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Stephanie Langel, PhD
Assistant Professor, Department of Pathology, School of MedicineMember, Center for Global Health and Diseases, School of MedicineEmail: sxl2057@case.edu
Phone: 216.368.0514
The Langel lab is focused on understanding antibody and B cell responses to viral infections, particularly during pregnancy and lactation. To accomplish this, the Langel lab is using single cell technologies, translational animal models, and human clinical samples. The Langel lab's overall goal is to improve maternal and neonatal health around the world.
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Justin D. Lathia, PhD
Scientific Director, Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine of Case Western Reserve UniversityCo-Leader, Molecular Oncology Program, Case Comprehensive Cancer CenterProfessor, Department of Molecular Medicine, Cleveland Clinic Lerner College of MedicineDirector of Faculty Development, Cleveland Clinic ResearchProfessor, Department of Cancer Sciences, Cleveland Clinic ResearchEmail: lathiaj@ccf.org
Phone: 216.445.7475
We use in vivo imaging models to interrogate the tumor microenvironment, examining communication mechanisms in cancer stem cells, currently focused on malignant brain tumors.
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John J. Letterio, MD
Professor, Department of Pediatrics, School of MedicineCo-Leader, Developmental Therapeutics Program, Case Comprehensive Cancer CenterDivision Chief, Pediatric Oncology, University HospitalsEmail: john.letterio@UHhospitals.org
Phone: 216.844.3345
I focus on TGF-ß in immune cell development and function, as well as tumor suppressor functions of TGF-b.
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Alan Levine, PhD
Professor, Department of Molecular Biology and Microbiology, School of MedicineProfessor, Department of PharmacologyProfessor, Department of Medicine, School of MedicineProfessor, Department of Pathology, School of MedicineProfessor, Department of Pediatrics, School of MedicineEmail: alan.levine@case.edu
Phone: 216.368.0342
My research includes intestinal host defense: immune tolerance and immune protection in inflammatory bowel disease, HIV or SARS-CoV-2 infection, and opioid use disorder.
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Gina Lewin, PhD
Assistant Professor, Department of Pathology, School of MedicineMember, Center for Global Health and Diseases, School of MedicineEmail: grl48@case.edu
Phone: 216.368.1650
Our human microbiota consists of complex communities where microbial interactions modulate bacterial behavior and influence human health. The Lewin lab is interested in understanding the role of microbial interactions in polymicrobial sites, especially the oral microbiome. We use cutting-edge computational techniques and wet-lab approaches to study these interactions in the context microbial diversity and the dynamic infection environment.
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Xiaoxia Li , PhD
Professor, Department of Molecular Medicine, School of MedicineProfessor, Department of Pathology, School of MedicineMember, Immune Oncology Program, Case Comprehensive Cancer CenterEmail: lix@ccf.org
Phone: 216.445.8706
My research includes signal transduction in innate and adaptive immunity.
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Xiao Li, PhD
Associate Professor, Department of Biochemistry, School of MedicineAssociate Professor, Department of Biomedical Engineering, Case School of EngineeringMember, Center for RNA Science and Therapeutics, School of MedicineMember, Population and Cancer Prevention Program, Case Comprehensive Cancer CenterEmail: xiao.li9@case.edu
Phone: 216-368-0258
I study RNA systems biology in precision medicine.
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Yan Li, PhD
Vice Chair of Research, Department of Genetics and Genome SciencesAssociate Professor, Department of Genetics and Genome Sciences, School of MedicineEmail: yan.li17@case.edu
Phone: 216.368.0305
I investigate single cell genomics in diabetes research, non-coding cis-regulatory elements in development and complex diseases, and functional characterization of non-coding GWAS SNPs in diabetic conditions.
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Xin Liu, PhD
Assistant Professor, Department of Biochemistry, School of MedicineEmail: xxl1436@case.edu
Phone: 216-368-2433
My lab is interested in understanding how the immune system responds to a variety of insults (e.g. bacteria, viruses, tumors) to control human diseases (e.g. infectious diseases and cancer). Increasing evidence has implicated that metabolism plays a crucial role in shaping immune cell phenotype and function. Our studies aim to investigate the interactions between metabolism and innate immune response in the settings of lung infection and cancer.
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Tian Liu, PhD
Assistant Professor, Department of Pathology, School of MedicineEmail: txl757@case.edu
Phone: 216.368.4163
My research focuses on the investigations on the role of genetic factors and mitochondria-associated mechanisms in neurodegenerative diseases including Alzheimer’s Disease (AD), Frontotemporal dementia (FTD), and Amyotrophic lateral sclerosis (ALS) using both dry and wet lab multiple approaches. Our goal is to understand mechanistic insights into genetic variants causing the pathogenesis of diseases and to develop translational therapeutic strategies for neurodegenerative disorders.