Jen Bohon, PhD

Research Information

Research Interests

My research interests focus on two overall themes:

  • Integration of multiple structural biological techniques to develop a comprehensive understanding of functional macromolecular complexes.
  • Development of instrumentation to improve the tools available for such studies.

Techniques of interest include:

  • Synchrotron protein footprinting
  • X-ray absorption
  • Spectroscopy
  • Small-angle x-ray scattering
  • Cryo-electron microscopy
  • X-ray crystallography
  • Infrared microspectroscopy
  • Biochemical kinetic studies of enzymes and computational modeling

Research Projects

I am currently the on-site lead in the effort to develop a world-leading program in x-ray footprinting at the NSF-CWRU funded beamline XFP (X-ray Footprinting for In Vitro and In Vivo Structural Studies of Biological Macromolecules) currently being constructed at NSLS-II. I am also involved in development of detectors, including x-ray beam imaging diagnostics as well as ion beam diagnostics; we are also currently exploring the application of these technologies to therapeutic dosimetry.