Liangliang (Lyons) Zhang, PhD

Assistant Professor
Department of Population and Quantitative Health Sciences
School of Medicine
Immune Oncology Program
Case Comprehensive Cancer Center

Dr. Zhang's research interests center around Bayesian inference and prediction, high dimensional models, and complex structured data, such as brain imaging and metagenomic data.

He works closely with biostatisticians and clinicians on linking quantitative microbiome profiling from different body sites (gut, oral, tumor, urine, etc.) to cancer-related disease outcomes and investigating how the microbiota can influence the outcome of cancer immunotherapy.

He has broad computational expertise in analyzing and modeling across data types and studies and focuses on developing quantitative methods and bioinformatic tools to identify biomarkers that can be used in specific immunotherapy or treatment design. He has developed Bayesian zero-constrained regression modeling with structured priors for microbiome feature selection. That work was featured in a study recently published in Biometrics. He also has developed progressive permutation for multiple testing problems. That work was recently published in BMC Bioinformatics.

Dr. Zhang has extensive experience in collaborating with medical researchers from different biomedical fields, resulting in publications and abstracts accepted to journals such as Cell, Science, Cancer, and Scientific Reports, among others.

He supports and collaborates in study planning and develops data-driven, intelligent and user-friendly bioinformatics that identify important signals essential in generating quantitative insights.

Follow Dr. Zhang on Twitter @lyonszhang


Professional Memberships

American Statistical Association (ASA)
International Biometric Society, Eastern North American Region
International Society for Bayesian Analysis
International Chinese Statistical Association


Michigan State University
Master of Science
Michigan State University
Master of Science
Applied Mathematics
Soochow University
Bachelor of Science
Nanjing University of Posts and Telecoms

Residencies, Internships and Fellowships

Postdoctoral Scholar
University of Texas MD Anderson Cancer Center