The Case Comprehensive Cancer Center (Case CCC), the exceptional powerhouse consortium of Case Western Reserve University, University Hospitals and Cleveland Clinic, represents all cancer research in Northeast Ohio.

High Impact Discoveries

Our scientists pursue discoveries that lead to innovative prevention strategies, early detection, therapeutic development and new clinical trials. We are using artificial intelligence (AI) to inform decisions, improve prognostic accuracy and understand the genomics of cancer. Our cell therapy research continues decades-long “first in human” innovation using novel products for cancer treatment and prevention of infection. We are discovering new cancer pathways and developing targeted therapies to block these paths and prevent cancer progression. We are developing new drugs for cancer patients.

Focus on Issues Facing our Community

We seek to understand and address the challenges facing the communities we serve. We practice and study ways to rebuild trust, facilitate access and increase understanding to improve health across our communities. Communities across the country face parallel challenges, and the solutions we implement at a local level will translate into national impact and benefit.

Cleveland-wide Research Expertise 

Our membership includes nearly 400 cancer investigators, spanning 68 departments of the Schools of Medicine, Nursing, Dentistry, Engineering, Applied Social Sciences, and the College of Arts and Sciences, located at Case Western Reserve University, University Hospitals, Cleveland Clinic and MetroHealth Medical Center. The research efforts of members are organized into seven interdisciplinary scientific programs and supported by 13 specialized shared resources.

Coordinated Clinical Research

Our Center is a leader in the development of cancer clinical trials, especially early phase trials. Our clinical research effort is supported by 12 Clinical Trials Disease Teams that develop and prioritize clinical trials, and a single Protocol Review and Monitoring System, Data Safety and Monitoring Plan to integrate cancer research, cancer therapeutics, and prevention services at the partner institutions and throughout the region. Through this system processes are streamlined, making it possible to get new treatments to patients, faster.

Collaborative Team Science

Complex research problems often require a team science approach, relying on strong leaders to drive collaboration. At our Center, experts with complementary strengths join together to lead large-scale multi-investigator grants including the GI Specialized Program of Research Excellence (SPORE)Cancer Disparities Specialized Program of Research Excellence (SPORE) Planning GrantBarrett's Esophagus Translational Research Network (BETRNet), Ohio Brain Tumor Working Group.