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Sanford Markowitz, MD, PhD
Ingalls Professor of Cancer Genetics, Department of Medicine, School of MedicineProfessor, Department of Genetics and Genome Sciences, School of MedicineProfessor, Department of Molecular Biology and Microbiology, School of MedicinePrincipal Investigator, Case GI SPORE, Case Comprehensive Cancer CenterMember, Cancer Genomics and Epigenomics Program, Case Comprehensive Cancer CenterEmail: sxm10@case.edu
Phone: 216-368-1976
My research is primarily focused on the molecular biology of colon cancer, functional influence of oncogenes and suppressor genes on transformation, metastasis, and response to therapies.
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Divita Mathur
Assistant Professor, ChemistryEmail: dxm700@case.edu
Phone: 216.368.4476
We build synthetic nucleic acid nanoparticles (such as DNA origami) to advance gene therapies and artificial light harvesting systems. Our group utilizes multi step Förster resonance energy transfer and live cell imaging to address challenges in gene delivery.
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Kenneth Matreyek, PhD
Assistant Professor, Department of Pathology, School of MedicineMember, Cleveland Center for Membrane & Structural Biology, School of MedicineEmail: kenneth.matreyek@case.edu
Phone: 216.368.0626
I perform large-scale mutational experiments characterizing the impacts of protein coding variants on cell function, including infectious diseases and immunity.
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Ryota Matsuoka, PhD
Assistant Professor, Department of Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine of Case Western Reserve UniversityEmail: matsuor@ccf.org
Research projects in the Matsuoka Lab aim to decode genetic programs controlling vascularization, vascular cell diversity, and barrier integrity in the central nervous system. We employ advanced genetic, imaging, and omics approaches to dissect these developmental mechanisms using the zebrafish in vivo model combined with human-derived endothelial cell culture in vitro. Our goal is to discover novel molecular targets from our basic science research and translate this knowledge into developing therapeutics that can repair vascular and neural abnormalities in neurological diseases.
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Shigemi Matsuyama, DVM, PhD
Professor, Department of Ophthalmology and Visual Sciences, School of MedicineProfessor, Department of Pathology, School of MedicineProfessor, Department of Pharmacology, School of MedicineProfessor, Hematology and Oncology, Department of MedicineProfessor, Division of General Medical SciencesProfessor, Case Comprehensive Cancer CenterEmail: sxm193@case.edu
Phone: 216.368.5832
,My research includes cell death regulation, mechanism of epigenetic aging, the biological significance of DNA methylation age determining the timing of death, and the development of cell death inhibiting small compounds.
Primary appointment - Ophthalmology
Other appointments - Pharmacology, Pathology, General Medical Science, Case Comprehensive Cancer Center
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Keith R. McCrae, MD
Professor, Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve UniversityMember, Developmental Therapeutics Program, Case Comprehensive Cancer CenterDirector, Classical Hematology, Cleveland Clinic Taussig Cancer InstituteDirector, Physician-Scientist Development, Lerner Research Institute, Cleveland ClinicEmail: mccraek@ccf.org
Phone: 216.445.8185
My focus is in vascular function in health and disease; inflammation and thrombosis, antiphospholipid antibodies, and miRNA.
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Brian McDermott, PhD
Associate Professor, Department of Otolaryngology, School of MedicineAssociate Professor, Department of Genetics and Genome Sciences, School of MedicineEmail: brian.m.mcdermott@case.edu
Phone: 216.844.6036
My research involves neurobiology of the auditory hair cell: mechanotransduction, synaptic transmission, and development. I also research Zebrafish models of deafness.
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Thomas M. McIntyre, PhD
Professor, Department of Molecular Medicine, School of MedicineMember, Molecular Oncology Program, Case Comprehensive Cancer CenterEmail: mcintyt@ccf.org
Phone: 216.444.1048
I investigate lipid signaling molecules that control intracellular functions in human inflammation. I also research enzymes that make and inactivate lipid signaling molecules, and their roles in human disease.
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Timothy J. Mead, PhD
Assistant Professor, Department of Pediatrics, School of MedicineStaff Scientist, Department of Pediatrics, University Hospitals Cleveland Medical CenterAssistant Professor, Department of Genetics and Genome Sciences, School of MedicineEmail: tjm192@case.edu
Phone: 216.368.2350
Our research centers on how changes in the extracellular matrix results in dysfunctional heart development and resulting congenital heart defects. We utilize preclinical mouse models of congenital heart disease, cell culture, genomics, biochemistry, and proteomics to understand the molecular mechanisms underlying these diseases towards the development of therapeutic approaches. Our current major research focus is on the novel concept of inhibiting a protease that remodels fibrillin microfibrils in the aorta to identify a therapeutic for Marfan syndrome.
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Jason A. Mears, PhD
Graduate Program Director, Department of Pharmacology, School of MedicineProfessor, Department of Pharmacology, School of MedicineAssociate Director, Training and Education, Case Comprehensive Cancer CenterMember, Molecular Oncology Program, Case Comprehensive Cancer CenterEmail: jam348@case.edu
Phone: 216.368.3348
My research focuses on structural and functional studies to reveal the impact of mitochondrial dynamics on cell health and proliferation in human diseases, including cancer, neurodegeneration and cardiomyopathy. My areas include cryo-electron microscopy, biochemistry, computational biology, and cancer stem cell models.