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Neena Singh, MD, PhD
Professor, Department of Pathology, School of MedicineProfessor, Department of Neurology, School of MedicineEmail: neena.singh@case.edu
Phone: 216.368.2617
My research includes prion diseases, protein transport, chaperones, proteasomes, and nuclear import.
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Jacek Skowronski, PhD
Professor, Department of Molecular Biology and Microbiology, School of MedicineEmail: jacek.skowronski@case.edu
Phone: 216.368.8930
I research HIV-host cell interaction and accessory proteins.
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Corey Smith , PhD
Professor, Department of Physiology and Biophysics, School of MedicineEmail: corey.smith@case.edu
Phone: 216.368.3487
I research cell physiology, neural circuits and synaptic plasticity, systems neuroscience, neuroendocrinology, autonomic regulation, cardiovascular neuromodulation, and electrophysiology.
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Jonathan D. Smith, PhD
Professor, Department of Molecular Medicine, School of MedicineMember, Molecular Oncology Program, Case Comprehensive Cancer CenterEmail: smithj4@ccf.org
Phone: 216.444.2248
I primarily research cholesterol metabolism by macrophages, the genetics of atherosclerosis susceptibility in mouse models, and genetics and drug discovery in mouse models of Alzheimer disease.
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Apollo Stacy, PhD
Assistant Professor, Department of Molecular Medicine, School of MedicineMember, Molecular Oncology Program, Case Comprehensive Cancer CenterMember, Center for Microbiome and Human Health, Lerner Research InstituteEmail: stacya2@ccf.org
We communicate with our resident microbiota through the language of metabolites. Host-derived metabolites shape the balance between commensals and pathogens, and in turn, microbiota-derived metabolites tune host immune responses. This dialogue ultimately determines our susceptibility to disease. We use bacterial genetics, genomics, animal models, and immune profiling to decipher microbiota-host metabolic communication in the oral cavity, site of one of the most prevalent inflammatory diseases worldwide (periodontitis).
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Jonathan Stamler
President, Harrington Discovery InstituteDirector, Institute for Transformative Molecular Medicine, School of MedicineMy primary research is in redox-based cellular regulation and signal transduction, and in particular the role of protein S-nitrosylation.
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Catherine M. Stein, PhD
Professor, Department of Population and Quantitative Health Sciences, School of MedicineEmail: catherine.stein@case.edu
Phone: 216.368.5631
Dr. Catherine M. Stein’s primary research focus is on genetic and environmental susceptibility to tuberculosis (TB), specifically the genomics of resistance and how genetic variation in both humans and the tuberculosis pathogen influence TB severity. Dr. Stein also works on speech-sound disorder, building upon more than two decades of Case Western Reserve University study.
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Julian E. Stelzer, PhD
Professor, Department of Physiology and Biophysics, School of MedicineEmail: julian.stelzer@case.edu
Phone: 216.368.8636
Our lab studies molecular and in vivo mechanisms of cardiac regulation. We focus on the role of contractile proteins in modulation of mechanical and hemodynamic function in genetic and aquired heart failure. We use biophysical techniques, in vivo cardiovascular phenotyping, and gene replacement approaches to develop novel therapies that improve contractile function in heart failure.
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Ruben Stepanyan
Assistant Professor, School of MedicineOur lab focuses on the physiology of mechanosensory cells of the inner ear; receptors for senses of hearing and balance; in mouse and zebrafish models; electrophysiology, optical and electron microscopy imaging.
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Phoebe L. Stewart, PhD
Vice Chair of Educational Programs, Department of Pharmacology, School of MedicineProfessor, Department of Pharmacology, Case Western Reserve University, School of MedicineMember, Cleveland Center for Membrane and Structural BiologyMember, Developmental Therapeutics Program, Case Comprehensive Cancer CenterEmail: pls47@case.edu
Phone: 216.368.4349
Our lab studies the structure of engineered adenovirus vectors and their complexes with immune molecules. More specifically we focus on understanding the molecular mechanisms underlying systemic inflammation and how targeted viral capsid mutations might alter host-pathogen interactions. We utilize cryo-electron microscopy (cryo-EM) single particle reconstruction and tomography, molecular dynamics and molecular modeling.