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Walter F. Boron, MD, PhD
Distinguished University ProfessorChairmanDepartment of Physiology and BiophysicsEmail: walter.boron@case.edu
Phone: 216.368.8978
My areas of investigation include acid-base homeostasis and gas channels.
Susann M. Brady-Kalnay, PhD
Sally S. Morley Designated Professor of Brain Tumor ResearchSchool of MedicineProfessorDepartment of Molecular Biology and MicrobiologySchool of MedicineProfessorDepartment of NeurosciencesSchool of MedicineProfessorDepartment of PathologySchool of MedicineProfessorDivision of General Medical Sciences - OncologyMemberCancer Imaging ProgramCase Comprehensive Cancer CenterEmail: susann.brady-kalnay@case.edu
Phone: 216-368-0330
I research receptor protein tyrosine phosphatases, cell adhesion, and signal transduction, as well as PTPs in adherens junctions and desmosomes.
Heather Broihier, PhD
ProfessorDepartment of NeurosciencesSchool of MedicineDirectorNeurosciences PhD ProgramSchool of MedicineDeputy DirectorMedical Scientist Training ProgramSchool of MedicineEmail: Heather.Broihier@case.edu
Our lab studies synapse assembly and disassembly. We take molecular genetic approaches in Drosophila to define the functions of evolutionarily-conserved signaling pathways in circuit formation and function. We take an integrated approach using conditional genetics, live imaging, high resolution microscopy, electrophysiology, and behavioral assays.
Douglas Brubaker, PhD
Assistant ProfessorDepartment of PathologyCenter for Global Health and DiseasesSchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: dkb50@case.edu
The Brubaker Lab develops systems biology approaches to model host-microbiome interactions and identify novel therapeutic strategies for complex inflammatory diseases.
Stacy Brubaker, MSN, MN, RN, CNP
Email: sab159@case.edu
Phone: 216.368.8896
Our lab develops computational approaches for host and microbiome data integration and modeling with the goal of discovering the biological and engineering principles by which cellular systems function. We work in multiple physiological contexts (e.g. gut, joint, reproductive tract) and emphasize computational models of human clinical data together with experimental validation of model results. We are also highly interested in the challenged of translating data from preclinical experimental systems to human physiological contexts through experimental and computational systems biology.
Anna Bruchez, PhD
Assistant ProfessorDepartment of PathologySchool of MedicineEmail: axb1108@case.edu
The Bruchez lab uses unbiased forward genetic screening in human and other mammalian cells to identify novel cellular pathways that affect virus infection. The lab studies emerging viral pathogens, focusing on RNA viruses such as Ebolavirus and Coronaviruses. These high-throughput screening approaches identify novel host-virus interactions that interfere with viral replication, and have uncovered innate immune mechanisms that cells use to resist infection by these viruses. We harness a variety of model viruses, cells, and native SARS-CoV-2 in BSL3 containment, to reveal insights into virus-host interactions and the fundamental cell biology of viral infection.
David Buchner, PhD
Associate ProfessorDepartment of Genetics and Genome SciencesSchool of MedicineEmail: david.buchner@case.edu
Phone: 216.368.1816
Our lab is interested in identifying genes that underlie endocrine disorders ranging from rare monogenic diseases to complex polygenic traits. We also seek to understand the cellular mechanisms underlying these disorders, with a particular focus on insulin signaling and glucose regulation in adipocytes.
Matthias Buck, PhD
ProfessorDepartment of Physiology and BiophysicsSchool of MedicineAssociate ProfessorDepartment of PharmacologySchool of MedicineAssistant ProfessorDepartment of NeurosciencesSchool of MedicineMemberMolecular Oncology ProgramCase Comprehensive Cancer CenterEmail: mxb150@case.edu
Phone: 216.368.8651
I focus in structure/dynamics of protein complexes involved in cancer, neurodegeneration and in cardiovascular development. My research is also in molecular mechanism of plexin, Eph transmembrane receptors and small GTPases in cell motility.
Aaron Burberry, PhD
Assistant ProfessorDepartment of PathologySchool of MedicineMemberImmune Oncology ProgramCase Comprehensive Cancer CenterEmail: aaron.burberry@case.edu
Phone: 216.368.1066
Neurodegenerative diseases impart a devastating toll on patients and their caregivers, while costing hundreds of billions in lost wages and healthcare annually. Rare genetic mutations and common genetic polymorphisms interact in surprising ways with the environment to shape each person’s relative risk of developing disease. Our research leverages patient biomaterial, human pluripotent stem cells and animal models to discover disease relevant pathways to ultimately enable innovative therapeutic strategies.
Adam Burgener, PhD
ProfessorDepartment of PathologySchool of MedicineDirectorCenter for Global Health and DiseasesSchool of MedicineMemberPopulation and Cancer Prevention ProgramCase Comprehensive Cancer CenterAdel Mahmoud Professorship of Global Health and VaccinesEmail: axb1160@case.edu
Phone: 216.368.2072
Our laboratory specializes in mass spectrometry based proteomics and systems biology to study host immunity, the microbiome, and interactions in disease. A central focus of our research has been to study host and microbial factors at mucosal surfaces that underlie susceptibility to infectious disease and cancer.