For the past 50 years I worked on the metabolic regulation of organs and cells in health and disease, using biochemical, isotopic and metabolomic techniques.
one-one one mentoring in metabolic (dys)regulation
- Fall 2010: Metabolic regulation of perfused organs
- Faculty in Annual NIDDK-sponsored course in "Use of isotopic techniques for metabolic research" (for 13 years)
Dr. Brunengraber's research concentrates on metabolic regulation investigated in isolated cells and perfused organs by a combination of metabolomics and stable isotopic technologies based on mass spectrometry. This combination allows the discovery of new metabolic pathways and new regulatory mechanisms. It was with these techniques that, in 1994, his lab discovered what is now called the reductive metabolism of glutamine. This process plays an important role in the metabolism of cancer cells.
- Metabolic regulation of pancreatic cancer
- Pathobiochemistry of retinopathy of prematurity
- Pathobiochemistry of macular degeneration
- Preservation of perfused limbs in preparation to transplantation
- Nephropathy of diabetes
- Co-Investigator in 2 NIH grants (5 and 4 years, starting 07/2021) to Dr Bela Anand-Apte, Dept of Ophthalmology, Lerner Research Institute, Cleveland Clinic
- Co-investigator in new NIH grant (5 years starting 07/2021) to Dr Jeffrey Schelling Dept Medicine CWRU