The Bruchez lab uses unbiased forward genetic screening in human and other mammalian cells to identify novel cellular pathways that affect virus infection. The lab studies emerging viral pathogens, focusing on RNA viruses such as Ebolavirus and Coronaviruses. These high-throughput screening approaches identify novel host-virus interactions that interfere with viral replication, and have uncovered innate immune mechanisms that cells use to resist infection by these viruses. We harness a variety of model viruses, cells, and native SARS-CoV-2 in BSL3 containment, to reveal insights into virus-host interactions and the fundamental cell biology of viral infection.
Department of Pathology
School of Medicine