Professor Emeritus
Department of Nutrition
School of Medicine
Professor
Department of Biochemistry
School of Medicine
Member
Cancer Genomics and Epigenomics Program
Case Comprehensive Cancer Center
For the past 50 years I worked on the metabolic regulation of organs and cells in health and disease, using biochemical, isotopic and metabolomic techniques.
Teaching Information
Teaching Interests
one-one one mentoring in metabolic (dys)regulation
Teaching Schedule
- Fall 2010: Metabolic regulation of perfused organs
- Faculty in Annual NIDDK-sponsored course in "Use of isotopic techniques for metabolic research" (for 13 years)
Office Hours
By appointment
Research Information
Research Interests
Dr. Brunengraber's research concentrates on metabolic regulation investigated in isolated cells and perfused organs by a combination of metabolomics and stable isotopic technologies based on mass spectrometry. This combination allows the discovery of new metabolic pathways and new regulatory mechanisms. It was with these techniques that, in 1994, his lab discovered what is now called the reductive metabolism of glutamine. This process plays an important role in the metabolism of cancer cells.
Research Projects
- Metabolic regulation of pancreatic cancer
- Pathobiochemistry of retinopathy of prematurity
- Pathobiochemistry of macular degeneration
- Preservation of perfused limbs in preparation to transplantation
- Nephropathy of diabetes
Recent Funding
- Co-Investigator in 2 NIH grants (5 and 4 years, starting 07/2021) to Dr Bela Anand-Apte, Dept of Ophthalmology, Lerner Research Institute, Cleveland Clinic
- Co-investigator in new NIH grant (5 years starting 07/2021) to Dr Jeffrey Schelling Dept Medicine CWRU
Awards and Honors
Established Investigator
1978
American Heart Association
Future Leader in Nutrition Award
1979
Nutrition Foundation, New York
Endowed Mt. Sinai Auxiliary Chair in Nutrition Research
2003
Case Western Reserve University
Publications
Education
Master of Science
Chemistry
University of Liege, Belgium
1961
Doctor of Medicine
Free University of Brussels
1968
Doctor of Philosophy
Biochemistry
Free University of Brussels
1977
Residency
Clinical Biochemistry
Free University of Brussels
1976
Residencies, Internships and Fellowships
Residency in Clinical Biochemistry
Free University of Brussels
1976
Postdoctoral Training in Biochemistry
Brandeis University
1971