My areas of investigation include regulation of the length of telomere repeats and their role in cell physiology, genetic pathways controlling gene silencing and cell aging, and the biology and biochemistry of vitamin K in mammals.
Research Information
Research Projects
The goal of our laboratory is to understand what roles telomeres play in chromosome stability and segregation and how this information is communicated to the cell cycle machinery. We approach these problems by studying the regulation of yeast telomere length and the proteins that are part of yeast telomeric chromatin using yeast genetics and molecular biological and biochemical approaches. These studies on telomere proteins have led us into a separate project investigating how these proteins regulate yeast life span.