The Biochemistry faculty has a wide range of research interests from cell biology to molecular biophysics. Primary faculty have their main affiliation with the Department of Biochemistry and are based within the department. Secondary faculty have their main affiliation with other departments or centers, including the RNA center. Students can thus work in virtually any field in current biomedical research.
Primary Faculty
| Faculty Member | Area of Research |
|---|---|
| Ryan Arvidson | Bioinformatics-based approaches to understanding nervous system circuitry and signaling. |
| Kaixiang Cao | Elucidating mechanisms underlying stem cell differentiation and mammalian development with genetic, epigenetic, and genomic approaches. |
| Paul Carey | Protein-ligand interaction and Raman spectroscopy. |
| J. Alan Diehl | Cell cycle regulation and ubiquitin-dependent protein degradation; integrated stress response and ncRNAs in regulation of the circadian clock and tumorigenesis. |
| Thomas Gerken | Biosynthesis of O-linked glycans. |
| Hung-Ying Kao | Signaling pathways controlled by transcription corepressors and histone deacetylases. |
| William C. Merrick | Mechanism and regulation of eukaryotic protein biosynthesis. |
| Nelson F. B. Phillips | Biochemical mechanisms of tissue-specific transcription factors. |
| Marianne Pusztai-Carey | Structure and function of the insecticidal proteins expressed by the Bacillus thuringiensis family. |
| David Samols | The mammalian response to inflammation; function and regulation of the acute phase reactant, C-reactive protein. |
| Martin Snider | Intracellular movement of cell-surface receptors during endocytosis. |
| Focco van den Akker | Structure-function and inhibitor design studies to combat antibiotic resistance. |
| Susan Wang | Mechanistic studies of radical S-adenosyl-L-methionine enzymes. |
| Vivien C. Yee | Structure-function studies of enzymes and prion proteins using X-ray crystallography. |
Emeriti Faculty
| Faculty Member | Area of Research |
|---|---|
| Nikki Harter | Molecular mechanisms of adult stem cells and the transformation of melanocytes. |
| Menachem Shoham | Drug discovery against infectious diseases, heart disease and cancer. |
| Pieter deHaseth | Mechanism of RNA polymerase-DNA interactions. |
RNA Center Faculty
| Faculty Member | Area of Research |
|---|---|
| Jonatha Gott | Mechanistic studies of RNA editing in Physarum mitochondria. |
| Eckhard Jankowsky | Molecular Mechanisms of RNA Helicases |
| Donny Licatalosi | Gene expression, alternative RNA regulation, protein-RNA interactions, mammalian germ cell biology. |
| Jo Ann Wise | Mechanism and regulation of pre-mRNA splicing in S. pombe. |
Secondary Faculty
| Faculty Member | Area of Research |
|---|---|
| Kristian Baker | Mechanisms of the nonsense-mediated mRNA decay. |
| Nathan Berger | PolyADP-ribose metabolism in DNA repair and replication. |
| Robert Bonomo | β-lactamases and antibiotic resistance. |
| Henri Brunengraber | Nutritional Biochemistry. |
| David Buchner | Epigenetics, gene expression, obesity and diabetes, insulin signaling, glucose. |
| Magdalena Grabowska | Prostate cancer. |
| Vincent Hascall | Structure, function and metabolism of proteoglycans and hyaluronan in connective tissues. |
| Faramarz Ismail-Beigi | Diabetes, thyroid disease. |
| Jonathan Karn | HIV, AIDS, transcription, chromatin, retroviral vectors. |
| Ahmad Khalil | Epigenetic Regulation of the Genome, Histone Modifications and Non-coding RNA. |
| Anton Komar | Protein synthesis, protein folding and translational control of gene expression in eukaryotic cells. |
| Donal Luse | Eukaryotic gene transcription and RNA polymerase. |
| Vincent Monnier | Biochemistry of aging. |
| Krisztina Papp-Wallace | β-lactamases and antibiotic resistance. |
| Paul Park | Mechanism of action of rhodopsin and other G protein-coupled receptors. |
| Jun Qin | Biomolecular NMR spectroscopy, signal transduction. |
| Parameswaran Ramakrishnan | Regulation of signal transduction in health and disease: autoimmune diabetes, inflammatory diseases and cancer. |
| Ganes Sen | Mammalian gene expression anantiotensin-converting enzyme and interferon. |
| Robert Silverman | Role of the OAS-RNase L pathway in antiviral innate immunity and cancer. |
| Marion J. Skalweit | Mechanisms of antimicrobial resistance. |
| Jonathan Stamler | Redox-based cellular regulation and signal transduction, and in particular the role of protein S-nitrosylation. |
| Derek Taylor | Structure and molecular mechanisms of macromolecular machines involved in DNA maintenance and RNA maturation and biogenesis. |
| Saba Valadkhan | Role of the mammalian long non-coding RNAs in neurogenesis and cancer. |
| Martina Veigl | DNA repair, mutation analysis in bacterial and mammalian gene targets, mutagenic effects of nucleotide pool imbalance, colon cancer, genetic susceptibility, environmental mutagens. |
Other Biochemistry Trainers
| Faculty Member | Area of Research |
|---|---|
| Maria Hatzoglou | Molecular mechanisms of the cellular response to stresses, including inflammation and diabetes. |
| Afshin Dowlati | Biology of thoracic malignancies, with emphasis on translational aspects of drug development. |