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J. Alan Diehl, PhD
Chair, Department of Biochemistry, School of MedicineProfessor, Department of Biochemistry, School of MedicineDeputy Director for Case Western Reserve University, Case Comprehensive Cancer CenterMember, Molecular Oncology Program, Case Comprehensive Cancer CenterPhone: 216.368.0268
I research cell cycle regulation, acquired resistance to CDK4/6 inhibitors, ubiquitin-dependent protein degradation, unfolded Protein Response and Tumor Progression, Non-coding RNA, and the circadian clock.
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Curtis J. Donskey, MD
Professor of Medicine, Division of Infectious Diseases & HIV Medicine, School of MedicineEmail: curtis.donskey@case.edu
Phone: 216.791.3800
I focus on mechanisms by which intestinal microflora inhibit colonization by pathogens, in addition to transmission of C diff and other nosocomial pathogens.
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Afshin Dowlati, MD
Professor, Department of Medicine, School of MedicineAssociate Director for Clinical Research, Case Comprehensive Cancer CenterMember, Developmental Therapeutics Program, Case Comprehensive Cancer CenterEmail: axd44@case.edu
Phone: 216.844.1228
A significant effort of our research lab is to identify novel therapeutics for small cell lung cancer. There has been little progress in the clinical management of this disease over the last three decades due mainly to our limited knowledge about the underlying mechanisms driving this malignancy. Our research is focused on the basic and translational aspects of target validation and drug development, and we are also uniquely positioned to perform preclinical studies of novel drugs in cancer models with the eventual goal of taking them into the clinic.
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Donna M. Driscoll, PhD
Email: driscod@ccf.org
Phone: 216.445.9758
My areas of investigation include RNA editing, translational recoding events, and posttranscriptional gene regulation.
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Mitchell Drumm, PhD
Connie and Jim Brown Professor in Cystic Fibrosis ResearchProfessor, Department of Genetics and Genome Sciences, School of MedicineProfessor, Department of PediatricsVice Chairman, Clinical and Translational ResearchDirector, The Research Institute for Children’s HealthEmail: mitchell.drumm@case.edu
Phone: 216.368.6893
My research focuses on cystic fibrosis, mendelian disorders, and gene editing.
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Colin Drummond, PhD, MBA
Assistant Department Chair, Department of Biomedical EngineeringProfessor, Department of Biomedical EngineeringEmail: colin.drummond@case.edu
Phone: 216.368.6970
My research focuses on simulation and applied informatics to improve health-care decision-making; much of this research has a strong translational focus, resulting in collaboration with patient care and health care systems on clinical trials. More recently, research has centered on the utility of wearable technologies for human performance assessment and conversational agents in enhancing the quality of life for isolated patients.
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George R. Dubyak, PhD
Professor, Department of Physiology and Biophysics, School of MedicineProfessor, Department of Pathology, School of MedicineProfessor, Department of Pharmacology, School of MedicineMember, Immune Oncology Program, Case Comprehensive Cancer CenterEmail: george.dubyak@case.edu
Phone: 216.368.5523
Cell signaling with a focus on inflammasome complexes that regulate caspase-mediated maturation of IL-1 family cytokines and cell death via gasdermin-family pore forming proteins. Other studies focus on ion channels and G protein-coupled receptors in multiple leukocyte types in innate and adaptive immunity.
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Dominique M. Durand, PhD
Director, Neural Engineering CenterAssociate Chair for Master’s programs, Department of Biomedical EngineeringElmer Lincoln Lindseth Professor in Biomedical Engineering, Department of Biomedical EngineeringProfessor, Department of Neurosciences, School of MedicineProfessor, Department of Physiology and Biophysics, School of MedicineEmail: dominique.durand@case.edu
Phone: 216.368.3974
My research is in computational neuroscience, electrophysiology, and signaling networks in hippocampus.
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Serpil C. Erzurum, MD
Chair, Lerner Research InstituteEmail: serpil.erzurum@case.edu
Our lab focuses on mechanisms that initiate and perpetuate lung inflammation and remodeling, in addition to lung diseases such as asthma and pulmonary vascular disease.