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Mei Zhang, PhD
Assistant Professor, Department of Biomedical EngineeringMember, Immune Oncology Program, Case Comprehensive Cancer CenterMember, CWRU Center for Imaging ResearchEmail: mei.zhang2@case.edu
Phone: 216-368-6744
We are interested in applying multi-omic analysis (metabolomics, proteomics, and lipidomics) to understand host-microbe interactions and use this knowledge to develop immunotherapies for cancer and autoimmune diseases. Our study involves system immunology, computational biology, oncology, and microbiology.
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Yi Zhang, PhD
Assistant Professor, Department of Biochemistry, School of MedicineMember, Cleveland Center for Membrane & Structural BiologyMember, Molecular Oncology Program, Case Comprehensive Cancer CenterEmail: yi.zhang26@case.edu
Phone: 216.368.0424
Our research investigates topics at the interface of chemistry and biology, focusing on elucidating the molecular basis of cellular pathways important for human health and disease biology. We employ integrative approaches to study the structure and behavior of macromolecules, understand their functions, and then predict and validate their roles in different cellular contexts. Current research areas include selective autophagy, chromatin biology and epigenetics, and biomolecular condensates.
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You-Wei Zhang, PhD
Adjunct Professor, Department of Pharmacology, School of MedicineAdjunct Professor, Department of Genetics and Genome Sciences, School of MedicineEmail: yxz169@case.edu
My research focuses on molecular mechanisms regulating genome stability and their potential application in cancer therapy.
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Chen Zhao, MD, PhD
Associate Professor, Department of Pathology, School of MedicineMember, Immune Oncology Program, Case Comprehensive Cancer CenterEmail: cxz545@case.edu
Phone: 216.368.4712
We are focusing on seeking in-depth understanding of the mechanisms of hematopoietic stem/progenitor cell (HSPC) self-renewal, the interactions of HSPCs and bone marrow microenvironment, and how these become dysregulated to cause leukemia/lymphoma. Specifically, we are focusing on 1) How HSF1 specifically regulates AML stem cells; and 2) how B-myeloid conversion is regulated in a pathological context.
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Qing Yin Zheng, PhD
Associate Professor, Department of Otolaryngology, School of MedicineAssociate Professor, Department of Genetics and Genome Sciences, School of MedicineEmail: qing.zheng@case.edu
Phone: 216.844.3441
I research the genes and molecular pathways involved in mouse models of human deafness, including Otitis Media and Usher syndrome.
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Lan Zhou, MD, PhD
Adjunct Professor, Department of Pathology, School of MedicineMember, Immune Oncology Program, Case Comprehensive Cancer CenterEmail: lan.zhou@case.edu
Phone: 216.368.1671
My labs studies Notch signaling in stress hematopoiesis, hematopoietic stem cell niche, and leukemia microenvironment. Additional projects include pathogenesis of inflammation-associated colorectal cancer mouse models and targeting pancreatic cancer metabolic vulnerability and drug resistance.
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Xiongwei Zhu, PhD
Professor, Department of Pathology, School of MedicineProfessor, Department of Neurology, School of MedicineCo-Director, Pathology Graduate Program, Department of Pathology, School of MedicineDirector, Molecular and Cellular Basis for Disease Training Program, Department of Pathology, School of MedicineEmail: xiongwei.zhu@case.edu
Phone: 216.368.5903
My lab studies pathogenic mechanisms underlying neurodegeneration in age-related neurodegenerative diseases including Alzheimer's disease and Parkinson disease with a focus on mitochondrial dysfunction and oxidative stress. A variety of experimental systems are used, including primary and transformed neuronal cells and multiple mouse models representing these disorders as well as brain tissues from human patients.
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Xiaofeng Zhu, PhD
Professor, Department of Population and Quantitative Health Sciences, School of MedicineFaculty, Cleveland Institute for Computational BiologyEmail: xxz10@case.edu
Phone: 216.368.0201
We are focused on developing statistical and deep learning methods, along with software and bioinformatic tools, for analyzing genetic and genomic data. Additionally, we aim to understand the biological mechanisms underlying various disease phenotypes, including cardiovascular disease, hypertension, obesity, sleep disorders, and Alzheimer's Disease.
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Shiwei Zhu, PhD
Assistant Professor, Department of Physiology and Biophysics, School of MedicineEmail: shiwei.zhu@case.edu
Phone: 216.368.3400
We are interested in utilizing an advancing imaging technique, cryo-electron tomography, to visualize antimicrobial protein complexes directly in their native cellular context. We also employ cryo-EM single particle analysis and other biophysical techniques to study the structure and mechanism of antimicrobial macromolecular complexes. We aim to provide essential structural information to help develop strategies to combat infectious diseases.
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Richard Zigmond, PhD
Professor, Department of Neurosciences, School of MedicineProfessor, Department of Neurological Surgery, School of MedicineProfessor, Department of Pathology, School of MedicineEmail: Richard.Zigmond@case.edu
Phone: 216.368.4614
I focus on changes in neuronal gene expression after injury and their relationship to nerve regeneration. I study the role of immune cells in nerve degeneration and regeneration, and compare nerve regeneration in different types of sensory neurons.