Jack Khouri, MD

Assistant Professor
Department of Medicine
Cleveland Clinic Lerner College of Medicine of Case Western Reserve University
Immune Oncology Program
Case Comprehensive Cancer Center

Dr. Jack Khouri is Associate Staff in Hematology and Medical Oncology at Cleveland Clinic Taussig Cancer Center and Assistant Professor at Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. He is a clinician in the myeloma program, blood and marrow transplant program and section of apheresis medicine. In his current role, Dr. Khouri cares for patients with PCDs in the outpatient setting and attend to the lymphoma/myeloma and bone marrow transplant inpatient services. He also oversees various procedures in the cancer center’s apheresis unit ranging from leukapheresis for mononuclear cell collections for HCT and CAR T cell therapy to inpatient and outpatient plasma exchange and photopheresis procedures for a variety of medical conditions across multiple medical specialties.

Dr. Khori is passionate about clinical research, clinical trials and medical education. He dedicates most of his research time to designing clinical trials and collaborating with pharmaceutical companies on real world observational studies and trialsin PCDs and HCT. His lab  recently published the results of a phase 1b study of azacytidine/ lenalidomide/ dexamethasone in relapsed/refractory myeloma and presented the results of a phase 2 study of an investigational IgG1 monoclonal antibody (CAEL-101) that targets the misfolded light chains of AL amyloid fibrils in combination with CyBorD in AL amyloidosis at the 2020 ASH meeting.

He also has an interest in the role of apheresis procedures in myeloma and PCDs and is currently working on designing a phase 2 study of plasma exchange in cast nephropathy. Dr. Khouri has a special interest in POEMS syndrome and have created several PCD clinical pathways for our myeloma program namely for POEMS syndrome, MGUS, MGRS and smoldering myeloma.

Dr. Khouri has also been involved with teaching residents and fellows as well as mentoring. He received excellence in teaching awards from Tufts University School of Medicine, Cleveland Clinic Internal Medicine Residency Program and teacher of the year award in hematology from the fellowship program at Cleveland Clinic. He has mentored internal medicine residents including one who received an honorable mention in the medicine grand rounds competition 2020 at Cleveland Clinic and another one who was awarded the ASH 2019 abstract achievement award.


Additional Information