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J. Alan Diehl, PhD
ChairDepartment of BiochemistrySchool of MedicineProfessorDepartment of BiochemistrySchool of MedicineDeputy Director for Case Western Reserve UniversityCase Comprehensive Cancer CenterMemberMolecular Oncology ProgramCase Comprehensive Cancer CenterPhone: 216.368.0268
I research cell cycle regulation, acquired resistance to CDK4/6 inhibitors, ubiquitin-dependent protein degradation, unfolded Protein Response and Tumor Progression, Non-coding RNA, and the circadian clock.
Curtis J. Donskey, MD
Professor of MedicineDivision of Infectious Diseases & HIV MedicineSchool of MedicineEmail: curtis.donskey@case.edu
Phone: 216.791.3800
I focus on mechanisms by which intestinal microflora inhibit colonization by pathogens, in addition to transmission of C diff and other nosocomial pathogens.
Afshin Dowlati, MD
ProfessorDepartment of MedicineDivision of Hematology and OncologySchool of MedicineAssociate Director for Clinical ResearchCase Comprehensive Cancer CenterMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: axd44@case.edu
Phone: 216.844.1228
A significant effort of our research lab is to identify novel therapeutics for small cell lung cancer. There has been little progress in the clinical management of this disease over the last three decades due mainly to our limited knowledge about the underlying mechanisms driving this malignancy. Our research is focused on the basic and translational aspects of target validation and drug development, and we are also uniquely positioned to perform preclinical studies of novel drugs in cancer models with the eventual goal of taking them into the clinic.
Donna M. Driscoll, PhD
Email: driscod@ccf.org
Phone: 216.445.9758
My areas of investigation include RNA editing, translational recoding events, and posttranscriptional gene regulation.
Mitchell Drumm, PhD
Connie and Jim Brown Professor in Cystic Fibrosis ResearchProfessorDepartment of Genetics and Genome SciencesSchool of MedicineProfessorDepartment of PediatricsVice ChairmanClinical and Translational ResearchDirectorThe Research Institute for Children’s HealthEmail: mitchell.drumm@case.edu
Phone: 216.368.6893
My research focuses on cystic fibrosis, mendelian disorders, and gene editing.
Colin Drummond, PhD, MBA
Assistant Department ChairDepartment of Biomedical EngineeringCase School of EngineeringSchool of MedicineProfessorDepartment of Biomedical EngineeringCase School of EngineeringSchool of MedicineEmail: colin.drummond@case.edu
Phone: 216.368.6970
My research focuses on simulation and applied informatics to improve health-care decision-making; much of this research has a strong translational focus, resulting in collaboration with patient care and health care systems on clinical trials. More recently, research has centered on the utility of wearable technologies for human performance assessment and conversational agents in enhancing the quality of life for isolated patients.
George R. Dubyak, PhD
ProfessorDepartment of Physiology and BiophysicsSchool of MedicineProfessorDepartment of PathologySchool of MedicineProfessorDepartment of PharmacologySchool of MedicineMemberImmune Oncology ProgramCase Comprehensive Cancer CenterEmail: george.dubyak@case.edu
Phone: 216.368.5523
Cell signaling with a focus on inflammasome complexes that regulate caspase-mediated maturation of IL-1 family cytokines and cell death via gasdermin-family pore forming proteins. Other studies focus on ion channels and G protein-coupled receptors in multiple leukocyte types in innate and adaptive immunity.
Dominique M. Durand, PhD
DirectorNeural Engineering CenterCase School of EngineeringSchool of MedicineAssociate ChairCase School of EngineeringElmer Lincoln Lindseth Professor in Biomedical EngineeringDepartment of Biomedical EngineeringCase School of EngineeringSchool of MedicineProfessorDepartment of NeurosciencesSchool of MedicineProfessorDepartment of Physiology and BiophysicsSchool of MedicineEmail: dominique.durand@case.edu
Phone: 216.368.3974
My research is in computational neuroscience, electrophysiology, and signaling networks in hippocampus.
Serpil C. Erzurum, MD
ChairLerner Research InstituteEmail: serpil.erzurum@case.edu
Our lab focuses on mechanisms that initiate and perpetuate lung inflammation and remodeling, in addition to lung diseases such as asthma and pulmonary vascular disease.