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Reshmi Parameswaran, MS, PhD
Associate Professor, Department of Medicine, School of MedicineAssociate Professor, Department of Pathology, School of MedicineAssociate Professor, Department of Pediatrics, School of MedicineMember, Immune Oncology Program, Case Comprehensive Cancer CenterEmail: rxp278@case.edu
Phone: 216.368.5697
I develop new tools for cancer immunotherapy including adoptive Natural Killer (NK) and CAR-T therapies. I also research mechanisms of drug resistance in leukemia and lymphoma, and understand mechanisms of NK cell cytotoxicity to improve NK therapy.
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Paul Park, PhD
Associate Professor, Department of Ophthalmology and Visual Sciences, School of MedicineEmail: paul.park@case.edu
Phone: 216.368.2533
,My research is in structure-function studies of rhodopsin, molecular mechanisms of retinal degeneration, and rhodopsin dysfunction in retinal disease.
Primary appointment - Ophthalmology
Other appointments - Pharmacology, Biochemistry
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Brian Perkins, PhD
Associate Staff, Cleveland Clinic Lerner College of Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine of Case Western Reserve UniversityPhone: 216.444.9683
Methods to stimulate regeneration of damaged or diseased neurons represents a major therapeutic goal for neurodegenerative diseases. Zebrafish have the capacity to regenerate lost neurons and our goal is to understand how the fish regenerates cells of the retina so that we can perhaps one day mimic the same process in order to restore vision. We will study retinal degeneration in zebrafish carrying mutations that lead to progressive neuronal degeneration and determine the role of microglia and Notch signaling in promoting neuronal regeneration.
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Polyxeni (Pola) Philippidou, PhD
Associate Professor, Department of Neurosciences, School of MedicineWeidenthal Family Designated Professorship in Career Development, Department of Neurosciences, School of MedicineDirector, Neurosciences PhD Program, School of MedicineEmail: Polyxeni.Philippidou@case.edu
Phone: 216.368.2018
I research molecular mechanisms of neural circuit assembly during development, genetic control of phrenic motor neuron identity; synaptic specificity in respiratory circuits; Hox genes.
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Andrew A. Pieper, MD, PhD
Professor, Department of Psychiatry, School of MedicineProfessor, Department of NeurosciencesProfessor, Department of PathologyInvestigator, University Hospitals Harrington Discovery Institute, Harrington Discovery InstituteAssociate Director, Medical Scientist Training Program, School of MedicineEmail: andrew.pieper@case.edu
Phone: 216.368.4273
Neuropsychiatry with particular focus on neurodegeneration in disease, injury, and aging; translational basic science leading to new therapies for patients.
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Irina Pikuleva, PhD
Carl F. Asseff Professor and Vice Chair for Research, Department of Ophthalmology and Visual Sciences, School of MedicineMember, Developmental Therapeutics Program, Case Comprehensive Cancer CenterProfessor, Cardiovascular Research InstituteDirector, Visual Sciences Research CenterEmail: irina.pikuleva@case.edu
Phone: 216.368.3823
,Studies of cholesterol maintenance in the retina and brain to delineate the importance of cholesterol-related pathways for retinal and brain functions and whether pharmacologic modulation of these pathways could lead to disease-modifying treatments for retinal and brain disorders.
Primary appointment - Ophthalmology
Secondary appointment - Pharmacology
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Theresa Pizarro, PhD
Professor, Department of Pathology, School of MedicineAssociate Professor, Department of Medicine, School of MedicineEmail: Theresa.Pizarro@case.edu
Phone: 216.368.3306
I focus on basic and translational research in gut mucosal immunity, including IBD and colitis-associated cancer. I also research sex differences and impact of microbiome in IBD and basic cytokine biology, particularly of IL-1 family members.
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Xin Qi, PhD
Jeanette M. and Joseph S. Silber Professor of Brain SciencesProfessor, Department of Physiology and Biophysics, School of MedicineEmail: xxq38@case.edu
Phone: 216.368.4459
I research altered mitochondrial quality control and metabolic dysregulation in neurodegenerative disease - Huntington's, Parkinson's and Alzheimer's diseases, and develop therapeutics for these diseases.
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Rajesh Ramachandran, PhD
Associate Professor, Department of Physiology and Biophysics, Case Western Reserve University, School of MedicineEmail: rajesh.ramachandran@case.edu
Phone: 216.368.2513
I research molecular mechanisms of membrane remodeling, fission and fusion in synaptic vesicle endocytosis and mitochondrial dynamics.
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Parameswaran Ramakrishnan, PhD, MS
Associate Professor, Department of Pathology, School of MedicineAssociate Professor, Department of Biochemistry, School of MedicineMember, Immune Oncology Program, Case Comprehensive Cancer Center, School of MedicineResearch Biologist, Louis Stokes Cleveland Veterans Affairs Medical CenterEmail: pxr150@case.edu
Phone: 216.368.2387
I research the regulation of signal transduction in health and disease: autoimmune diabetes, inflammatory diseases and cancer.