Dr. Tian Liu completed his PhD at Seoul National University in South Korea in 2014. He completed his post-doctoral training and became Assistant Professor at USF Health Byrd Alzheimer’s Institute in 2018. Dr. Liu joined the Department of Pathology at Case Western Reserve University School of Medicine in 2021 as an Assistant Professor. His research focuses on the mitochondria-associated proteins in neurodegenerative diseases, including Alzheimer’s disease (AD), Frontotemporal dementia (FTD), Amyotrophic lateral sclerosis (ALS).
Dr. Liu’s current research focuses on 1) how mitochondria-associated proteins (i.e. CHCHD10) are involved in mitophagy and protein aggregation in Alzheimer’s disease, Frontotemporal dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS); 2) how the alterations of communications between mitochondria and other cellular organelles impact AD pathogenesis; 3) investigating the role of SSH1 and cofilin, A -induced neurotoxicity and tau/microtubule dynamics; and developing SSH1 inhibitors. Dr. Liu’s is also developing the therapeutic approach by utilizing antagoNATs to upregulate endogenous CHCHD10 level in brains of AD models of mice and human neurons.