Dr. Chen-Han Wilfred Wu received his MD degree from National Taiwan University in Taipei, Taiwan. He completed his urology residency at National Taiwan University Hospital. Wilfred came to the United States initially for advanced laparoscopic surgery and got interested in genetics. He then obtained his Ph.D. in human genetics from the University of Utah under the direction of Dr. Lynn Jorde. Wilfred did his clinical genetics genomics and clinical biochemical genetics training at the Harvard Medical School program. When he was in Boston, he was mentored by Dr. Friedhelm Hildebrandt for his research. In fall 2021, Wilfred will move to Case Western Reserve and found the "Urogenetics" program to provide care and research opportunities to patients with urological diseases.
Our lab is at the forefront of genomics in urological conditions, leveraging large datasets from both phenotypic information gleaned from electronic medical records (EMR) and genomic data from comprehensive sequencing techniques. We offer the unique experience of working in both dry and wet lab environments, with data access to resources like the UK Biobank, All-of-Us, TriNetX, University Hospitals EMR, and our in-house experiments. Our current active projects span areas such as kidney stones, male infertility, and transgender studies, providing a rich and diverse research environment to advance your academic career.
Research Information
Research Projects
Dr. Wu is founding the “Urogenetics” Program, and the Wu Laboratory will serve as the first research branch of the program. This is a collaboration between the Urology Institute at University Hospitals and the Department of Genetics and Genome Sciences. We study all urological diseases. Currently in-lines are:
- Kidney stone diseases
- Genitourinary cancers: renal, bladder/urothelial, and prostate cancers
- Congenital anomalies of kidneys and urinary tracts
- Reproductive health/infertility
- Transgender biology
- Benign prostatic hyperplasia
- Voiding dysfunction
We employ both dry and wet lab approaches, and span between bedside and bench. These include studies of:
- Germline genetics and genome
- Somatic genetics and genome
- Transcriptome
- Epigenome
- Biochemical genetics, metabolome, and proteome
- Phenotypes
- Environmental factors
- Clinical outcomes