Chao-Pin Hsiao | Case Comprehensive Cancer Center

Associate Professor

Frances Payne Bolton School of Nursing

Member

Population and Cancer Prevention Program

Case Comprehensive Cancer Center

Teaching Information

Teaching Interests

Translational Research
Symptom Management
Oncology Nursing

Research Information

Research Interests

Cancer patient symptom management
Molecular-genetic mechanisms of cancer-related fatigue
Mitochondrial bioenergetic mechanisms of radiation-induced fatigue

Research Projects

Current

Unraveling the Associations of Molecular-Genetic Bioenergetics and Chemotherapy Induced Fatigue Symptoms in Patients with Breast Cancer” (PI: Chao-Pin Hsiao)
Funding Agency: NIH, National Institute of Nursing Research (R21)
Period: 08/2022 - 08/2024

This study investigates the molecular-genetic pathway of mitochondrial bioenergetics and their association with chemotherapy (CT)-induced cancer-related fatigue (CRF) symptoms experienced by patients with breast cancer receiving CT-containing anthracyclines, compared to those with non-anthracycline-based CT.

Completed

Cancer-related Fatigue: Determine the Mitochondrial Bioenergetic Profile of Persistent Radiation-Induced Fatigue” (PI: Chao-Pin Hsiao)
Funding Agency: VPR Catalyst Award/ Seed Funding, CWRU
Period: 06/2018-06/2019

This study investigates mitochondrial bioenergetics mechanisms of radiation-induced persistent fatigue by determining associations between changes in mitochondrial gene expression, bioenergetics, and fatigue in prostate cancer patients 24-months after completion of radiotherapy.

Mitochondrial Bioenergetic Mechanism of Cancer Related Fatigue
(PI: Chao-Pin Hsiao)
Funding Agency: NIH, National Institute of Nursing Research (K01)
Period: 08/2015-06/2018

This study examines the association among certain genes, mitochondrial bioenergetics, and fatigue in prostate cancer patients receiving localized radiation therapy over a period of time and to compare differences in gene expression, the mitochondrial bioenergetics profile, and fatigue between the patients with radiation therapy and on active surveillance.

Mitochondrial Gene Expression, Mitochondrial Bioenergetics, and Fatigue in Patients with Prostate Cancer (PI: Chao-Pin Hsiao)
Funding Agency: CTSC Core Utilization Pilot Grant, Case Western Reserve University
Period: 04/2017-09/2017

This grant supports a subset analysis of mitochondrial-related gene expression providing strong evidence regarding a hypothesized genomic-molecular mechanism of cancer-related fatigue and mitochondrial bioenergetics, as well as determining biomarkers of mitochondrial bioenergetics for cancer fatigue.

Changes in Mitochondrial Bioenergetics and Cancer-Related Fatigue in Prostate Cancer
(PI: Chao-Pin Hsiao)
Funding Agency: Oncology Nursing Society Foundation (RE01)
Period: 01/2014-01/2016

This is a pilot study exploring mitochondrial functions and fatigue experience in patients receiving localized radiation therapy. It focuses on establishing laboratory procedures and baseline data.

Relationship between Mitochondrial Dysfunction and Fatigue in Cancer Patients Following External Beam Radiation Therapy (PI: Chao-Pin Hsiao)
Funding Agency: NIH, National Institute of Nursing Research, Intramural Research Program
Period: 05/2009-01/2014

This study explored changes in the expression of mitochondrial genes that are associated with fatigue symptoms of prostate cancer patients receiving localized radiation therapy.

Investigating Molecular-Genetic Correlates of Fatigue in Cancer Patients Receiving Localized External Beam Radiation Therapy (Role: Lead Associate Investigator; PI: L. Saligan)
Funding Agency: NIH, National Institute of Nursing Research, Intramural Research Program
Period: 05/2010-01/2014

This study explored explores the molecular-genetic mechanisms underlying fatigue and the cluster of symptoms (urinary, sexual, gastrointestinal, and psychiatric) experienced by prostate cancer patients undergoing External Beam Radiation Therapy (EBRT).

Investigating Correlates of Fatigue in Cancer Patients Receiving Treatment (Role: Lead Associate Investigator; PI: L. Saligan)
Funding Agency: NIH, National Institute of Nursing Research, Intramural Research

Period: 06/2011-01/2014

Program. This study explored explores the molecular-genetic mechanisms underlying fatigue experienced by cancer patients receiving various therapies (e.g., immune and chemotherapy).

Awards and Honors

The Junior Research Researcher Award

Midwest Nursing Research Society

Professional Memberships

Member, Midwest Nursing Research Society (MNRS), 2013-present

Member, Oncology Nursing Society, 2003 – present

Member, Sigma Theta Tau, Beta Mu Chapter 2003 – present

Member, International Sigma Theta Tau, 1999 – present

Publications

Hsiao, C.P., Daly, B., Chen, M. K., Veigl, M., Dorth, J., Ponsky, L. E., & Hoppel, C. (2021). Possible Bioenergetic Biomarker for Chronic Cancer-Related Fatigue. Nurs Res, 70(6), 475-480. https://doi.org/10.1097/nnr.0000000000000547
Hsiao, C.P., Dickinson K, Gonzalez-Marrero V, Kelly DL, Lukkahatai N, McCabe M, Mayo, S, Musanti R, & Saligan LN (2019). Consortium Building for Nurse Scientists Interested in Symptom Research in the Era of Precision Health. The Journal of Nursing Scholarship. 52(2):183-191.
Hsiao, C.P., Chen, MK., Veigl, M., Ellis, R., Cooney, M., Daly, B., & Hoppel, C. (2019). Relationships between expression of BCS1L, mitochondrial bioenergetics, and among patients with prostate cancer. Cancer Management and Research. 11, 6703-6717
Hsiao, C.P., Chen, MK., Daly, B., & Hoppel, C. (2018). Integrated Mitochondrial Function and Cancer-related Fatigue in Men with Prostate Cancer Undergoing Radiation Therapy. Cancer Management and Research. 10, 6367-6377
Hsiao, C.P. & Hoppel, C. (2018). Analyzing Mitochondrial Function in Human Lymphocytes. Analytical Biochemistry:Methods in the Biological Science, 549, 12-20. †
Hsiao C.P., Chen M-K, Meyers KJ, Saligan LN (2017). Symptoms predicting health-related quality of life in prostate cancer patients treated with localized radiation therapy. Family Medicine and Community Health. 5(2):119-128.
Hsiao, C.P., Daly, B., & Saligan, L. (2016). The Etiology and management of radiotherapy-induced fatigue. Expert Review of Quality of Life in Cancer Care, 1(4), 323-328
Kelly DL, Dickinson K, Hsiao C-P, Lukkahatai N, Gonzalez-Marrero V, McCabe M, Saligan LN (2016). Biological Basis for the Clustering of Symptoms, Seminars in Oncology Nursing, doi:10.1016/j.soncn.2016.08.002
Hsiao, C.P., Daly, B., & Hoppel, C. (2015). Association between Mitochondrial Bioenergetics and Radiation-related Fatigue: A Possible Mechanism and Novel Target. The Journal of Archives in Cancer Research, 3 (2), 1-9
Hsiao, C.P., Araneta, M., Reddy, S.Y., Chen, M.-K., & Saligan, L. (2015). Genomic Profile of Fatigued Men While receiving Localized Radiation Therapy. The Journal of Biological Research for Nursing. 2016 May;18(3):281-9. doi: 10.1177/1099800415618786. Epub 2015 Nov 29.
Feng, R., Chen, M.-K., Lukkahatai N, Hsiao, C.P., Kaushal, A., Lee Sechrest & Saligan, L. (2015). Clinical predictors of fatigue in non-metastatic prostate cancer patients receiving external beam radiation therapy. Journal of Clinical Oncology Nursing, 19 (6), 744-750
Hsiao, C.P., Wang, D., Kaushal, A., Chen, M.-K., & Saligan, L. (2014). Differential Expression of Genes Related to Mitochondrial Biogenesis and Bioenergetics in Fatigued Prostate Cancer Men Receiving External Beam Radiation Therapy. Journal of Pain and Symptom Management, 48 (6), 1080-90.
Lukkahatai N, Patel S, Gucek M, Hsiao C.P., Saligan LN. (2014). Proteomic Serum Profile of Fatigued Men Receiving Localized External Beam Radiation Therapy for Non-Metastatic Prostate Cancer. J Pain Symptom Manage, 47 (4), 748-56.
Hsiao, C. P., Moore, I. M. (Ki), Insel, K.C. & Merkle, C. (2014). Symptom Self-Management Strategies in Localized Prostate Cancer. Journal of Clinical Nursing, 23 (3-4), 440-9.
Hsiao, C.P., Araneta, M., Wang, X-M., Saligan, L. (2013). The association of IFI27 Expression and Fatigue Intensification during Localized Radiation Therapy: Implication of a Para-Inflammatory Bystander Response. International Journal of Molecular Science, 14 (8), 19643-57.
Hsiao, C.P., Wang, D., Kaushal, A., Saligan, L. (2013). Mitochondria-related gene expression changes are associated with fatigue in patients with nonmetastatic prostate cancer receiving external beam radiation therapy. Cancer Nursing, 36 (3), 189-97.
Saligan LN, Hsiao C.P., Wang D, Wang X, Kaushal A, Citrin D, Barb JJ, Munson PJ, Dionne RA. (2012). Upregulation of α-synuclein during localized radiation therapy signals the association of cancer-related fatigue with the activation of inflammatory and neuroprotective pathways. Brain, Behavior, and Immunity, 27 (1), 63-70.
Insel, K.C., Merkle, C. J., Hsiao, C.P., Vidrine, A.N., & Montgomery, D.W. (2012). Biomarkers for Cognitive Aging--Part I: Telomere Length, Blood Pressure and Cognition Among Individuals With Hypertension. Biological Research for Nursing, 14 (2), 124-32.
Hsiao, C. P., Moore, I. M. (Ki), Insel, K.C. & Merkle, C. (2011). High perceived stress is linked to afternoon cortisol levels and greater symptom distress in patients with Localized Prostate Cancer. Cancer Nursing, 34 (6), 470-78.

Education

Doctor of Philosophy

Injury Mechanisms and Biobehavior

University of Arizona, School of Nursing

Master of Science in Nursing

Oncology

National Taiwan University, School of Nursing

Bachelor of Science in Nursing