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W. Henry Boom, MD
Professor, Department of Molecular Biology and Microbiology, School of MedicineChief, Division of Infectious Diseases & HIV Medicine, School of MedicineDirector, Tuberculosis Research Unit, School of MedicineEmail: whb@case.edu
Phone: 216.368.1949
My research is in tuberculosis, cytokines, antigen processing, anti-microbial immunity, HIV-1, and pulmonary host defense.
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Walter F. Boron, MD, PhD
Distinguished University ProfessorChairman, Department of Physiology and BiophysicsEmail: walter.boron@case.edu
Phone: 216.368.8978
My areas of investigation include acid-base homeostasis and gas channels.
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Susann M. Brady-Kalnay, PhD
Sally S. Morley Designated Professor of Brain Tumor Research, School of MedicineProfessor, Department of Molecular Biology and Microbiology, School of MedicineProfessor, Department of Neurosciences, School of MedicineProfessor, Department of Pathology, School of MedicineProfessor, Division of General Medical Sciences - OncologyMember, Cancer Imaging Program, Case Comprehensive Cancer CenterMember, CWRU Center for Imaging ResearchEmail: susann.brady-kalnay@case.edu
Phone: 216-368-0330
I research receptor protein tyrosine phosphatases, cell adhesion, and signal transduction, as well as PTPs in adherens junctions and desmosomes.
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Heather Broihier, PhD
Professor, Department of Neurosciences, School of MedicineDirector, Neurosciences PhD Program, School of MedicineDeputy Director, Medical Scientist Training Program, School of MedicineEmail: Heather.Broihier@case.edu
Our lab studies synapse assembly and disassembly. We take molecular genetic approaches in Drosophila to define the functions of evolutionarily-conserved signaling pathways in circuit formation and function. We take an integrated approach using conditional genetics, live imaging, high resolution microscopy, electrophysiology, and behavioral assays.
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Douglas Brubaker, PhD
Assistant Professor, Department of Pathology, Center for Global Health and Diseases, School of MedicineAssistant Professor, Department of Biomedical Engineering, School of MedicineMember, Developmental Therapeutics Program, Case Comprehensive Cancer CenterCore Member, University Hospitals Case Medical Center, Blood, Heart, Lung and Immunology Research Center, School of MedicineEmail: dkb50@case.edu
The Brubaker Lab develops systems biology approaches to model host-microbiome interactions and identify novel therapeutic strategies for complex inflammatory diseases.
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Stacy Brubaker, MSN, MN, RN, CNP
Email: sab159@case.edu
Phone: 216.368.8896
Our lab develops computational approaches for host and microbiome data integration and modeling with the goal of discovering the biological and engineering principles by which cellular systems function. We work in multiple physiological contexts (e.g. gut, joint, reproductive tract) and emphasize computational models of human clinical data together with experimental validation of model results. We are also highly interested in the challenged of translating data from preclinical experimental systems to human physiological contexts through experimental and computational systems biology.
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Anna Bruchez, PhD
Assistant Professor, Department of Pathology, School of MedicineEmail: axb1108@case.edu
The Bruchez lab uses unbiased forward genetic screening in human and other mammalian cells to identify novel cellular pathways that affect virus infection. The lab studies emerging viral pathogens, focusing on RNA viruses such as Ebolavirus and Coronaviruses. These high-throughput screening approaches identify novel host-virus interactions that interfere with viral replication, and have uncovered innate immune mechanisms that cells use to resist infection by these viruses. We harness a variety of model viruses, cells, and native SARS-CoV-2 in BSL3 containment, to reveal insights into virus-host interactions and the fundamental cell biology of viral infection.
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David Buchner, PhD
Associate Professor, Department of Genetics and Genome Sciences, School of MedicineEmail: david.buchner@case.edu
Phone: 216.368.1816
Our lab is interested in identifying genes that underlie endocrine disorders ranging from rare monogenic diseases to complex polygenic traits. We also seek to understand the cellular mechanisms underlying these disorders, with a particular focus on insulin signaling and glucose regulation in adipocytes.
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Matthias Buck, PhD
Professor, Department of Physiology and Biophysics, School of MedicineAssociate Professor, Department of Pharmacology, School of MedicineAssistant Professor, Department of Neurosciences, School of MedicineMember, Molecular Oncology Program, Case Comprehensive Cancer CenterEmail: mxb150@case.edu
Phone: 216.368.8651
I focus in structure/dynamics of protein complexes involved in cancer, neurodegeneration and in cardiovascular development. My research is also in molecular mechanism of plexin, Eph transmembrane receptors and small GTPases in cell motility.
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Aaron Burberry, PhD
Assistant Professor, Department of Pathology, School of MedicineMember, Immune Oncology Program, Case Comprehensive Cancer CenterEmail: aaron.burberry@case.edu
Phone: 216.368.1066
Neurodegenerative diseases impart a devastating toll on patients and their caregivers, while costing hundreds of billions in lost wages and healthcare annually. Rare genetic mutations and common genetic polymorphisms interact in surprising ways with the environment to shape each person’s relative risk of developing disease. Our research leverages patient biomaterial, human pluripotent stem cells and animal models to discover disease relevant pathways to ultimately enable innovative therapeutic strategies.