

Remember to acknowledge the valuable services provided by the Genomics Core in your research papers and publications:

"This research was supported by the Genomics Core Facility of the CWRU School of Medicine's Genetics and Genome Sciences Department."

Meserve EE, Strickland KC, Miron A, Soong TR, Campbell F, Howitt BE, Crum CP (2018)
Evidence of a Monoclonal Origin for Bilateral Serous Tubal Intraepithelial Neoplasia.
Int J Gynecol Pathol. 2018 Jun 12; doi: 10.1097/PGP.0000000000000534.

Lager AM, Corradin OG, Cregg JM, Elitt MS, Shick HE, Clayton BLL, Allan KC, Olsen HE, Madhavan M, Tesar PJ (2018)
Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells.
Nat Commun. 2018 Sep 13;9(1):3708. doi: 10.1038/s41467-018-06102-7.

Madhavan M, Nevin ZS, Shick HE, Garrison E, Clarkson-Paredes C, Karl M, Clayton BLL, Factor DC, Allan KC, Barbar L, Jain T, Douvaras P, Fossati V, Miller RH, Tesar PJ (2018)
Induction of myelinating oligodendrocytes in human cortical spheroids.
Nat Methods. 2018 Sep;15(9):700-706. doi: 10.1038/s41592-018-0081-4. Epub 2018 Jul 25.

Elitt MS, Shick HE, Madhavan M, Allan KC, Clayton BLL, Weng C, Miller TE, Factor DC, Barbar L, Nawash BS, Nevin ZS, Lager AM, Li Y, Jin F, Adams DJ, Tesar PJ (2018)
Chemical Screening Identifies Enhancers of Mutant Oligodendrocyte Survival and Unmasks a Distinct Pathological Phase in Pelizaeus-Merzbacher Disease.
Stem Cell Reports. 2018 Sep 11;11(3):711-726. doi: 10.1016/j.stemcr.2018.07.015. Epub 2018 Aug 23. 

Smolko AE, Shapiro-Kulnane L, Salz HK (2018)
The H3K9 methyltransferase SETDB1 maintains female identity in Drosophila germ cells.
Nat Commun. 2018 Oct 8;9(1):4155. doi: 10.1038/s41467-018-06697-x.

Zagore LL, Sweet TJ, Hannigan MM, Weyn-Vanhentenryck SM, Jobava R, Hatzoglou M, Zhang C, Licatalosi DD (2018)
DAZL Regulates Germ Cell Survival through a Network of PolyA-Proximal mRNA Interactions.
Cell Rep. 2018 Oct 30;25(5):1225-1240.e6. doi: 10.1016/j.celrep.2018.10.012.

Hanson G, Alhusaini N, Morris N, Sweet T, Coller J (2018)
Translation elongation and mRNA stability are coupled through the ribosomal A-site.
RNA. 2018 Oct;24(10):1377-1389. doi: 10.1261/rna.066787.118. 

Soong TR, Howitt BE, Miron A, Horowitz NS, Campbell F, Feltmate CM, Muto MG, Berkowitz RS, Nucci MR, Xian W, Crum CP (2018)
Evidence for lineage continuity between early serous proliferations (ESPs) in the Fallopian tube and disseminated high-grade serous carcinomas.
J Pathol. 2018 Nov;246(3):344-351. doi: 10.1002/path.5145. Epub 2018 Sep 27. PubMed PMID: 30043522.

Hung S, Saiakhova A, Faber ZJ, Bartels CF, Neu D, Bayles I, Ojo E, Hong ES, Pontius WD, Morton AR, Liu R, Kalady MF, Wald DN, Markowitz S, Scacheri PC (2019)
Mismatch repair signature mutations activate gene enhancers across human colorectal cancerepigenomes.
Elife. 2019 Feb 13;8. pii: e4070. doi: 0.7554/eLife.4070.

Papp-Wallace KM, Zeiser ET, Becka SA, Park S, Wilson BM, Winkler ML, D'Souza R, Singh I, Sutton G, Fouts DE, Chen L, Kreiswirth BN, Ellis-Grosse EJ, Drusano GL, Perlin DS, Bonomo RA (2019)
Ceftazidime-Avibactam in Combination with Fosfomycin: A Novel Therapeutic Strategy AgainstMultidrug-Resistant Pseudomonas aeruginosa.
J Infect Dis. 2019 May 17. pii: jiz149. doi: 10.1093/infdis/jiz149. 

McHugh DR, Steele MS, Valerio DM, Miron A, Mann RJ, LePage DF, Conlon RA, Cotton CU, Drumm ML, Hodges CA (2018)
A G542X cystic fibrosis mouse model for examining nonsense mutation directed therapies. 
PLoS One. 2018;13(6):e0199573. doi: 10.1371/journal.pone.0199573. eCollection 2018. 

Hao S, Roesch EA, Perez A, Weiner RL, Henderson LC, Cummings L, Consiglio P, Pajka J, Eisenberg A, Yeh L, Cotton CU, Drumm ML (2019)
Inactivation of CFTR by CRISPR/Cas9 alters transcriptional regulation of inflammatory pathways and other networks.
J Cyst Fibros. 2019 May 21. pii: S1569-1993(19)30105-5. doi: 10.1016/j.jcf.2019.05.003. 

Patel R, Zhang L, Desai A, Hoenerhoff MJ, Kennedy LH, Radivoyevitch T, Ban Y, Chen XS, Gerson SL, Welford SM (2019)
Mlh1 deficiency increases the risk of hematopoietic malignancy after simulated space radiation exposure.
Leukemia. 2019 May;33(5):1135-1147. doi: 10.1038/s41375-018-0269-8.