My research interests focus on two overall themes:
- Integration of multiple structural biological techniques to develop a comprehensive understanding of functional macromolecular complexes.
- Development of instrumentation to improve the tools available for such studies.
Techniques of interest include:
- Synchrotron protein footprinting
- X-ray absorption
- Small-angle x-ray scattering
- Cryo-electron microscopy
- X-ray crystallography
- Infrared microspectroscopy
- Biochemical kinetic studies of enzymes and computational modeling
I am currently the on-site lead in the effort to develop a world-leading program in x-ray footprinting at the NSF-CWRU funded beamline XFP (X-ray Footprinting for In Vitro and In Vivo Structural Studies of Biological Macromolecules) currently being constructed at NSLS-II. I am also involved in development of detectors, including x-ray beam imaging diagnostics as well as ion beam diagnostics; we are also currently exploring the application of these technologies to therapeutic dosimetry.