We help you navigate the complexity so you can focus on the science.
Turning promising discoveries into new cancer treatments requires more than great science. It requires the expertise, infrastructure, and regulatory support to move studies from concept to activation and successfully conduct them across multiple institutions.
Case CCC’s Clinical Research Office (CRO) helps investigators navigate every stage of the clinical research process—from study development and protocol design to trial activation, participant enrollment, data management, and reporting. By providing centralized support and oversight, the CRO helps researchers launch and manage clinical trials efficiently while maintaining the highest standards of scientific quality, participant safety, and regulatory compliance.
Support Throughout the Clinical Trial Lifecycle
Whether you are developing an investigator-initiated trial, conducting a multi-site study, or collaborating with industry sponsors, the CRO provides expert guidance and operational support throughout the research process.
Services include:
- Study concept development and protocol design
- Feasibility assessment and trial planning
- Budget development and contract support
- Research nursing and clinical trial coordination
- Regulatory management, including IND support
- Data management and reporting
- Sponsor and collaborator engagement
- Quality assurance and staff education
Our goal is to help investigators move innovative studies forward while reducing administrative burden and supporting successful trial execution.
Scientific Review That Strengthens Research
The Protocol Review and Monitoring Committee (PRMC) helps ensure that cancer clinical trials are scientifically rigorous, feasible, and aligned with the Case CCC’s research priorities.
Beyond fulfilling NCI requirements, the review process provides investigators with valuable scientific feedback that can strengthen study design, improve feasibility, and support successful trial implementation. Ongoing monitoring helps ensure studies continue to make meaningful scientific progress and achieve enrollment goals.
Tools That Improve Efficiency and Transparency
The OnCore® Clinical Trials Management System provides investigators and study teams with a centralized platform for managing cancer clinical trials across the consortium.
This secure system supports study tracking, reporting, compliance, financial management, and operational oversight, helping research teams maintain visibility into trial progress and meet regulatory requirements throughout the life of a study.
Protecting Participants and Ensuring Data Integrity
The Data Safety and Toxicity Committee (DSTC) provides centralized oversight of participant safety and study conduct for investigator-initiated trials.
Working in conjunction with the Case CCC Data and Safety Monitoring Plan (DSMP), the DSTC helps ensure that studies are conducted responsibly, data remain reliable, and participants are protected throughout the research process—supporting the integrity of the science and the trust placed in clinical research. Data Safety and Monitoring Plan (DSMP).