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Paul L. Fox, PhD
ProfessorDepartment of Molecular MedicineSchool of MedicineMemberMolecular Oncology ProgramCase Comprehensive Cancer CenterEmail: foxp@ccf.org
Phone: 216.444.8053
I study the regulation of Endothelial cell motility, the role of Ceruloplasmin in inflammation and Atherosclerosis, and iron homeostasis.
Michael Freeman, PhD
Assistant ProfessorDivision of Infectious Diseases & HIV MedicineCenter for AIDS ResearchSchool of MedicineEmail: mlf62@case.edu
Phone: 216.368.1260
Our lab investigates the mechanisms of immunity and immunopathogenesis during infections, aging, and inflammatory disorders in humans. We use cellular immunology techniques such as flow cytometry of clinical samples and in vitro cultures to better understand how pathogens and chronic inflammation contribute to the activation, expansion, maintenance, and trafficking of T cells and monocytes and how these cells contribute to infection-associated immunopathology and comorbidities in people living with HIV.
David Friel, PhD
Associate ProfessorDepartment of NeurosciencesSchool of MedicineEmail: david.friel@case.edu
Phone: 216.368.4930
I primarily focus on calcium homeostasis, electrophysiology, ion channels, modulation, optical methods for measuring Ca2+, and modeling.
Yuan Gao, PhD
Assistant ProfessorDepartment of PharmacologySchool of MedicineMemberCancer Genomics and Epigenomics ProgramCase Comprehensive Cancer CenterEmail: yxg811@case.edu
Phone: 216.368.6632
The primary research objective in our lab is to uncover novel fundamental mechanisms underlying gene expression in cancers. We employ a range of advanced multi-omics technologies to comprehensively detail the oncogenic mechanisms of transcription factors and identify therapeutic targets for treatment.
Jeffrey L. Garvin, PhD
ProfessorDepartment of Physiology and BiophysicsEmail: jeffrey.garvin@case.edu
Phone: 216.368.3353
My research areas include regulation of renal ion transport, hemodynamics and cell signaling, and their roles in blood pressure control. In particular we are now investigating how dietary fructose changes kidney metabolism and thuis ion trasport in the proximal nephron and how the mechanical stimulus of urine flow is transduced into chemical signals that ultimately alter Na reabsorption in thick ascending limbs.
Leah A. Gates, PhD
Assistant ProfessorDepartment of BiochemistrySchool of MedicineMemberCancer Genomics and Epigenomics ProgramCase Comprehensive Cancer CenterEmail: leah.gates@case.edu
Phone: 216-368-5572
We study the intersection between metabolism, chromatin, and gene regulation. We aim to discover how metabolite signaling to chromatin impacts cell and tissue function in health and disease, with a particular focus on the intestine. We use biochemical techniques, cell culture and organoid systems, and animal models to carry out our research.
Thomas A. Gerken , PhD
ProfessorDepartment of BiochemistrySchool of MedicineProfessorDepartment of PediatricsSchool of MedicineMemberPopulation and Cancer Prevention ProgramCase Comprehensive Cancer CenterEmail: thomas.gerken@case.edu
Phone: 216.368.4556
Mucin type O-glycosylation is an essential post translational protein modification linked to multiple disease states including many cancers and is critical to development. Our lab studies the control of mucin type O-glycosylation at the transferase and peptide acceptor substrate level. We utilize enzyme activity/kinetics and structural biological approaches to deduce how the initiating glycosyltransferases select and recognize specific sites to glycosylate in protein substrates.
Stanton L. Gerson, MD
DeanSchool of MedicineSenior Vice President for Medical AffairsDirectorNational Center for Regenerative MedicineProfessorDepartment of MedicineProfessorDepartment of Environmental Health SciencesMemberImmune Oncology ProgramCase Comprehensive Cancer CenterEmail: stanton.gerson@case.edu
Phone: 216.368.2825
We investigate transgenic mice and carcinogenesis, retroviral gene therapy, DNA repair, hematopoietic stem cells, and adipogenesis.
Mahmoud Ghannoum, PhD
ProfessorDepartment of DermatologySchool of MedicineProfessorDepartment of PathologySchool of MedicineMemberMolecular Oncology ProgramCase Comprehensive Cancer CenterEmail: mahmoud.ghannoum@case.edu
Phone: 216.844.8580
My lab investigates fungal pathogens including Candida, Aspergillus and Cryptococcus, in addition to fungal virulence factors including phospholipase B, germination, adhesion, and biofilm formation.
Marcin Golczak, PhD
Associate ProfessorDepartment of PharmacologySchool of MedicineMemberCleveland Center for Membrane & Structural BiologyEmail: mxg149@case.edu
Phone: 216.368.0302
I research the physiology of vision at the molecular level and lipid metabolism and homeostasis in the eye. I also design therapeutic strategies against age-related retinal degeneration and dry eye syndrome.