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Pushpa Pandiyan, PhD
Associate ProfessorBiological SciencesSchool of Dental MedicineMemberImmune Oncology ProgramCase Comprehensive Cancer CenterMemberCenter for AIDS ResearchEmail: pushpa.pandiyan@cwru.edu
Phone: 216.368.2939
My research includes mucosal immunology, immune dysfunction during infections, T-cell subsets and immunoregulation during inflammation and tumorigenesis.
Nikhil Panicker, PhD
Assistant Professor/StaffDepartment of NeurosciencesLerner Research Institute Cleveland ClinicSchool of MedicineEmail: PANICKN@ccf.org
The Panicker lab investigates the molecular mechanisms that drive pathology in Dementia with Lewy bodies (DLB), Parkinson’s Disease (PD), and Alzheimer’s Disease (AD), with the eventual goal of developing therapeutics that block or slow disease progression. We study cell-death pathways in neurodegenerative diseases, and how neuroinflammation (primarily mediated by microglial cells in the brain) contributes to the pathogenesis of neurologic disorders.
Reshmi Parameswaran, MS, PhD
Assistant ProfessorDepartment of PathologySchool of MedicineAssistant ProfessorDepartment of PediatricsSchool of MedicineAssistant ProfessorDepartment of MedicineSchool of MedicineMemberImmune Oncology ProgramCase Comprehensive Cancer CenterEmail: rxp278@case.edu
Phone: 216.368.5697
I develop new tools for cancer immunotherapy including adoptive Natural Killer (NK) and CAR-T therapies. I also research mechanisms of drug resistance in leukemia and lymphoma, and understand mechanisms of NK cell cytotoxicity to improve NK therapy.
Paul Park, PhD
Associate ProfessorDepartment of Ophthalmology and Visual SciencesSchool of MedicineEmail: paul.park@case.edu
Phone: 216.368.2533
,My research is in structure-function studies of rhodopsin, molecular mechanisms of retinal degeneration, and rhodopsin dysfunction in retinal disease.
Primary appointment - Ophthalmology
Other appointments - Pharmacology, Biochemistry
Brian Perkins, PhD
Associate StaffCleveland Clinic Lerner College of MedicineLerner Research Institute, Cleveland ClinicCleveland Clinic Lerner College of Medicine of Case Western Reserve UniversityPhone: 216.444.9683
Methods to stimulate regeneration of damaged or diseased neurons represents a major therapeutic goal for neurodegenerative diseases. Zebrafish have the capacity to regenerate lost neurons and our goal is to understand how the fish regenerates cells of the retina so that we can perhaps one day mimic the same process in order to restore vision. We will study retinal degeneration in zebrafish carrying mutations that lead to progressive neuronal degeneration and determine the role of microglia and Notch signaling in promoting neuronal regeneration.
Polyxeni (Pola) Philippidou, PhD
Assistant ProfessorDepartment of NeurosciencesSchool of MedicineEmail: pxp282@case.edu
Phone: 216.368.2018
I research molecular mechanisms of neural circuit assembly during development, genetic control of phrenic motor neuron identity; synaptic specificity in respiratory circuits; Hox genes.
Andrew Pieper, MD, PhD
ProfessorDepartment of PsychiatrySchool of MedicineProfessorDepartment of NeurosciencesInvestigatorUniversity Hospitals Harrington Discovery InstituteHarrington Discovery InstituteAssociate DirectorMedical Scientist Training ProgramSchool of MedicineEmail: andrew.pieper@case.edu
Neuropsychiatry with particular focus on neurodegeneration in disease, injury, and aging; translational basic science leading to new therapies for patients.
Irina Pikuleva, PhD
Carl F. Asseff Professor and Vice Chair for ResearchDepartment of Ophthalmology and Visual SciencesSchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterProfessorCardiovascular Research InstituteEmail: irina.pikuleva@case.edu
Phone: 216.368.3823
,Studies of cholesterol maintenance in the retina and brain to delineate the importance of cholesterol-related pathways for retinal and brain functions and whether pharmacologic modulation of these pathways could lead to disease-modifying treatments for retinal and brain disorders.
Primary appointment - Ophthalmology
Secondary appointment - Pharmacology
Theresa Pizarro, PhD
ProfessorDepartment of PathologySchool of MedicineAssociate ProfessorDepartment of MedicineSchool of MedicineEmail: Theresa.Pizarro@case.edu
Phone: 216.368.3306
I focus on basic and translational research in gut mucosal immunity, including IBD and colitis-associated cancer. I also research sex differences and impact of microbiome in IBD and basic cytokine biology, particularly of IL-1 family members.
Xin Qi, PhD
ProfessorDepartment of Physiology and BiophysicsSchool of MedicineEmail: xin.qi2@case.edu
Phone: 216.368.4459
I research altered mitochondrial quality control and metabolic dysregulation in neurodegenerative disease - Huntington's, Parkinson's and Alzheimer's diseases, and develop therapeutics for these diseases.