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Congrong "Ron" Yu, PhD
ChairDepartment of NeurosciencesSchool of MedicineTilles-Weidenthal Professorship in Parkinson’s Disease and Movement Disorders ResearchDepartment of NeurosciencesSchool of MedicineEmail: Ron.Yu@case.edu
Phone: 216.368.5159
Edward Yu, PhD
ProfessorDepartment of PharmacologySchool of MedicineMemberCleveland Center for Membrane & Structural BiologyEmail: ewy5@case.edu
Phone: 216.368.5358
I investigate the structural biology of multidrug resistance trasnporters and bacterial metabolite transporters.
Yi Zhang, PhD
Assistant ProfessorDepartment of BiochemistrySchool of MedicineMemberCleveland Center for Membrane & Structural BiologyMemberMolecular Oncology ProgramCase Comprehensive Cancer CenterEmail: yi.zhang26@case.edu
Phone: 216.368.0424
Our research investigates topics at the interface of chemistry and biology, focusing on elucidating the molecular basis of cellular pathways important for human health and disease biology. We employ integrative approaches to study the structure and behavior of macromolecules, understand their functions, and then predict and validate their roles in different cellular contexts. Current research areas include selective autophagy, chromatin biology and epigenetics, and biomolecular condensates.
Mei Zhang, PhD
Assistant ProfessorDepartment of Biomedical EngineeringCase School of EngineeringSchool of MedicineMemberImmune Oncology ProgramCase Comprehensive Cancer CenterMemberCWRU Center for Imaging ResearchEmail: mei.zhang2@case.edu
Phone: 216-368-6744
We are interested in applying multi-omic analysis (metabolomics, proteomics, and lipidomics) to understand host-microbe interactions and use this knowledge to develop immunotherapies for cancer and autoimmune diseases. Our study involves system immunology, computational biology, oncology, and microbiology.
Peng Zhang, PhD
Assistant ProfessorDepartment of NeurosciencesSchool of MedicineEmail: Peng.Zhang13@case.edu
Phone: 216.368.2064
Our laboratory combines molecular, cellular, and electrophysiological approaches with state-of-art Expansion Microscopy and 3D electron microscopy in the cultured neuron and transgenic mouse models to analyze how neurons establish their communications through a specialized unit termed “synapse”. We are particularly interested in an interdisciplinary study about the role of extracellular polysaccharide in regulating the structure and function of synapses. Elucidating these mechanisms is important for understanding how synapses develop in health and how they dysfunction in neurodevelopmental and neurodegenerative disorders.
You-Wei Zhang, PhD
ProfessorDepartment of PharmacologySchool of MedicineChairDepartment of PharmacologyGraduate Qualification CommitteeVice ChairmanCommittee for Biomedical ResearchSchool of MedicineDirectorSOM Graduate Program C3MB Cell Biology CourseSchool of MedicineMemberMolecular Oncology ProgramCase Comprehensive Cancer CenterProfessorDepartment of Genetics and Genome SciencesSchool of MedicineEmail: yxz169@case.edu
Phone: 216.368.7588
My research focuses on molecular mechanisms regulating genome stability and their potential application in cancer therapy.
Chen Zhao, MD, PhD
Associate ProfessorDepartment of PathologySchool of MedicineMemberImmune Oncology ProgramCase Comprehensive Cancer CenterEmail: cxz545@case.edu
Phone: 216.368.4712
We are focusing on seeking in-depth understanding of the mechanisms of hematopoietic stem/progenitor cell (HSPC) self-renewal, the interactions of HSPCs and bone marrow microenvironment, and how these become dysregulated to cause leukemia/lymphoma. Specifically, we are focusing on 1) How HSF1 specifically regulates AML stem cells; and 2) how B-myeloid conversion is regulated in a pathological context.
Qing Yin Zheng, PhD
Associate ProfessorDepartment of OtolaryngologySchool of MedicineAssociate ProfessorDepartment of Genetics and Genome SciencesSchool of MedicineEmail: qing.zheng@case.edu
Phone: 216.844.3441
I research the genes and molecular pathways involved in mouse models of human deafness, including Otitis Media and Usher syndrome.
Lan Zhou, MD, PhD
Adjunct ProfessorDepartment of PathologySchool of MedicineMemberImmune Oncology ProgramCase Comprehensive Cancer CenterEmail: lan.zhou@case.edu
Phone: 216.368.1671
My labs studies Notch signaling in stress hematopoiesis, hematopoietic stem cell niche, and leukemia microenvironment. Additional projects include pathogenesis of inflammation-associated colorectal cancer mouse models and targeting pancreatic cancer metabolic vulnerability and drug resistance.
Xiongwei Zhu, PhD
ProfessorDepartment of PathologySchool of MedicineProfessorDepartment of NeurologySchool of MedicineCo-Director, Pathology Graduate ProgramDepartment of PathologySchool of MedicineDirector, Molecular and Cellular Basis for Disease Training ProgramDepartment of PathologySchool of MedicineEmail: xiongwei.zhu@case.edu
Phone: 216.368.5903
My lab studies pathogenic mechanisms underlying neurodegeneration in age-related neurodegenerative diseases including Alzheimer's disease and Parkinson disease with a focus on mitochondrial dysfunction and oxidative stress. A variety of experimental systems are used, including primary and transformed neuronal cells and multiple mouse models representing these disorders as well as brain tissues from human patients.