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Stephanie Langel, PhD
Assistant ProfessorDepartment of PathologySchool of MedicineMemberCenter for Global Health and DiseasesSchool of MedicineEmail: sxl2057@case.edu
Phone: 216.368.0514
The Langel lab is focused on understanding antibody and B cell responses to viral infections, particularly during pregnancy and lactation. To accomplish this, the Langel lab is using single cell technologies, translational animal models, and human clinical samples. The Langel lab's overall goal is to improve maternal and neonatal health around the world.
Justin D. Lathia, PhD
Scientific DirectorRose Ella Burkhardt Brain Tumor and Neuro-Oncology CenterCleveland ClinicCleveland Clinic Lerner College of Medicine of Case Western Reserve UniversityCo-LeaderMolecular Oncology ProgramCase Comprehensive Cancer CenterProfessorDepartment of Molecular MedicineCleveland Clinic Lerner College of MedicineDirector of Faculty DevelopmentCleveland Clinic ResearchProfessorDepartment of Cancer SciencesCleveland Clinic ResearchEmail: lathiaj@ccf.org
Phone: 216.445.7475
We use in vivo imaging models to interrogate the tumor microenvironment, examining communication mechanisms in cancer stem cells, currently focused on malignant brain tumors.
John J. Letterio, MD
ProfessorDepartment of PediatricsSchool of MedicineCo-LeaderDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterDivision ChiefPediatric OncologyUniversity HospitalsEmail: john.letterio@UHhospitals.org
Phone: 216.844.3345
I focus on TGF-ß in immune cell development and function, as well as tumor suppressor functions of TGF-b.
Alan Levine, PhD
ProfessorDepartment of Molecular Biology and MicrobiologySchool of MedicineProfessorDepartment of PharmacologyProfessorDepartment of MedicineSchool of MedicineProfessorDepartment of PathologySchool of MedicineProfessorDepartment of PediatricsSchool of MedicineEmail: alan.levine@case.edu
Phone: 216.368.0342
My research includes intestinal host defense: immune tolerance and immune protection in inflammatory bowel disease, HIV or SARS-CoV-2 infection, and opioid use disorder.
Gina Lewin, PhD
Assistant ProfessorDepartment of PathologySchool of MedicineMemberCenter for Global Health and DiseasesSchool of MedicineEmail: grl48@case.edu
Phone: 216.368.1650
Our human microbiota consists of complex communities where microbial interactions modulate bacterial behavior and influence human health. The Lewin lab is interested in understanding the role of microbial interactions in polymicrobial sites, especially the oral microbiome. We use cutting-edge computational techniques and wet-lab approaches to study these interactions in the context microbial diversity and the dynamic infection environment.
Xiao Li, PhD
Associate ProfessorDepartment of BiochemistrySchool of MedicineAssociate ProfessorDepartment of Biomedical EngineeringCase School of EngineeringMemberCenter for RNA Science and TherapeuticsSchool of MedicineMemberPopulation and Cancer Prevention ProgramCase Comprehensive Cancer CenterEmail: xiao.li9@case.edu
Phone: 216-368-0258
I study RNA systems biology in precision medicine.
Yan Li, PhD
Vice Chair of ResearchDepartment of Genetics and Genome SciencesAssociate ProfessorDepartment of Genetics and Genome SciencesSchool of MedicineEmail: yan.li17@case.edu
Phone: 216.368.0305
I investigate single cell genomics in diabetes research, non-coding cis-regulatory elements in development and complex diseases, and functional characterization of non-coding GWAS SNPs in diabetic conditions.
Xiaoxia Li , PhD
ProfessorDepartment of Molecular MedicineSchool of MedicineProfessorDepartment of PathologySchool of MedicineMemberImmune Oncology ProgramCase Comprehensive Cancer CenterEmail: lix@ccf.org
Phone: 216.445.8706
My research includes signal transduction in innate and adaptive immunity.
Tian Liu, PhD
Assistant ProfessorDepartment of PathologySchool of MedicineEmail: txl757@case.edu
Phone: 216.368.4163
My research focuses on the investigations on the role of genetic factors and mitochondria-associated mechanisms in neurodegenerative diseases including Alzheimer’s Disease (AD), Frontotemporal dementia (FTD), and Amyotrophic lateral sclerosis (ALS) using both dry and wet lab multiple approaches. Our goal is to understand mechanistic insights into genetic variants causing the pathogenesis of diseases and to develop translational therapeutic strategies for neurodegenerative disorders.
Xin Liu, PhD
Assistant ProfessorDepartment of BiochemistrySchool of MedicineEmail: xxl1436@case.edu
Phone: 216-368-2433
My lab is interested in understanding how the immune system responds to a variety of insults (e.g. bacteria, viruses, tumors) to control human diseases (e.g. infectious diseases and cancer). Increasing evidence has implicated that metabolism plays a crucial role in shaping immune cell phenotype and function. Our studies aim to investigate the interactions between metabolism and innate immune response in the settings of lung infection and cancer.