My lab is interested in understanding how the immune system responds to a variety of insults (e.g. bacteria, viruses, tumors) to control human diseases (e.g. infectious diseases and cancer). Increasing evidence has implicated that metabolism plays a crucial role in shaping immune cell phenotype and function. Our studies aim to investigate the interactions between metabolism and innate immune response in the settings of lung infection and cancer.
Research Information
Research Interests
My lab is interested in understanding how the immune system responds to a variety of insults (e.g. bacteria, viruses, tumors) to control human diseases (e.g. infectious diseases and cancer). Increasing evidence has implicated that metabolism plays a crucial role in shaping immune cell phenotype and function. Our studies aim to investigate the interactions between metabolism and innate immune response in the settings of lung
infection and cancer.
In particular, our research focus includes the following:
- Decipher the essential metabolic pathways that regulate and support the functions of immune efforts,including but not limited to monocytes and macrophages;
- Identify the role of key host factors in driving metabolic reprogramming of immune cells;
- Investigate cell-cell communication between immune and non-immune cells at the interface of metabolism and immune cell function.
The vision of my lab is to discover how immunometabolism controls human disease so that we can manipulate immune and metabolic networks to achieve desired outcomes, ultimately improving treatment options for human disease, especially infectious diseases and cancer, which are still of great concern to us today.
Publications
- Liu X, Boyer MA, Holmgren AM, Shin S.
Legionella-Infected Macrophages Engage the Alveolar Epithelium to Metabolically Reprogram Myeloid Cells and Promote Antibacterial
Cell Host Microbe, 28(5):683–698 (2020) - Liu X and Shin S.
Listening In: Plasmacytoid DC, Monocyte-Derived DC, and Neutrophil Crosstalk in Antifungal Defense.
Cell Host Microbe, 28(1):9-11 (2020) - Liu X and Shin S.
Viewing Legionella Pneumophila Pathogenesis through an Immunological Lens.
J Mol Biol, 431(21):4321-4344 (2019) - Liu X, Luo D, Yang N.
Cytosolic Low Molecular Weight FGF2 Orchestrates RIG-I-Mediated Innate Immune Response.
J Immunol, 195(10):4943-52 (2015) - Zhao Q*, Liu X*, Zhang D, Zhang L, Luo D.
Hexa-Acylated LPS-Lipid A Deploys the Appropriate Level of Fibrin to Confer Protection through Myd88.
Int J Infect Dis, 33:142-8 (2015) *co-first authors. - Liu X, Lai C, Wang K, Xing L, Yang P, Duan Q, Wang X.
A Functional Role of Fibroblast Growth Factor Receptor 1 (FGFR1) in the Suppression of Influenza A Virus Replication.
PloS One, 10(4):e0124651 (2015) - Liu X, Yang N, Tang J, Liu S, Luo D, Duan Q, Wang X.
Downregulation of Angiotensin-Converting Enzyme 2 by the Neuraminidase Protein of Influenza A (H1N1) Virus.
Virus Res, 185:64-71 (2014) - Yang P, Deng J, Li C, Zhang P, Xing L, Li Z, Wang W, Zhao Y, Yan Y, Gu H, Liu X, Zhao Z, Zhang S, Wang X, Jiang C.
Characterization of the 2009 Pandemic A/Beijing/501/2009 H1N1 Influenza Strain in Human Airway Epithelial Cells and Ferrets.
PloS One, 7(9): e4618 (2012)