2019 ABSTRACTS

Image of two physicians outside of an operating room

Abstracts have been submitted for the 2019 Annual Retreat in the Study Areas below. Prizes will be awarded for students and fellows with the best poster presentations. 

Loss of Neuregulin 3 in dopaminergic neurons leads to dysregulated dopamine transients and cognitive deficits

Wanpeng Cui, Nannan Gao, Zhaoqi Dong, Hongsheng Zhang, Bin Luo, Honhyang Jing, Hongsheng Wang,  Wencheng Xiong, and Lin Mei

Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH  


CUL3 deficiency causes social deficits and anxiety-like behaviors by impairing excitation-inhibition balance via promoting Cap-dependent translation

Zhaoqi Dong*,1, Wenbing Chen*,2, Chao Chen3, Hongsheng Wang1, Wanpeng Cui1, Zhibing Tan1, Heath Robinson1, Nannan Gao1, Bin Luo2, Lei Zhang1, Kai Zhao1, Wen-Cheng Xiong1,4 and Lin Mei1,4,5

1Department of Neurosciences, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH
2Institute of Life Science, Nanchang University, Nanchang, China.
3The Laboratory of Vector Biology and Control, College of Engineering, Beijing Normal University, Zhuhai, China.
4Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH
5Corresponding author
*These authors contributed equally.


Brain to toe therapeutic lifestyle changes (TLC) bench-to-clinic-to-community systems approaches to climacteric 

Melita M. Nasca, Ph.D.*, Francine K. Welty, M.D., Ph.D., Jin-Rong Zhou, Ph.D.
Cardiovascular Division and Nutrition Metabolism Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School Boston, MA


DGCR2, a schizophrenia risk gene, regulates synaptic transmission, anxiety and hippocampal-prefrontal synchrony

Heath Robinson, Bin Luo, Wenbing Chen, Zhibing Tan, Lin Mei

Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH


Tourism, Pathogens, Captive Environments and Disease Transmission 

Jeanne Marie Stumpf-Carome

Anthropology, Kent State University Geauga Campus, Burton, OH 


The hippocampal-prefrontal pathway in modulation of sleep and wakefulness

Zhibing Tan, Yu Liu, Heath Robinson, Wen-Cheng Xiong, Lin Mei
Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH


ErbB4 labels a novel group of excitatory interneurons in dorsal spinal cord and mediates thermal pain sensation

Hongsheng Wang1, Wanpeng Cui1, Zhaoqi Dong1, Wen-Cheng Xiong1,2, Lin Mei1,2

1Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH
2Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH


Wising-up: designing a course for the future –Cog Science 301/401

Peter Whitehouse and Nicholas Brennecke 

Department of Neurology, Case Western Reserve University School of Medicine, Cleveland, OH


Neuropsychological Rehabilitation: Applying science to clinical practice

Jill Winegardner

Neurological Institue, University Hopitals Cleveland Medical Center, Cleveland, OH


 

 

 

Astrocytic neogenin regulating netrin-1, a pathway critical for astrocyte tiling and blood vessel maturation in mouse cortical brain

Ling-Ling Yao1,2,#, Jin-Xia Hu2,3,#, Qiang Li2,4,#, Xiao Ren1,5, Jun-Shi Zhang1,6, Dong Sun1,2, Hong-Sheng Zhang1,2, Dae-Hoon Lee1, YongGang Wang5, Lin Mei1,2 and Wen-Cheng Xiong1,2,*

1Department of Neurosciences, Case Western Reserve University, Cleveland, OH
2Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA
3Department of Neurology, The affiliated hospital of Xuzhou Medical University, Xuzhou, Jiangsu Province, China
4Department of Hand Surgery, China-Japan Union Hospital, Jilin University, Changchun, China
5Department of Neurology, Renji hospital, Shanghai Jiaotong University, Shanghai, China
6Department of Neurology, Huaihe Hospital, Henan University, Kaifeng, Henan, China
#: equal contributions.  *, corresponding author.


Brief treatment with P7C3-A20 in chronic blast-mediated traumatic brain injury, one year after blast exposure, improves cognition, restores the blood-brain barrier, and reduces neurodegeneration.

Edwin Vázquez-Rosa1,2*, Min-Kyoo Shin1,2*, Matasha Dhar1,2*, Kalyani Chaubey1,2, Coral Cintrón-Pérez1,2, Xinmiao Tang3, Xudong Liao3, Emiko Miller1,2, Yeojung Koh1,2, Danyel Crosby2 Rachel Schroeder4, Josie Emery4, Terry C. Yin4, Hisashi Fujioka5, Matthew M. Harper6, Mukesh K. Jain1,3 and Andrew A. Pieper1,2# 

1Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 
2Department of Psychiatry Case Western Reserve University, Geriatric Research Education and Clinical Centers, Louis Stokes Cleveland VAMC, Cleveland, OH 
3Department of Medicine, Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 
4The Department of Psychiatry, University of Iowa, Iowa City IA; 
5Electron Microscope Facility, Case Western Reserve University School of Medicine, Cleveland, OH 
6Veterans Affairs Medical Center, Center for the Prevention and Treatment of Visual Loss, Iowa City IA; The University of Iowa Departments of Ophthalmology and Visual Sciences and Molecular Physiology and Biophysics.
*co-first authors, # corresponding author


 

Proteomic alterations after chronic treatment of the TgF344-AD rat model of Alzheimer’s disease with the neuroprotective compound P7C3- S321

Kalyani Chaubey, Min Kyoo Shin, Edwin Vázquez-Rosa, Coral J. Cintrón-Pérez, Matasha Dhar, Yeojung Koh, and Andrew A. Pieper 
Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH
Department of Psychiatry Case Western Reserve University, Cleveland, OH
Geriatric Research Education and Clinical Center, Louis Stokes Cleveland VAMC, Cleveland, OH


The first-ever CNV analysis in Latin American Parkinson's disease patients 

Elif Irem Sarihan1, Lisa-Marie Niestroj2, Eduardo Perez-Palma1, Miguel Inca-Martinez1
Dennis Lal1,2,3,4, Ignacio F. Mata1 on behalf of the Latin American Research consortium on the Genetics of Parkinson’s Disease (LARGE-PD)

1Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH
2Cologne Center for Genomics, University of Cologne, Germany
3Stanley Center for Psychiatric Research, Broad Institute of MIT & Harvard, Cambridge, MA
4Epilepsy Center & Department of Neurology, Neurological Institute, Cleveland Clinic, Cleveland, OH


ErbB4 functioning in fear memory within the main part of intercalated cells

Chen Shen, Heath Robinson, Hongsheng Wang and Lin Mei

Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH

LRP4 is critical for muscle spindle development

Rangjuan Cao, Hongyang Jing, Guanglin Xing, Hongsheng Zhang, Lin Mei

Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH


A Nail Patella Syndrome-causing human Lmx1b variant disrupts mouse serotonin neuron development

Brent A. Eastman, William C. Spencer, Evan S. Deneris. 

Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH


GRP78 is essential for NMJ formation and maintenance

Hongyang Jing1,2, Lei Li2, Guanglin Xing2, Hongsheng Zhang2, Zhaoqi Dong2, Wanpeng Cui2, Zheng Yu2, Bin Luo2, Nannan Gao2, Wencheng Xiong2, Lin Mei*2,3

1Institute of Life Science, Nanchang University, Nanchang, China
2Department of Neuroscience, School of Medicine, Case Western Reserve University, Cleveland, OH
3Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH
*Corresponding author


ErbB4 Can Promote Inhibitory Synapse Formation by Cell Adhesion, Independent of Its Kinase Activity

Bin Luo1, Ziyang Liu1, Wenbin Chen1, Peng Chen1, Erkang Fei1, and Lin Mei2, 3

1 Institute of Life Science, Nanchang University, Nanchang, China
2 Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH 
3 Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH


Response to Patching in Amblyopic Patients with and without Fusion Maldevelopment Nystagmus

Jordan Murray1,2, Matteo Scaramuzzi1,2, Aasef Shaikh3,4, Fatema Ghasia1,2,3

1Department of Ophthalmology, Cole Eye Institute Cleveland Clinic
2Ocular Motility and Visual Neurosciences Lab, Cleveland Clinic
3Department of Neurology, Case Western Reserve University
4Daroff Dell’Osso Ocular Motility Lab, Cleveland VA Medical Center


Enhancement of spontaneous glutamate release by group I mGluRs in the Medial Nucleus of the Trapezoid Body 

Kang Peng1, Xiaoyu Wang2, Yuan Wang2, Dainan Li3, Hai Huang3, Yong Lu1 
1Department of Anatomy and Neurobiology, College of Medicine, Northeast Ohio Medical University, Rootstown, OH 
2Department of Biomedical Science, Program in Neuroscience, Florida State University College of Medicine, Tallahassee, FL 
3Department of Cell and Molecular Biology, Brain Institute, Tulane University, New Orleans, LA


Asparagine 88 to lysine (N88K), a prevalent congenital myasthenic syndrome mutation of rapsyn, impairs neuromuscular junction by disrupting agrin signaling

Guanglin Xing, Hongyang Jing, Lei Zhang, Zhaoqi Dong, Wenbing Chen, Hongsheng Wang, Rangjuan Cao, Wen-Cheng Xiong, Lin Mei*

Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH
*Correspondence: lin.mei@case.edu


Regulation of chromatin accessibility and Pet1/FEV binding during serotonergic (5-HT) neuron development

Xinrui Zhang, W. Clay Spencer, Katherine Lobur, and Evan Deneris
Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 


 

Zinc-finger CCHC-domain containing protein 6 (Zcchc6) is translocated to mitochondria and modulates neuronal cells survival 

Mohammad Y Ansari and Tariq M Haqqi
Department of Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH


Transgenic Overexpression of GPNMB Protects Against MPTP-Induced Neurodegeneration

Kevin Budge1,2, Matthew Neal3, Jason R. Richardson3, Fayez Safadi1,2,4

1Department of Anatomy and Neurobiology, Northeast Ohio Medical University (NEOMED), College of Medicine, Rootstown, OH 
2School of Biomedical Sciences, Kent State University, Kent, OH 
3Environmental Health Sciences Department, Florida International University, Miami, FL 
4Rebecca D. Considine Research Institute, Akron Children’s Hospital, Akron, OH


Study of AR-DNA association in Spinal Bulbar Muscular Atrophy

Giuliana Coatti, Helen Miranda

Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH


Evaluation of CNS Blockade of AMYR on Pramlintide function in Alzheimer’s Disease.

Rachel Corrigan, John Grizzanti and Gemma Casadesus

School of Biomedical Sciences, Kent State University, Kent, OH


Reversible loss of neuronal function in a mouse model of demyelination/remyelination 

Aniruddha Das1, Jason Suh1, Chinthasagar Bastian1, Lexie Trestan1, Thomas Jaramillo2, Bruce D. Trapp1, Selva Baltan1, and Hod Dana1

1Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH
2Rodent Behavioral Core, Lerner Research Institute, Cleveland, OH


Effects of variable beta-amyloid (Ab1-42) fragment size on expression of pro-inflammatory, anti-inflammatory, and autophagy genes in human microglia cells.

Eric Dyne, Junfeng Li, Ronghui Song, Bing Yu, Songping Huang, Min-Ho Kim

Neuroscience, School of Biomedical Sciences, Department of Biological Sciences, Kent State University, Kent OH


Role of macrophage phenotype and macrophage/DRG site-specific interactions on neurite outgrowth in adult DRG neurons in vitro

Franklin D. Echevarria and Richard E. Zigmond
Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH


Selective deletion of AMPA receptors on oligodendrocytes prevents demyelination and axonal injury in autoimmune demyelination

Kirsten S. Evonuk1, Ryan E. Doyle1, Carson E. Moseley2, Hannah Monyer3, and Tara M. DeSilva1

1Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH
2Department of Pathology, University of Alabama at Birmingham, Birmingham, AL
3Department of Clinical Neurobiology, Medical Faculty of Heidelberg, University of Heidelberg - German Cancer Research Center, Heidelberg, Germany


A role of lamin A/C in preventing neuromuscular junction decline in aged mice

Nannan Gao*, Kai Zhao*, Lei Xiong, Guanglin Xing, Hongyang Jing, Haohan Guo, Wen-Cheng Xiong, Lin Mei#

Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH
*: equal contributions; #: corresponding author


Optimizing dance interventions to improve motor function in people with Parkinson’s disease and older adults

Peter Gates1, Jin Hyun Kim2, Robert Melczak2, Fred Discenzo3, Joan Meggitt4, Angela L. Ridgel2

1Biomedical Sciences, Kent State University, Kent OH
2Exercise Science/Physiology, Kent State University, Kent OH
3Rockwell Automation, Cleveland OH (retired)
4School of Theatre and Dance, Kent State University, Kent OH


Using linkage analysis to identify novel gene-gene interactions in Alzheimer’s disease

Michelle Grunin1,2 , Nicholas R. Wheeler1, William S. Bush 1,2 , Jonathan L. Haines1,2 , Alzheimer's Disease Sequencing Project

1Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH
2Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH


The Role of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) in neurodegeneration

Yeojung Koh1, Min-Kyoo Shin1, Coral J Cintrón-Pérez1, Edwin F Vázquez Rosa1, Dawn Dawson2, Stephen Fink2, Li Hongyun2, Joseph Ready3, Sanford Markowitz2, Andrew A. Pieper1

1Department of Neurosciences, Case Western Reserve University School of Medicine; Harrington Discovery Institute, University Hospitals of Cleveland; Geriatric Research Education and Clinical Centers, Louis Stokes VA Medical Center of Cleveland, OH 
2Case Comprehensive Cancer Center; Case Western Reserve University, Cleveland, OH
3Department of Biochemistry, UTSWMC, Dallas, TX


ADCYAP1/PACAP and its potential regulatory long non-coding RNA may be implicated in the neurodegenerative process of MS patients

Saloni Lad1, Aaron Perles2, Ajai Tripathi2, Ranjan Dutta1,2
 
1Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
2Department of Neurosciences, Cleveland Clinic Lerner Research Institute, Cleveland, OH 


Pathogenic CLP1 p.R140H mutation alters mRNA processing in human motor neurons

Geneva LaForce1, Jordan Farr1, Evren Gumus2, Cydni Akesson1, Merve Yazol3, Eric J Wagner4, Polyxeni Philippidou5, Ashleigh E. Schaffer1

1Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH 
2Department of Medical Genetics, Faculty of Medicine, University of Harran, Sanliurfa, Turkey 
3Department of Radiology, Sanliurfa Education and Research Hospital, Sanliurfa, Turkey 
4Department of Biochemistry and Molecular Biology, University of Texas Medical Branch at Galveston, Galveston, TX 
5Department of Neurosciences, Case Western Reserve University, Cleveland, OH 


Protective genetic variants in the mid-western Amish 

Leighanne R Main1, Michelle C Disher1, Yeunjoo Song1, Renee Laux1, Kristy Miskimen1, Michael L Cuccaro2,3, Paula Ogrocki4, Alan J Lerner1,4, Jeffery M. Vance2,3, M Denise Fuzzell1, Sarada Fuzzell1, Jane Sewell1, Laura J Caywood2, Michael Prough3, Bill Scott2,  Larry D. Adams2, Jason E. Clouse2, Sharlene D. Herington2, Margaret A. Pericak-Vance3,5 and Jonathan L. Haines1 

1Case Western Reserve University School of Medicine, Cleveland, OH
2University of Miami, Miami, FL
3John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL
4University Hospitals Cleveland Medical Center, Cleveland, OH 
5The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL


Neuroimmune axis: ADAR-mediated RNA editing plays a role in molecular evolution of West Nile Virus

Heather Milliken Mercer1,2, Noel-Marie Plonski3, Caroline Nitirahardjo2, Michael Miyamoto4, Marta Wayne4, Maureen Long5, Helen Piontkivska2,3,6
 
1Department of Biology, University of Mount Union, Alliance, OH 
2Department of Biological Sciences, Kent State University, Kent, OH 
3School of Biomedical Sciences, Kent State University, Kent, OH
4Department of Biology, University of Florida, Gainesville, FL
5College of Veterinary Medicine, University of Florida, Gainesville, FL 
6Brain Health Research Institute, Kent State University, Kent, OH 


Consequential timeline of optic nerve and retinal changes compared with functional imaging assessments in autoimmune demyelination

Gabrielle Mey1, Kirsten S. Evonuk1, Rupesh Singh2, Minzhong Yu2, Bela Anand-Apte2, Neal S. Peachey2, and Tara M. DeSilva1

1Department of Neuroscience, Cleveland Clinic Lerner Research Institute, Cleveland, OH 
2Department of Ophthalmic Research, Cleveland Clinic Cole Eye Institute, Cleveland, OH 


Oncomodulin is required for the conditioning lesion response in dorsal root ganglion neurons in vivo

Jon P. Niemi1, Talia DeFrancesco Oranburg1, Andrew Cox2, Jane A. Lindborg1, Franklin D. Echevarria1, Jemima McCluskey2, Dwayne D. Simmons2, and Richard E. Zigmond1

1Department of Neurosciences, Case Western Reserve University, Cleveland OH  
2Department of Biology, Baylor University, Waco TX 


Vps35 D620N knock-in mice display increased susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity

Mengyue Niu, Fanpeng Zhao, Sandy Torres, Wenzhang Wang, Xiongwei Zhu

Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH


APP promotes osteoblast survival and bone formation by regulating mitochondrial function and preventing oxidative stress

Jin-Xiu Pan1,2,3,4, Fulei Tang2,3, Fei Xiong5, Lei Xiong1,2,3,4, Lin Mei1,2,3,4, and Wen-Cheng Xiong1,2, 3,4

1Department of Neuroscience, Case Western Reserve University, Cleveland, OH
2Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA
3Charlie Norwood VA Medical Center, Augusta, GA
4Louis Stokes Cleveland VAMC, Cleveland, OH
5The Center for Biomedical Research, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan China


Dynamin‐like protein 1 cleavage by calpain in Alzheimer’s disease

Changjuan Shao, Sirui Jiang, Fangqiang Tang, Wenzhang Wang, Xiongwei Zhu

Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH


Heterogeneity of the Regenerative Response of Dorsal Root Ganglion Neurons to a Conditioning Lesion
 
Jeong Seo1, Sanika Paranjape1, David Ginty2, Richard Zigmond1

1Case Western Reserve University, Department of Neuroscience, Cleveland, OH
2Harvard University, Department of Neurobiology, Boston, MA


Young Adults with Down Syndrome have Increased Levels of Soluble TREM2 and Inflammatory Markers

Grace Weber*,1, Katherine Koenig*,2, Maria Khrestian1, Yvonne Shao1, Marie Gramm1, Dennis Lal1
James  B. Leverenz3, Lynn M. Bekris1

1Cleveland Clinic, Genomic Medicine Institute, Cleveland, OH 
2Cleveland Clinic, Imaging Institute, Cleveland, OH
3Cleveland Clinic, Lou Ruvo Center for Brain Health, Neurological Institute, Cleveland, OH
*Contributed equally


Ependymal VPS35 promotes ependymal cell differentiation, suppresses microglial activation, and prevents neonatal hydrocephalus

Kong-yan Wu1, Fu-Lei Tang2, Hyunjin Song2, Lin Mei1, Wen-Cheng Xiong1

1Department of Neuroscience, Case Western Reserve University, Cleveland, OH
2Augusta University, Augusta, GA


LRP4 Deficiency in Astrocytes Exacerbates Alzheimer’s-Associated Pathology and Cognitive Dysfunction

Hongsheng Zhang, Wenbing Chen, Shu Shu, Zhaoqi Dong, Wanpeng Cui, Kai Zhao, Lei Zhang, Lingling Yao, Wencheng Xiong, Lin Mei
Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH


 

 

Efficient Non-viral Gene Therapy for Stargardt’s Disease with pH-Sensitive Multifunctional Lipid ECO Plasmid DNA Nanoparticles                                   

Da Sun1, Rebecca M. Schur1, Avery E. Sears2,†, Song-Qi Gao2, Amita Vaidya1, Wenyu Sun1, Akiko Maeda2, Timothy Kern2,†, Krzysztof Palczewski2,† and Zheng-Rong Lu1

1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH
2Department of Pharmacology, Case Western Reserve University, Cleveland, OH
Current address: Gavin Herbert Eye Institute, Department of Ophthalmology and Department of Physiology and Biophysics, University of California, Irvine, CA


Microbiota-associated cytokines robustly enhance the ability of FoxP3+ Tregs to suppress EAE

Julie Y. Zhou and Brian A. Cobb

Department of Pathology, Case Western Reserve University, Cleveland, OH