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Neetu Gupta, PhD
Associate ProfessorDepartment of Molecular MedicineSchool of MedicineMemberImmune Oncology ProgramCase Comprehensive Cancer CenterEmail: guptan@ccf.org
Phone: 216.444.7455
I focus on molecular mechanisms regulating antibody-mediated immunity to infections and B cell lymphoma pathogenesis.
Sanjay Gupta, PhD, MS
Carter Kissell Professor and Research DirectorDepartment of UrologySchool of MedicineAssociate ProfessorDepartment of NutritionSchool of MedicineMemberPopulation and Cancer Prevention ProgramCase Comprehensive Cancer CenterEmail: sanjay.gupta@case.edu
Phone: 216.368.6162
I research biomarkers for early detection and prognosis of prostate cancer, molecular targets for prevention and treatment of prostate cancer, and epigenetic mechanisms of gene silencing.
Jonathan L. Haines, PhD
ChairDepartment of Population and Quantitative Health SciencesSchool of MedicineMary W. Sheldon MD Professor of Genomic SciencesDepartment of Population and Quantitative Health SciencesSchool of MedicineProfessorDepartment of Genetics and Genome SciencesSchool of MedicineProfessorDepartment of Ophthalmology and Visual SciencesSchool of MedicineFounder and DirectorCleveland Institute for Computational BiologySchool of MedicineEmail: jonathan.haines@case.edu
Phone: 216.368.0411
My focus is on genetic epidemiology of neurological and opthalmological disorders, as well as computational methods for biomedical big data.
Xiaonan Han, PhD
Associate ProfessorDepartment of MedicineSchool of MedicineMemberCancer Genomics and Epigenomics ProgramCase Comprehensive Cancer CenterEmail: xxh455@case.edu
Our laboratory is interested in the chronic infection- or inflammation-induced colorectal cancer (CRC), which can cause the majority of metastatic CRC (CRC) over time without intervention. One of the most important pathogeneses of mCRC is cancer stem cell (CSC) malignancy induced by somatic mutations. Using murine and human adult stem cell- and human induced pluripotent stem cell (IPSC)-derived tumoroids, our laboratory comprehensively tests the genetic and epigenetic mechanisms of CSC malignancy during loss of anti-proinflammatory TH2 cytokine-JAKs-STAT5 signaling, further determine the targets of intervention of CSC-induced mCRC.
Philippe Haouzi, MD
ResearcherDepartment of NeurosciencesLerner Research Institute, Cleveland ClinicSchool of Medicine- Regulation of respiration and blood gas homeostasis. In vivo studies in small and large mammals, neural mechanisms of control of respiration
- toxicology: Development of countermeasures against mitochondrial poisons
- Opioid overdose
Clifford V. Harding, MD, PhD
Joseph R. Kahn Professor and Chair of PathologyDepartment of PathologySchool of MedicineProfessorDepartment of AnatomySchool of MedicineProfessorDepartment of MedicineSchool of MedicineMemberImmune Oncology ProgramCase Comprehensive Cancer CenterUniversity Hospitals Distinguished PhysicianUniversity Hospitals Cleveland Medical CenterEmail: cvh3@case.edu
Phone: 216.368.3611
My areas of research include immunology, MHC, antigen processing, T cell, phagocytosis, endocytosis, subcellular fractionation, mycobacteria, tumor immunity, tuberculosis, cell biology, exosomes, and extracellular vesicles.
Ann Harris, PhD
Vice Chair of ResearchDepartment of Genetics and Genome SciencesSchool of MedicineProfessorDepartment of Genetics and Genome SciencesSchool of MedicineMemberCancer Genomics and Epigenomics ProgramCase Comprehensive Cancer CenterEmail: ann.harris@case.edu
Phone: 216.368.6651
I research tissue-specific and temporal regulation of gene expression in health and disease. In addition, I study functional genomics of regulatory elements, transcriptional networks, and Chromatin architecture.
Peter J. Harte, PhD
ProfessorDepartment of Genetics and Genome SciencesSchool of MedicineMemberCancer Genomics and Epigenomics ProgramCase Comprehensive Cancer CenterEmail: peter.harte@case.edu
Phone: 216.368.6417
My focus is in transcription activation, repression, Chromatin structure, and homeotic genes.
Stanley L. Hazen, MD, PhD
ChairmanLerner Research InstituteMemberMolecular Oncology ProgramCase Comprehensive Cancer CenterI research the role of gut microbiome in cardiometaboilc diseases and oxidative pathways in inflammation and cardiovascular disease.
Christopher Hine, PhD
Assistant ProfessorDepartment of Molecular MedicineSchool of MedicineMemberMolecular Oncology ProgramCase Comprehensive Cancer CenterEmail: hinec@ccf.org
The research performed in the Hine lab is focused on nutritional, environmental, and genetic factors impacting aging and longevity. To this end, we use in vivo, cellular, and in vitro model systems to understand the hormonal and nutritional regulation of endogenous hydrogen sulfide (H2S) metabolism to cultivate clinically applicable interventions to harness endogenous H2S production for beneficial health outcomes such as increased stress resistance, metabolic fitness, cognition, and lifespan.