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David T. Lodowski, PhD
Director, Biomedical Sciences Training Program, School of MedicineAssistant Professor, Department of Nutrition, School of MedicineAssistant Professor, Center for Proteomics and Bioinformatics, School of MedicineAssistant Professor, Department of Pharmacology, School of MedicineEmail: dtl10@case.edu
Phone: 216.368.6971
We are interested in utilizing X-ray and electron microscopic technologies to study macromolecular complexes that underlie the activation of G protein-coupled receptors and G proteins. We also utilize Mass spectroscopy and other biophysical techniques to further understand the enzymology and kinetics of these processes.
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Hua Lou, PhD
Associate Professor, Department of Genetics and Genome Sciences, School of MedicineEmail: hua.lou@case.edu
Phone: 216. 368.6419
I am interested in alternative RNA processing and its role in health and disease, including correction of splicing mutations in diseases.
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Antoine Louveau, PhD
Assistant Professor, Cleveland Clinic Lerner College of Medicine, Lerner Research Institute, Cleveland Clinic, School of MedicineEmail: louveaa@ccf.org
Our lab is interested in the role of the brain barriers (meninges, choroid plexus and blood brain barrier) in the context of neurodevelopmental and neurodegenerative diseases. Particularly, we are interested how the immune cells, vascular cells and stromal cells interact with each other to modulate glial and neuronal function. We use a combination of imaging (macroscopic, confocal, in vivo), flow cytometry (regular and spectral), in vivo intervention (surgeries, pharmacological and genetic) and behavior in mouse models of Autism spectrum disorders and Alzheimer's disease. Our approaches aim at developing new and unconventional therapeutic targets for these disorders.
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Joseph M. Luna, PhD
Assistant Professor, Department of Biochemistry, School of MedicineMember, Center for RNA Science and Therapeutics, School of MedicineMember, Cancer Genomics and Epigenomics Program, Case Comprehensive Cancer CenterDirector, Advanced RNA Profiling CoreEmail: joseph.luna@case.edu
Phone: 216.368.1119
Our lab explores topics at the interface between molecular virology and the systems-level host response to RNA virus infections, with a special emphasis on RNA driven processes. Incorporating classic virology approaches with innovative sequencing and imaging methods, our approach emphasizes the investigation of host-pathogen interactions in a diverse array of disease-relevant contexts, from COVID-19 to cancer.
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Peder Lund, PhD
Assistant Professor, Department of Nutrition, School of MedicineMember, Molecular Oncology Program, Case Comprehensive Cancer CenterAssistant Professor, Department of Pharmacology, School of MedicineEmail: peder.lund@case.edu
Our lab is generally interested in how resident microbes in the gut interact with the host epithelium to promote homeostasis and how these interactions become altered in pathological states like inflammatory bowel disease. Specifically, we study how small molecules produced by microbes serve as metabolic precursors and receptor ligands, thereby influencing energy balance and gene expression in host cells.
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Donal S. Luse , PhD
Lerner Research Institute, Cleveland Clinic Lerner College of Medicine of Case Western Reserve UniversityEmail: donal.luse@case.edu
Phone: 216.445.7688
I research Eukaryotic gene transcription and RNA polymerase.
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Chao Ma, PhD
Assistant Staff, Center for Immunotherapy and Precision Immuno-Oncology, Lerner Research Institute, Cleveland ClinicMember, Immune Oncology Program, Case Comprehensive Cancer CenterEmail: mac7@ccf.org
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Jaroslaw P. Maciejewski, MD, PhD
Professor, Department of Medicine, School of MedicineProfessor, Department of Pathology, School of MedicineMember, Cancer Genomics and Epigenomics Program, Case Comprehensive Cancer CenterEmail: maciejj@ccf.org
Phone: 216.445.5962
My areas of investigation include hematology and pathophysiology of hematologic diseases including bone marrow failure syndromes (BMFS).
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Ganapati Mahabaleshwar, PhD
Associate Professor, Department of Pathology, School of MedicineEmail: ghm4@case.edu
Phone: 216.368.5998
I research transcriptional regulation of inflammatory response.
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Danny Manor, PhD
Professor, Department of Nutrition, School of MedicineVice Chair, Department of Nutrition, School of MedicineProfessor, Department of Pharmacology, School of MedicineMember, Molecular Oncology Program, Case Comprehensive Cancer CenterEmail: dxm178@case.edu
Phone: 216.368.6230
I focus on signal transduction pathways that regulate normal cell growth and are disrupted by oncogenic mutations. In addition, I research molecular mechanisms underlying cancer chemo-preventative agents such as vitamin E.