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From Harland Wood's discovery of carbon dioxide fixation to the recent development of the Mighty Mouse by Richard Hanson's group, the Department of Biochemistry has a storied tradition in biomedical research. Faculty in the department use a wide range of techniques and systems to address fundamental biological and disease related questions. Research within the department follows along several tracts.

Structural Biology

Three dimensional structure is the ultimate determinant for protein function and the department has a large contingent of structure related investigators. Technology such as X-ray crystallography, NMR, and Raman spectroscopy are used to decipher the structural properties of a variety of macromolecules.

Paul Carey Marianne Pusztai-Carey
Focco van den Akker Vivien Yee
Thomas Gerken
structural biology

Proteins and Enzymes

Elucidating the biochemical and biophysical properties of individual proteins is essential to understanding how such factors are deregulated in human disease. From metabolic enzymes and chromatin modifying factors to RNA helicases, faculty members study a variety of enzymatic molecules.

Focco van den AkkerVivien Yee
Thomas GerkenWilliam Merrick
Paul Carey Marianne Pusztai-Carey
Proteins and Enzymes

Regulation of Gene Expression

Understanding the molecular mechanisms that control gene expression is a key question in modern biology. Hormonal control of transcription, DNA-protein interactions, and oncogene function are just a few of the topics our faculty are focused on.

Hung-Ying Kao William Merrick
Regulation of Gene Expression
Metabolic Regulation and Gene Therapy