Xiao Li, PhD

Assistant Professor
Department of Biochemistry
School of Medicine
Member
Center for RNA Science and Therapeutics
School of Medicine
Assistant Professor
Department of Biomedical Engineering
Case School of Engineering

Research Information

Research Interests

Human diseases are caused by the interplay between gene and environment.  Deep sequencing reveals millions of mutations between the genomes of unrelated individuals; however, the consequences of these mutations remain mostly unclear. Besides genetic impact, the actual development of individuals' disease phenotypes is largely subjected to their lifestyle, behavior, and environmental exposures. Characterizing these highly diverse and dynamic factors goes beyond what can be achieved with regular medical records.

To enable precision medicine and health, my lab seeks to address these gaps by investigating the areas which have not been extensively studied before. On the genetic side, we will focus on investigating the impact of genetic variation on post-transcriptional regulation to study the mechanistic role of RNA binding proteins in human diseases. On the non-genetic side, we will exploit the emerging wearable technology for deep phenotypical and environmental profiling. With the big data strategy integrating multi-omics, phenotypical, and environmental datasets, we are delineating the gene-environment interaction at a personal resolution to achieve precise understandings of human diseases.

Publications

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