About Us

The Center for Proteomics and Bioinformatics features:

  • 8,000 sq. ft. of laboratory space
  • Advanced mass spectrometry instrumentation
  • Wet lab biochemistry facilities
  • State-of-the-art computational equipment
  • A conference room equipped with a Life Size videoconferencing unit (max. capacity 40)
  • Regular seminars and workshops

The Case Center for Proteomics and Bioinformatics was created, in part, to strengthen Cleveland's presence in modern proteomics and bioinformatics research to make the region a leader in the field. The vision for the Center has been shaped over the past several years by the leadership of the Center’s Director, Mark Chance, Ph.D., with over $60 million in grants awarded to the Center and its collaborators since its inception in February 2006. One of the primary goals of the CPB is to develop an infrastructure of sophisticated equipment that facilitates and maximizes shared equipment usage, as well as to offer a wide array of proteomics and bioinformatics services including, mass spectrometry, protein expression/interactions, systems biology, and biostatistical analyses.

Proteomics entails the in depth structural analysis of individual proteins in human and animal cells. In studying proteins and their changes, bioinformatics enables researchers to take an integrated -omics approach for discovering networks involved in human disease. The School of Medicine has established the Center for Proteomics and Bioinformatics to perform research to better understand the genetic and environmental bases of disease as well as provide new technologies to diagnose diseases such as cancer, heart disease, and diabetes.

New technologies in mass spectrometry are also allowing protein expression, localization, structure, post-translational modifications, and interactions to be studied in increasing detail and on a genome wide scale. The Center is also developing and applying state-of-the-art-structural proteomics technologies to understand the function and interactions of macromolecular complexes.