Proteomics

Services

The overall goal of the Proteomics Shared Resource (SR) is to make advanced mass spectrometry instruments, expertise, and methods for proteome analysis available to all investigators.

Services include the following:

• Protein Identification
• Characterization of post-translational modifications
• Quantitation of protein expression
  • Quantitative Top-Down Proteomics using 2-D gels
  • Quantitative Bottom-Up Proteomics using LC-MS
  • Experimental Design for Quantitative Proteomics
  • Data analysis
• Untargeted and targeted metabolomic quantification
• Bioinformatics analysis
• Training
• Independent use
• Interactome analysis
• Structural analysis (protein footprinting)

Resources

Case Western Reserve University facility

• Thermo Scientific 480 Exploris Orbitrap mass spectrometer with Vanquish UPLC
• Thermo Scientific Eclipse Tribrid mass spectrometer with Vanquish UPLC
• Thermo Scientific Q Exactive Plus mass spectrometer with Waters Acquity HPLC
• Thermo Scientific TSQ Altis with HP1100 HPLC

Lerner Research Institute facility

• ThermoFinnigan LTQ

• ThermoFinnigan LTQ-Orbitrap Elite

More Information

Case Western Reserve University
Center for Proteomics and Bioinformatics
https://case.edu/medicine/nutrition/case-center-proteomics-and-bioinformatics

Cleveland Clinic Lerner Research Institute
Proteomics & Metabolomics Core
lerner.ccf.org/cores/proteomics-metabolomics/

Acknowledgment

Remember to acknowledge the valuable services provided by Cancer Center Shared Resources in your research papers and publications: 
"This research was supported by the Proteomics Shared Resource of the Case Comprehensive Cancer Center (P30CA043703)."

Contact for More Information